Risk factors, management, and clinical outcomes of invasive Mycoplasma and Ureaplasma infections after lung transplantation

Tam, Patrick C.K.; Hardie, Rochelle; Alexander, Barbara D.; Yarrington, Michael E.; Lee, Mark J.; Polage, Chris R.; Messina, Julia A.; Maziarz, Eileen K.; Saullo, Jennifer L.; Miller, Rachel; Wolfe, Cameron R.; Arif, Sana; Reynolds, John M.; Haney, John C.; Perfect, John R.; Baker, Arthur W.

doi:10.1016/j.ajt.2023.08.019

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…With the growing number of patients experiencing various types of immunodeficiencies, there is an increasing number of reports regarding the isolation of Mycoplasmas from organs that differ from their usual habitats ( Glanville, 2021 ; Farfour et al., 2024 ). In recent years, Mycoplasmas have been increasingly documented as the causative agents of post-surgical infections in solid organ transplantation, especially in thoracic surgery, including lung and heart transplantation ( Farfour et al., 2024 ; Tam et al., 2024 ). In these cases, the overall mortality rate is notably high, which may, in part, be attributed to delays in diagnosing the underlying cause ( Farfour et al., 2024 ).…”

Section: Discussionmentioning

confidence: 99%

The complete genome sequence of unculturable Mycoplasma faucium obtained through clinical metagenomic next-generation sequencing

Sabat,

Durfee,

Baldwin

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionDiagnosing Mycoplasma faucium poses challenges, and it's unclear if its rare isolation is due to infrequent occurrence or its fastidious nutritional requirements.MethodsThis study analyzes the complete genome sequence of M. faucium, obtained directly from the pus of a sternum infection in a lung transplant patient using metagenomic sequencing.ResultsGenome analysis revealed limited therapeutic options for the M. faucium infection, primarily susceptibility to tetracyclines. Three classes of mobile genetic elements were identified: two new insertion sequences, a new prophage (phiUMCG-1), and a species-specific variant of a mycoplasma integrative and conjugative element (MICE). Additionally, a Type I Restriction-Modification system was identified, featuring 5’-terminally truncated hsdS pseudogenes with overlapping repeats, indicating the potential for forming alternative hsdS variants through recombination.ConclusionThis study represents the first-ever acquisition of a complete circularized bacterial genome directly from a patient sample obtained from invasive infection of a primary sterile site using culture-independent, PCR-free clinical metagenomics.

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Section: Discussionmentioning

confidence: 99%

The complete genome sequence of unculturable Mycoplasma faucium obtained through clinical metagenomic next-generation sequencing

Sabat,

Durfee,

Baldwin

et al. 2024

Front. Cell. Infect. Microbiol.

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Mycoplasma hominis as Cause of Extragenital Infection in Patients with Hypogammaglobulinemia: Report of 2 Cases and Literature Review

Russo,

Mikulska,

Delfino

et al. 2024

Infect Dis Ther

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Mycoplasma hominis can be a part of human urogenital tract microbiome, and it is a frequent cause of urogenital infections. In rare cases, it can also cause extragenital infections, especially in immunocompromised patients. In this case series, we report two cases and provide a literature review of extragenital infections caused by M. hominis in patients with hypogammaglobulinemia. Patient 1 was a 61-year-old woman with diffuse large B-cell lymphoma who, after rituximab-containing chemotherapy and CAR-T therapy, developed M. hominis spondylodiscitis. Patient 2 was a 50-year-old woman with congenital hypogammaglobulinemia who developed disseminated M. hominis infection involving pleura, muscles, and right ankle. Antibiotic therapy with levofloxacin and doxycycline for 10 weeks in patient 1 and with levofloxacin alone for 6 weeks in patient 2 led to infection resolution. The literature review identified 14 additional cases reporting M. hominis extragenital infection in patients with hypogammaglobulinemia. M. hominis should also be suspected as an etiological agent of extragenital infection in patients with B-cell immunodeficiency with a clinical picture of persistent, standard-culture negative infection, particularly with arthritis or abscess formation. Even if M. hominis can grow on standard bacterial medium, in suspected cases molecular methods should be promptly used for correct diagnostic work-up and successful therapy.

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Prevention of Mollicute transmitted infections from donor lungs after lung transplant

Kurihara,

Kaiho,

Bharat

2024

American Journal of Transplantation

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Risk factors, management, and clinical outcomes of invasive Mycoplasma and Ureaplasma infections after lung transplantation

Cited by 6 publications

References 30 publications

The complete genome sequence of unculturable Mycoplasma faucium obtained through clinical metagenomic next-generation sequencing

The complete genome sequence of unculturable Mycoplasma faucium obtained through clinical metagenomic next-generation sequencing

Mycoplasma hominis as Cause of Extragenital Infection in Patients with Hypogammaglobulinemia: Report of 2 Cases and Literature Review

Prevention of Mollicute transmitted infections from donor lungs after lung transplant

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