Risk Factors of Anterior Circulation Intracranial Aneurysm Rupture: Extracranial Carotid Artery Tortuosity and Aneurysm Morphologic Parameters

Pei, Yusong; Xu, Zhihua; Liang, Guobiao; Jin, Hai; Yang, Dan; Yang, Benqiang; Qiao, Xinxin; You, Hongrui; Xing, Dengxiang

doi:10.3389/fneur.2021.693549

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…Clinical data showed that approximately 20% of IA patients had multiple IAs, and 95% of IA patients had IA recurrence or de novo formation after neck clipping in 20 years [7,11]. Kim, Labeyrie and Pei et al found that IA patients were commonly accompanied by tortuous arteries [12,13]. Our previous study also found that patients with IAs showed greater brain artery shifting with the age increasing [14].…”

Section: Introductionsupporting

confidence: 51%

Molecular characteristics of arteries in patients with intracranial aneurysm: integration of WES and RNA-seq

Chen

Zeng

Yan

et al. 2022

Preprint

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Genetic and vascular morphology research suggested intracranial aneurysm (IA) may not be a local artery disease. IA initiation may be correlated with the histological and molecular changes of arteries. We used whole-exome sequencing (WES) of blood and RNA sequencing (RNA-seq) of superficial temporal artery (STA) to explore the artery molecular characteristics of IA under the genetic background, and try to find the potential mechanism of the IA initiation. Fifty IA patients’ and 40 controls’ blood samples were enrolled in WES; 10 IA patients’ and 5 controls’ STA were included in RNA-seq. Bioinformatic analysis was performed. RT-qPCR was used for validation. We analyze the cell types of STA by the xCell algorithm, and conducted a correlation analysis between the endothelium and mutation genes. We identified 2118 genes via RNA-seq, and via WES 43 genes harboring 54 potential deleterious variants. Four genes (ALDH1L2, KCNJ12, SPNS2, TUBB8) had both variants and differential expressions. Xcell algorithms showed that the expression of mutation genes KCNJ12 and SPSN2 were strongly associated with decreasing endothelial cells on STA and higher IA risks. KCN12 and SPSN2 expressions have been validated by RT-qPCR. In total, we have described the artery molecular characteristics of IAs by RNA-seq and WES. A total of two gene mutations (KCNJ12 and SPSN2) were found potentially to facilitate IA initiation by decreasing EC expression in brain arteries.

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Section: Introductionsupporting

confidence: 51%

Molecular characteristics of arteries in patients with intracranial aneurysm: integration of WES and RNA-seq

Chen

Zeng

Yan

et al. 2022

Preprint

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show abstract

“…Early studies have identified relationships between vascular tortuosity and aneurysms [ 19 ], including thoracic aneurysms [ 20 ], coronary aneurysms [ 21 ], and splenic artery aneurysms [ 22 ]. Intracranial aneurysms can be affected by the tortuosity of extracranial or intracranial vessels [ 23 , 24 ]. Vascular tortuosity is usually evaluated by the tortuosity-related length, triangular index, angle metric sum, angle distance product, and other parameters [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tortuosity reportedly increases the risk of aneurysm rupture [ 17 , 23 ]. The relationship between bending and rupture may be influenced by various factors, such as the inflow angle.…”

Section: Discussionmentioning

confidence: 99%

Effect of Siphon Morphology on the Risk of C7 Segment Aneurysm Formation

Wang,

Chen,

Song

et al. 2024

Clin Neuroradiol

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Purpose Tortuosity of the internal carotid artery (ICA) is associated with intracranial aneurysms (IAs). The siphon is the most curved segment of the ICA, but its morphology has controversial effects on IAs. This study aimed to explore the morphometric features of the siphon and the potential hemodynamic mechanisms that may affect C7 aneurysm formation. Methods In this study 32 patients with C7 aneurysms diagnosed at Xiangya Hospital between 2019 and 2021 and 32 control subjects were enrolled after propensity score matching. Computed tomography angiography (CTA) images were acquired to measure morphologic features, and then, by combining clinical data, simplified carotid siphon models were constructed, and computational fluid dynamics (CFD) analysis was performed. Results The presence of C7 aneurysms was associated with the height of the C4–C6 curved arteries (odds ratio [OR] 0.028, 95% confidence interval [CI] 0.003–0.201; P < 0.001). The heights of the C4–C6 curved arteries in the aneurysm group were significantly shorter than those in the control group. The CFD analysis revealed that shorter C4–C6 bends led to greater blood velocity and pressure in the C7 segment arteries. Conclusion A shorter C4–C6 bend was associated with distal C7 aneurysm formation, and an elaborate hemodynamic mechanism may underlie this association.

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Analysis of independent risk factors for aneurysm rupture based on carotid tortuosity index and morphological parameters of single intracranial aneurysms in anterior circulation

Pei,

Wang,

Hao

et al. 2023

Clinical Neurology and Neurosurgery

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Risk Factors of Anterior Circulation Intracranial Aneurysm Rupture: Extracranial Carotid Artery Tortuosity and Aneurysm Morphologic Parameters

Cited by 6 publications

References 27 publications

Molecular characteristics of arteries in patients with intracranial aneurysm: integration of WES and RNA-seq

Molecular characteristics of arteries in patients with intracranial aneurysm: integration of WES and RNA-seq

Effect of Siphon Morphology on the Risk of C7 Segment Aneurysm Formation

Analysis of independent risk factors for aneurysm rupture based on carotid tortuosity index and morphological parameters of single intracranial aneurysms in anterior circulation

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