Risk factors of cardiovascular and cerebrovascular diseases in young and middle-aged adults: A meta-analysis

Wu, Yinghua; Xiong, Yan; Wang, Ping; Li, Rui; Jia, Xin; Kong, Yaguang; Li, Fangfang; Chen, Chen; Zhang, Xia; Zheng, Yuanjin

doi:10.1097/md.0000000000032082

Cited by 11 publications

(8 citation statements)

References 42 publications

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“…Subgroup analysis indicated a strong inverse correlation between egg consumption and incident CED among participants who have been married and not currently smoking. Smoking is a significant risk factor for CED [33]. Findings from the Australian prospective study of cardiovascular risk showed that of 36 subtypes of CVD, 29 event rates were significantly increased in current smokers.…”

Section: Discussionmentioning

confidence: 99%

The Prospective Associations of Egg Consumption with the Risk of Total Cerebrovascular Disease Morbidity among Chinese Adults

et al. 2023

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Background: Studies investigating the relationship between egg consumption and the risk of cerebrovascular disease (CED) have yielded inconsistent results. This study evaluated the association between egg consumption and the risk of CED among Chinese adults. Methods: Data were obtained from China Kadoorie Biobank, Qingdao. A computerised questionnaire was used to collect information regarding egg consumption frequency. CED events were tracked through linkage with the Disease Surveillance Point System and the new national health insurance databases. Cox proportional hazards regression analyses were used to evaluate associations between egg consumption and CED risk controlling for potential confounders. Results: After a median follow-up of 9.2 years, 865 and 1083 CED events among men and women, respectively, were documented. More than 50% of participants consumed eggs daily with an average age of 52.0 (10.4) years at baseline. No association between egg consumption and CED were identified in the whole cohort and women. However, a 28% lower risk of CED was observed in those who consumed eggs at a higher frequency (HR = 0.72, 95% CI: 0.55–0.95) and a significant trend for the association (p for trend = 0.012) in a multivariable model in men. Conclusion: Higher frequency of egg consumption was associated with a lower risk of total CED events among men but not women in Chinese adults. The beneficial effect on women warrants further investigations.

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Section: Discussionmentioning

confidence: 99%

The Prospective Associations of Egg Consumption with the Risk of Total Cerebrovascular Disease Morbidity among Chinese Adults

et al. 2023

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“…Twelve meta-analyses described blood pressure as a risk factor. For stroke incidence, effect sizes ranged from 1.22 (95%CI:0.95-1.57) -1.66 (95%CI:1.51-1.81) for low pre-hypertension (120-129/80-84mmHg), 1.79 (95%CI:1.49-2.16) -1.95 (95%CI:1.73-2.21) for high pre-hypertension (130-139/85-80 mmHg) and 2.23 (95%CI:2.01-2.48) -10.92 (95%CI:7.07-16.86) for hypertension (>140/90 mmHg) (reference blood pressure < 120/80 mmHg) 36,[43][44][45][46][47][48] . For dementia incidence, effect sizes for hypertension ranged from 0.98 (95%CI:0.72-1.33) -1.41 (95%CI:1.23-1.62) [49][50][51][52] .…”

Section: Blood Pressurementioning

confidence: 99%

Modifiable Risk Factors for Stroke, Dementia, and Late-Life Depression: A Systematic Review and DALY Weighted Risk Factors for a Composite Outcome

Senff,

Tack,

Mallick

et al. 2024

Preprint

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BackgroundAt least 60% of stroke, 40% of dementia, and 35% of late-life depression (LLD) are attributable to modifiable risk factors, with great overlap due to a shared underlying pathophysiology. This study aims to systematically identify overlapping risk factors for these diseases and calculate their relative impact on a composite outcome.MethodsA systematic literature review was performed in Pubmed, Embase, and PsycInfo, between January 2000 and September 2023. We included meta-analyses reporting effect sizes of modifiable risk factors on the incidence of stroke, dementia, and/or LLD. The most relevant meta-analyses were selected, and Disability Adjusted Life Year (DALY) weighted beta-coefficients were calculated for a composite outcome. The beta-coefficients were then normalized to assess relative impact.ResultsOur search yielded 182 meta-analyses meeting the inclusion criteria, of which 59 were selected to calculate DALY-weighted risk factors for a composite outcome. Identified risk factors included alcohol use (normalized beta-coefficient highest category: -20), blood pressure (87), BMI (42), fasting plasma glucose (57), total cholesterol (14), leisure time cognitive activity (-54), depressive symptoms (34), diet (27), hearing loss (35), kidney function (60), pain (25), physical activity (-34), purpose in life (-30), sleep (44), smoking (58), social engagement (32), and stress (32).DiscussionThis study identified overlapping modifiable risk factors and calculated the relative impact of these factors on the risk of a composite outcome of stroke, dementia, and LLD. These findings could guide preventative strategies and serve as an empirical foundation for future development of tools that can empower people to reduce their risk of these diseases.FundingUS National Institutes of Health and American Heart Association.

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“…The major risk factors contributing to the CVD epidemic in Asia are the result of an intricate interplay between socioeconomic and living conditions, demographics, lifestyles, the prevalence of CVD risk factors, and the capacity to achieve prevention and treatment goals. In China, the risk factors for CVD and CBD in young people include obesity, current smoking, atrial fibrillation, hypertension, systolic blood pressure, and total cholesterol, while triglycerides serve as protective factors for CVD and CBD in young and middle-aged individuals [13]. A cross-sectional study showed significant variations in the prevalence of hypertension (24.5% in China, 17.6% in Korea, and 15.2% in Japan) and DM (8.9% in China, 5.7% in Korea, and 4.8% in Japan).…”

Section: Risk Factors Of Cvd and Cbdmentioning

confidence: 99%

Trends and Diversity of Cardiovascular Disease (CVD) Mortality and Risk Factors in Five Asian Countries

Lin¹,

Lin²,

Liang³

et al. 2023

Preprint

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We explored the trends and the diversity of the mortality and risk factors of age-standardized cardiovascular diseases (CVD) and cerebrovascular disease (CBD) from 2000 to 2020 in five advanced Asian countries, including China, Japan, Singapore, South Korea, and Taiwan. Data were obtained from the Global Burden of Disease (GBD) report. Overall, the CVD mortality rates decreased gradually in all five Asian countries. Singapore had the highest rates before 2011, but Taiwan replaced Singapore as the nation of the highest mortality rates after 2012. Additionally, South Korea had the highest CBD mortality rates before 2016, while Taiwan experienced a peak in 2011 and remained high thereafter. The absolute difference (AD) and relative difference (RD) for CVD mortality rates showed clear declining trends in all five countries, with South Korea and China displaying the highest reductions, respectively. It is noteworthy that overweight and obesity exhibited an increasing trend in all these five Asian countries, with China demonstrating the highest AD and RD. Except for Taiwan, where a negative association of r=-0.732 was observed, CVD mortality was positively associated with CBD, hypertension, and DM mortality in all other four countries, therefore, further investigation into these relationships are needed.

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Risk factors of cardiovascular and cerebrovascular diseases in young and middle-aged adults: A meta-analysis

Cited by 11 publications

References 42 publications

The Prospective Associations of Egg Consumption with the Risk of Total Cerebrovascular Disease Morbidity among Chinese Adults

The Prospective Associations of Egg Consumption with the Risk of Total Cerebrovascular Disease Morbidity among Chinese Adults

Modifiable Risk Factors for Stroke, Dementia, and Late-Life Depression: A Systematic Review and DALY Weighted Risk Factors for a Composite Outcome

Trends and Diversity of Cardiovascular Disease (CVD) Mortality and Risk Factors in Five Asian Countries

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