Risk factors of female cancers in ragusa population (sicily) - I. Endometrium and cervix uteri cancers

Cusimano, Rosanna; Dardanoni, Gabriella; Dardanoni, L; Rosa, Massimo La; Pavone, G.; Tumino, Rosario; Gafà, Lorenzo

doi:10.1007/bf00144839

Cited by 13 publications

(16 citation statements)

References 29 publications

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“…Thus, hospital controls may not be representative of the general population. However, we selected controls in the major teaching and general hospitals of the area under Cusimano et al, 1989Kato et al, 1989Webster & Weiss, 1989Shu et al, 1991Austin et al, 1993Levi et al, 1993Swanson et al, 1993Parazzini et al, 1995Hirose et al, 1996Kalandidi et al, 1996 surveillance and excluded from the comparison group hysterectomized women and any patients admitted to hospital for any chronic and gynecological conditions. Over one-third of our controls had traumas, but the results were similar when comparison was made across major diagnostic categories of controls.…”

Section: Discussionmentioning

confidence: 99%

“…former)-drinkers was 0.93 (95% CI 0.85-1.01), and the one from four studies, including the present one [8,33,36], considering ever versus never drinkers was 1.08 (95% CI 0.87-1.33), with no significant heterogeneity (p = 0.201). According to geographic area, we found a pooled RR for drinkers compared to non/low drinkers of 0.90 (95% CI 0.80-1.02) from 11 studies from North America [5,6,12,15,16,31,33,[35][36][37]48], 1.00 (95% CI 0.90-1.11) from five studies from northern Europe [9, 10, 13, 14, 38], 1.07 (95% CI 0.88-1.30) from six studies from southern Europe, including the present one [8,28,32,34,39], and 0.80 (95% CI 0.59-1.08) from four studies from Asia [29,30,47], with no statistically significant heterogeneity across geographic regions (p = 0.245).…”

Section: Meta-analysismentioning

confidence: 99%

“…We defined ''heavy alcohol drinkers'' as those women consuming C14 drinks/week, on the basis of the higher cut-points of most published data. Thus, 17 studies providing no risk estimate for heavy alcohol drinking [6,10,14,15,[28][29][30][31][32][33][34][35][36][37][38][39][40] were excluded from the analysis comparing heavy drinkers versus non/low drinkers.…”

Section: Meta-analysismentioning

confidence: 99%

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Alcohol and endometrial cancer risk: a case–control study and a meta-analysis

Turati

Gallus

Tavani

et al. 2010

Cancer Causes Control

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To evaluate the association between alcohol consumption and endometrial cancer risk, we analyzed data from a hospital-based case-control study, conducted in Italy between 1992 and 2006, on 454 endometrial cancer cases and 908 controls, and performed a meta-analysis updated to October 2009. Compared to never alcohol drinkers, the odds ratio was 1.03 (95% confidence interval, CI, 0.76-1.41) for < or = 7, 1.27 (95% CI 0.86-1.87) for 8-14, and 1.19 (95% CI 0.80-1.77) for > or = 15 drinks/week, with no trend in risk. No association emerged for wine, beer, and spirit consumption analyzed separately. The meta-analysis included 20 case-control and seven cohort studies, for a total of 13,120 cases. Compared to non/low drinkers, the pooled relative risks for drinkers were 0.90 (95% CI 0.80-1.01) for case-control studies, 1.01 (95% CI 0.90-1.14) for cohort studies, and 0.95 (95% CI 0.88-1.03) overall, with no heterogeneity between study design (p = 0.156). The overall estimate for heavy versus non/low drinkers was 1.12 (95% CI 0.87-1.45). The results were consistent according to selected study characteristics, including geographic area, definition of alcohol drinkers, and type of controls in case-control studies. Our findings provide evidence that alcohol drinking is not associated with endometrial cancer risk, although a weak positive association for very high drinkers cannot be excluded.

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Section: Discussionmentioning

confidence: 99%

Section: Meta-analysismentioning

confidence: 99%

Section: Meta-analysismentioning

confidence: 99%

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Alcohol and endometrial cancer risk: a case–control study and a meta-analysis

Turati

Gallus

Tavani

et al. 2010

Cancer Causes Control

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“…Twenty women selected as controls refused to be interviewed; in this case another control was chosen on the same basis. D a t a c o l l e c t i o n -Details on the method for interviews are reported in the accompanying paper (7). Briefly, between February and May 1986 all interviews were conducted by trained personnel using the same structured questionnaire for cases and controls.…”

Section: Introduction Materials and Methodsmentioning

confidence: 99%

“…Variables are listed in Tables 2-7. The assessment of socio-economic status, and of tobacco and alcohol consumption is reported in the accompanying paper (7). D a t a a n a l y s i s -The significance of differences between cases and controls in the distribution of each variable was assessed by means of the Chi square test and, when appropriate, by the Chi square test for trend (2).…”

Section: Introduction Materials and Methodsmentioning

confidence: 99%

Risk factors of female cancers in Ragusa population (Sicily). 2. Breast cancer

Cusimano

Dardanoni

et al. 1989

Eur J Epidemiol

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A case-control study on breast, cervix and corpus uteri cancer cases registered in Ragusa between January 1, 1983 and June 30, 1985 has been conducted. Information on risk factors has been obtained by means of a structured questionnaire. Risk factors for breast cancer were: few pregnancies (1-2 vs greater than 4 OR 2.14, 95% CL 1.13-4.04), few children (for postmenopausal only, chi trend 4.84), previous breast disease (OR 1.97, 95% CL 1.20-3.23), family history (OR 3.57, 95% CL 1.92-6.63), alcohol (OR 1.68, 95% CL 1.12-2.53), high socioeconomical status (1 vs 4 OR 2.93, 95% CL 1.22-70.03). A protective role was evident for: early age at first birth (for premenopausal only, less than 20 vs greater than 20 OR 0.11, 95% CL 0.01-0.90), previous ovary disease (OR 0.26, 95% CL 0.08-0.88). Age at menarche, age at menopause, years of fertile life and breast feeding were not found to be related to breast cancer. A different distribution of risk factors among cases with and without family history has been suggested. A synoptic table shows the distribution of the most important risk factors of the three investigated female cancers in the Ragusa population, reported in the present and in an accompanying paper.

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Meta‐analysis of social inequality and the risk of cervical cancer

Parikh

Brennan

Boffetta

2003

Intl Journal of Cancer

214

127

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Previous studies of the relationship between socio-economic status and cervical cancer have been mainly based on record linkage of routine data, such as cancer registry incidence rates and regional measures of social class based on census data. These routine data are liable to substantial misclassification with respect to socio-economic status. Previous reports are also primarily from developed countries, whereas the major burden of cervical cancer is in developing countries. We have therefore pooled the data from previously reported case-control studies of cervical cancer or dysplasia, which contain individual-level information on socioeconomic characteristics to investigate the relationship between cervical cancer, social class, stage of disease, geographical region, age and histological type. Based on 57 studies, we found an increased risk of approximately 100% between high and low social class categories for the development of invasive cervical cancer, and an increased risk of approximately 60% for dysplasia, including carcinoma in situ. Although the difference was observed in all countries, it was stronger in low/middle income countries and in North America than in Europe. No clear differences were observed between squamous cell carcinoma and adenocarcinoma, or between younger and older women. These results indicate that both cervical infection with human papillomavirus, which is linked to both female and male sexual behaviour, and access to adequate cervical cancer screening programmes are likely to be important in explaining the large cervical cancer incidence rates observed in different socioeconomic groups, and that the importance of these factors may vary between different geographical regions. © 2003 Wiley-Liss, Inc. Key words: meta-analysis; cervical cancerCervical cancer is the third most common cancer among women world-wide with an estimated 471,000 cases and 230,000 deaths occurring per year, more than 80% of which occur in developing countries. 1 An overview of 21 published studies reported a consistent increasing trend in cervical cancer incidence with various indicators of decreasing social class, including level of education, income and occupation. 2 The main explanations advanced for the excess risk among lower socio-economic groups are related to sexual behaviour, corresponding to a greater chance to acquire and/or become chronic carriers of human papillomavirus (HPV), which is a necessary cause of cervical cancer. Less access to early diagnosis or cytological screening for cervical cancer is also likely to result in a higher incidence and mortality.One problem highlighted by the overview of previous studies was that the majority have been based on record linkage between mortality or cancer registry incidence data and regional measures of social class based on census data. These routine data are usually not collected at the individual level and are liable to substantial misclassification. In addition, the studies are primarily from Western Europe and North America, whereas the major burden o...

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Risk factors of female cancers in ragusa population (sicily) - I. Endometrium and cervix uteri cancers

Cited by 13 publications

References 29 publications

Alcohol and endometrial cancer risk: a case–control study and a meta-analysis

Alcohol and endometrial cancer risk: a case–control study and a meta-analysis

Risk factors of female cancers in Ragusa population (Sicily). 2. Breast cancer

Meta‐analysis of social inequality and the risk of cervical cancer

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