Risk Factors of Gastric Cancer and Lifestyle Modification for Prevention

Ko, Kwang-Pil

doi:10.5230/jgc.2024.24.e10

Cited by 11 publications

(2 citation statements)

References 41 publications

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“…Gastric cancer is the fourth most common cancer in the world, with approximately 1.03 million deaths in 2022 [1][2][3][4]. It remains difficult for gastric cancer patients to be effectively cured because most of them find the cancer at an advanced stage [5].…”

Section: Introductionmentioning

confidence: 99%

Micro gas chromatography column using ionic liquid modified metal-organic framework as stationary phase for rapid breath analysis of gastric cancer

Hu,

Wang,

Yan

et al. 2024

J. Inst.

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The micro gas chromatography columns (μGCs) were prepared for rapid breath analysis of gastric cancer. The synergistic effect of the specific surface area and the action of pore diameter on the separation capacity was investigated. The μGC-IL/UIO-66 was prepared using [P66614][Cl]/UIO-66 as the stationary phase. For comparison, the μGC-IL and the μGC-UIO-66 were prepared using [P66614][Cl] and UIO-66 as stationary phase, respectively. [P66614][Cl]/UIO-66 had a high specific surface area with a pore diameter distribution of 0.49 nm. The high specific surface area of [P66614][Cl]/UIO-66 improved the efficiency of adsorption and desorption, while the porous structure with an appropriate pore diameter acted as an efficient molecular sieve, synergistically enhancing separation efficiency. So compared to the μGC-IL and the μGC-UIO-66, the HETP of μGC-IL/UIO-66 was reduced by 68.2% and 22.6%, respectively. In the analysis of volatile biomarkers (acetone, benzene, n-hexane and toluene) for gastric cancer, the resolutions between adjacent peaks were 1.96, 2.13 and 3.67, which met the requirements for quantitative analysis (R > 1.5). The retention times of acetone, benzene, n-hexane and toluene were 0.72 min, 0.96 min, 1.33 min and 1.67 min, which enables rapid analysis. All may suggest that the μGC-IL/UIO-66 has a promising application in rapid breath analysis of gastric cancer.

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Section: Introductionmentioning

confidence: 99%

Micro gas chromatography column using ionic liquid modified metal-organic framework as stationary phase for rapid breath analysis of gastric cancer

Hu,

Wang,

Yan

et al. 2024

J. Inst.

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“…Gastric cancer (GC) is the fifth most frequently diagnosed malignant cancer and the fourth leading cause of cancer-related deaths worldwide, with more than one million new cases and approximately 770,000 deaths in 2020 ( 1 , 2 ). Host-related factors, including genetic predisposition, environmental exposure factors, and microbial infections, contribute to gastric tumorigenesis ( 3 , 4 ). Helicobacter pylori ( H. pylori ) infection plays a crucial role in mucosal inflammation, induces histological changes, and promotes the degradation of the architecture and integrity of the gastric epithelium, which is recognized as an important etiological factor of GC ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Distinct oral-associated gastric microbiota and Helicobacter pylori communities for spatial microbial heterogeneity in gastric cancer

Lei,

Zhao,

Cheng

et al. 2024

mSystems

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The gastric microbial community plays a fundamental role in gastric cancer (GC), and the two main anatomical subtypes of GC, non-cardia and cardia GC, are associated with different risk factors ( Helicobacter pylori for non-cardia GC). To decipher the different microbial spatial communities of GC, we performed a multicenter retrospective analysis to characterize the gastric microbiota in 223 GC patients, including H. pylori -positive or -negative patients, with tumors and paired adjacent normal tissues, using third-generation sequencing. In the independent validation cohort, both dental plaque and GC tumoral tissue samples were collected and sequenced. The prevalence of H. pylori and oral-associated bacteria was verified using fluorescence in situ hybridization (FISH) assays in GC tumoral tissues and matched nontumoral tissues. We found that the vertical distribution of the gastric microbiota, at the upper, middle, and lower third sites of GC, was likely an important factor causing microbial diversity in GC tumor tissues. The oral-associated microbiota cluster, which included Veillonella parvula , Streptococcus oralis , and Prevotella intermedia , was more abundant in the upper third of the GC. However, H. pylori was more abundant in the lower third of the GC and exhibited a significantly high degree of microbial correlation. The oral-associated microbiota module was co-exclusive with H. pylori in the lower third site of the GC tumoral tissue. Importantly, H. pylori -negative GC patients with oral-associated gastric microbiota showed worse overall survival, while the increase in microbial abundance in H. pylori -positive GC patients showed no difference in overall survival. The prevalence of V. parvula in both the dental plaque and GC tissue samples was concordant in the independent validation phase. We showed that the oral-associated species V. parvula and S. oralis were correlated with overall survival. Our study highlights the roles of the oral-associated microbiota in the upper third of the GC. In addition, oral-associated species may serve as noninvasive screening tools for the management of GC and an independent prognostic factor for H. pylori -negative GCs. IMPORTANCE Our study highlights the roles of the oral-associated microbiota in the upper third of gastric cancer (GC).We showed that the oral-associated species Veillonella parvula and Streptococcus oralis were correlated with overall survival. In addition, oral-associated species may serve as noninvasive screening tools for the management of GC and an independent prognostic factor for Helicobacter pylori -negative GCs.

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Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis

Li,

Zhang,

Pan

et al. 2024

Advanced Science

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The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the impact of individual differences in health management on cancer. However, increasing evidence suggests that individual psychological status, dietary habits, and exercise frequency are closely related to the risk and prognosis of cancer. The reminder to humanity is that the medical concept of the unified treatment plan is insufficient in cancer treatment, and a personalized treatment plan may become a breakthrough point. On this basis, the concept of “Humanistic Health Management” (HHM) is proposed. This concept is a healthcare plan that focuses on self‐health management, providing an accurate and comprehensive evaluation of individual lifestyle habits, psychology, and health status, and developing personalized and targeted comprehensive cancer prevention and treatment plans. This review will provide a detailed explanation of the relationship between psychological status, dietary, and exercise habits, and the regulatory mechanisms of cancer. Intended to emphasize the importance of HHM concept in cancer prevention and better prognostic efficacy, providing new ideas for the new generation of cancer treatment.

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Risk Factors of Gastric Cancer and Lifestyle Modification for Prevention

Cited by 11 publications

References 41 publications

Micro gas chromatography column using ionic liquid modified metal-organic framework as stationary phase for rapid breath analysis of gastric cancer

Micro gas chromatography column using ionic liquid modified metal-organic framework as stationary phase for rapid breath analysis of gastric cancer

Distinct oral-associated gastric microbiota and Helicobacter pylori communities for spatial microbial heterogeneity in gastric cancer

Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis

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