Risk factors of hemorrhagic transformation after thrombolysis in ischemic stroke patients in Tyumen district

Abstract

Aim: identification of risk factors of hemorrhagic transformation (HT) after intravenous thrombolytic therapy. Patients and methods: the study included 100 medical records of patients, who underwent thrombolytic therapy. Patients were divided into two groups according to the outcome: 89 patients with HT and 11 patients without HT. Clinical and demographic characteristics of patients were analyzed, including neurological status assessment using NIHSS, Rankin, Rivermead and Waterloo scales. Results: among patients with HT 54.5% were smokers, compared to 29.2% in no HT group (p < 0.05). Significant differences in Rankin, Rivermead and Waterloo scales on admission, after the intervention and at discharge were observed (p < 0.05). Conclusion: smoking is as a significant risk factor of HT, which should be taken into account in the development of thrombolytic therapy programs.