Risk factors of interstitial lung diseases in patients with rheumatoid arthritis

Klester, Elena; Klester, Karolina; Shoikhet, Ya. N.; Elykomov, Valeriy; Yarkova, Valentina; Berdyugina, Antonina; Mukhtarova, Etiborhon

doi:10.1183/13993003.congress-2019.pa1365

Cited by 5 publications

(11 citation statements)

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“…For example, some studies found male sex to be associated with RA‐ILD (4,24), but others, including ours, did not (10,27,28,30,31). Similarly, smoking has been associated with RA‐ILD in some studies (4,11,27,29,32) but not others (10,24,28,30,31). Further, in contrast to some studies (27,29–31), our study and others (10,24,31) did not demonstrate an association between seropositivity and RA‐ILD.…”

Section: Discussionmentioning

confidence: 96%

“…Similarly, smoking has been associated with RA‐ILD in some studies (4,11,27,29,32) but not others (10,24,28,30,31). Further, in contrast to some studies (27,29–31), our study and others (10,24,31) did not demonstrate an association between seropositivity and RA‐ILD. Interestingly, based on a male‐predominant cohort of US veterans (89% male) with RA, Natalini and colleagues (33) recently reported that combined RF/ACPA seropositivity was associated with prevalent RA‐ILD (i.e., ILD identified prior to or within 12 months after RA onset), but not incident RA‐ILD (i.e., ILD identified more than 12 months after RA onset).…”

Section: Discussionmentioning

confidence: 96%

“…We have found that ever smoking (current or previous) and age at the time of RA incidence, along with the presence of severe EAMs, are the major predictors of incident ILD. Older age at RA onset has been associated with generally worse outcomes (25,26) and has been consistently identified as a predictor of RA-ILD (4,6,10,24,(27)(28)(29)(30). Nevertheless, the association between RA-ILD and all other variables is less compelling.…”

Section: Discussionmentioning

confidence: 99%

“…Older age at RA onset has been associated with generally worse outcomes (25,26) and has been consistently identified as a predictor of RA‐ILD (4,6,10,24,27–30). Nevertheless, the association between RA‐ILD and all other variables is less compelling.…”

Section: Discussionmentioning

confidence: 99%

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Incidence, Risk Factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Population‐Based Cohort

Samhouri

Vassallo

Achenbach

et al. 2022

Arthritis Care & Research

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To identify the incidence, risk factors, and outcomes of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and to assess time trends in the incidence and mortality in RA-ILD.Methods. We included adult residents of Olmsted County, Minnesota with incident RA between 1999 and 2014. Subjects were followed until death, emigration, or April 30, 2019. ILD was defined as the presence of a radiologistdefined pattern consistent with ILD on chest computed tomography (CT). When chest CT was absent, the combination of chest radiograph abnormalities compatible with ILD and restrictive pattern on pulmonary function testing was considered consistent with ILD. Potential risk factors included age, sex, smoking, obesity, seropositivity, extraarticular manifestations (EAMs), and medications. For survival analysis, we matched RA-ILD patients to RA-non-ILD comparators. The frequency and mortality from clinician-diagnosed RA-ILD from 1999 to 2014 was compared against a cohort from 1955 to 1994.Results. During the 1999-2014 time period, 645 individuals (70% women) had incident RA, were a median age of 55.3 years, and 53% never smoked. Twenty-two patients had ILD before RA, and 51 (67% women) developed ILD during follow-up. The 20-year cumulative incidence of RA-ILD was 15.3%. Ever-smoking (hazard ratio [HR] 1.92), age at RA onset (HR 1.89 per 10-year increase), and severe EAMs (HR 2.29) were associated with incident RA-ILD. The RA-ILD cases had higher mortality than their matched RA comparators (HR 2.42). Incidence of RA-ILD was nonsignificantly lower from 1999 to 2014 than from 1955 to1994, but mortality was improved.Conclusions. RA-ILD occurs in nearly 1 in 6 patients with RA within 20 years and is associated with shorter survival. Lack of significant change in RA-ILD incidence over 6 decades deserves further investigation.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Incidence, Risk Factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Population‐Based Cohort

Samhouri

Vassallo

Achenbach

et al. 2022

Arthritis Care & Research

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“…ACPA positivity at titres >15 U/mL, as well as combined RF and ACPA positivity regardless of titre, were also associated with ILD. In cross-sectional studies reporting analyses adjusted for other baseline factors, Wang and Du 27 demonstrated an association of ACPA positivity with ILD and Klester et al 28 an association of RF positivity with ILD, while Yang et al 29 and Salaffi et al 30 found ACPA titre, but not positivity, to be associated with ILD. Juge et al 15 showed no association between RF and ACPA with ILD.…”

Section: Resultsmentioning

confidence: 99%

Patient-level factors predictive of interstitial lung disease in rheumatoid arthritis: a systematic review

et al. 2023

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ObjectiveInterstitial lung disease (ILD) is an important cause of mortality in some patients with rheumatoid arthritis (RA). Patient-level factors may predict which patients with RA are at the highest risk of developing ILD and are therefore candidates for screening for this complication of the underlying disease.MethodsA systematic literature review was performed using PubMed, Embase and Scopus over a 10-year period up to July 2021. Publications reporting patient-level factors in patients with RA with and without ILD that were assessed before development of ILD (or were unchanged over time and therefore could be extrapolated to before development of ILD) were retrieved for assessment of evidence. Genetic variation inMUC5Band treatment with methotrexate were not included in the assessment of evidence because these factors have already been widely investigated for association with ILD.ResultsWe found consistent associations of age, sex, smoking status and autoantibodies with development of ILD. For biomarkers such as Krebs von den Lungen 6, which have been shown to be diagnostic for ILD, there were no publications meeting criteria for this study.ConclusionsThis analysis provides an initial step in the identification of patient-level factors for potential development of a risk algorithm to identify patients with RA who may be candidates for screening for ILD. The findings represent a useful basis for future research leading to an improved understanding of the disease course and improved care for patients with RA at risk of development and progression of ILD.

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Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Kim,

Yang,

Kim

2023

Preprint

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Interstitial lung disease (ILD) is one of the most serious extra-articular complications of rheu-matoid arthritis (RA), which increases the mortality of RA. Because the pathogenesis of RA-ILD remains poorly understood, appropriate therapeutic strategies and biomarkers have not yet been identified. Thus, the goal of this review was to summarize and analyze the reported data on the etiology and pathogenesis of RA-ILD. The incidence of RA-ILD increases with age, and is also generally higher in men than in women and in patients with specific genetic variations and eth-nicity. Lifestyle factors associated with an increased risk of RA-ILD include smoking and exposure to pollutants. The presence of an anti-cyclic citrullinated peptide antibody, high RA disease activity, and rheumatoid factor positivity also increase the risk of RA-ILD. We also explored the roles of biological processes (e.g., fibroblast–myofibroblast transition, epithelial–mesenchymal transition, and immunological processes), signaling pathways (e.g., JAK/STAT and PI3K/Akt), and the his-topathology of RA involved in RA-ILD pathogenesis based on published preclinical and clinical models of RA-ILD in animal and human studies.

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Risk factors of interstitial lung diseases in patients with rheumatoid arthritis

Cited by 5 publications

References 0 publications

Incidence, Risk Factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Population‐Based Cohort

Incidence, Risk Factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Population‐Based Cohort

Patient-level factors predictive of interstitial lung disease in rheumatoid arthritis: a systematic review

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

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