Risk factors of low vitamin D status in adolescent females in Kuwait: implications for high peak bone mass attainment

Alyahya, Khulood Othman; Lee, Warren T K; Al-Mazidi, Z; Morgan, Jane; Lanham-New, Susan A

doi:10.1007/s11657-014-0178-z

Cited by 20 publications

(24 citation statements)

References 40 publications

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“…Invitation letters were sent to the mothers of students from a previous study38 who were recruited from schools located in each governorate in Kuwait. In addition, female students in the College of Basic Education, Public Authority for Applied Education and Training, Kuwait were also invited to participate.…”

Section: Methodsmentioning

confidence: 99%

Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women

Azizieh

Alyahya

Dingle

2017

JIR

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BackgroundAlthough a large number of studies have investigated possible relationships among serum levels of vitamin D or cytokines with disease progress and prognosis, similar studies on self-reported symptoms are still controversial. The overall objective of this study was to look into the association between serum levels of vitamin D or cytokines with self-reported symptoms related to musculoskeletal pain, sleep disorders, and premenstrual syndrome (PMS) in healthy adult women.Subjects and methodsVenous blood samples were collected from 117 healthy adult women, and serum levels of vitamin D, pro-inflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, IFN-γ, and TNF-α) and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were measured. Groups were tested for differences in single parameters, pro-:anti-inflammatory cytokine ratios, and differences in multivariate patterns.ResultsThere were no significant associations between serum levels of vitamin D and any of the self-reported symptoms studied. However, serum levels of certain pro-inflammatory cytokines were significantly higher in subjects with musculoskeletal pain (IL-8, P=0.008), sleep disorders (IFN-γ, P=0.02), and PMS (IL-8 and TNF-α, P=0.009 and 0.002, respectively) compared to subjects who reported no symptoms. The pro-:anti-inflammatory cytokine ratios showed pro-inflammatory cytokine dominance in subjects with self-reported symptoms, particularly in the groups with deficient levels of vitamin D. However, the multivariate cytokine-pattern analysis was significantly different between PMS groups only.ConclusionThese data point to a possible role of pro-inflammatory cytokines as a contributing factor in self-reported symptoms related to musculoskeletal pain, sleep disorders, and PMS.

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Section: Methodsmentioning

confidence: 99%

Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women

Azizieh

Alyahya

Dingle

2017

JIR

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“…21, 22, 23, 24, 25, 26 For example, a Kuwaiti and an Emirati study reported that ~98 and 83% (respectively) of the participants had serum 25(OH)D less than 20 ng ml −1 . 24, 25 Studies thus far conducted in Qatar on vitamin D were specific to a certain population (elderly and health professionals). At the same time, the prevalence of MetS was measured to be ~26.5%, according to the International Diabetes Federation (IDF) criteria, amongst Qataris aged 20 and over.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population

et al. 2017

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Objectives:Despite long hours of sunlight in Qatar and other regions of the Middle East, vitamin D deficiency has been rising. In parallel, the prevalence of metabolic syndrome has also been increasing in Qatar. Vitamin D levels have been associated with metabolic syndrome but the data are inconsistent and no studies have addressed these inter-relationships in a Middle Eastern population where the prevalence of these conditions is high. The objective is to investigate the prevalence of vitamin D deficiency and its association with metabolic syndrome and its components in the Qatar Biobank population.Methods:A cross-sectional study of 1205 participants (702 women and 503 men) from the Qatar Biobank, comprising Qataris and non-Qataris between the ages of 18 and 80 years, was used to perform multivariate linear regression analyses to examine the association between metabolic syndrome and prevalence of vitamin D deficiency (defined as <20 ng ml−1 serum vitamin D levels) adjusting for age, sex, ethnicity, season of blood collection, physical activity and education. Odds ratios and 95% confidence intervals were calculated for all analyses.Results:Approximately 64% of participants were vitamin D deficient (<20 ng ml−1) with more men being deficient (68.6%) than women (61.3%). Serum vitamin D was 8% lower in individuals with metabolic syndrome (RR: 0.92, 95%CI: 0.87–0.98, P-value: 0.01) compared to individuals without metabolic syndrome. Waist circumference and HDL as well as high triglyceride levels were also significantly positively associated with vitamin D deficiency. No association was found between the other components of metabolic syndrome or diabetes and the presence of vitamin D deficiency.Conclusions:Vitamin D deficiency is prevalent in this Qatari population. Presence of metabolic syndrome was associated with presence of vitamin D deficiency. Future prospective studies need to be conducted to investigate the potential for causality.

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“…While Kuwait is blessed with ambient sunshine all over the year, it is possible that the lifestyle and the harsh hot weather during the long summer discourage daily exposure to the sun, needed to maintain adequate vitamin D levels and bone quality. Approximately 86% of Kuwaiti females were reported to show hypovitaminosis D,26 and up to 60% of neonates had undetectably low vitamin D levels at delivery 27…”

Section: Discussionmentioning

confidence: 99%

Fractures in Kuwait: incidence and distribution

Azizieh

2017

RMHP

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The absence of descriptive epidemiological data on the frequency and distribution of fractures in a population is serious and may underestimate the actual importance of this public health problem. In this study, we report the crude and standardized incidence rates of fractures in the population of Kuwait during the period 2009–2012. Using the Ministry of Public Health’s national registry, demographic data of all fracture cases between 2009 and 2012 were retrieved. These were further categorized into fractures at the hip or any other sites. Average annual incidence rates were calculated and standardized using the world’s population in 2010 as a reference. Thus, 18,119 fractures among males and 6,362 among females were recorded. The overall estimated annual incidence rates of fractures per 100,000 person-years were 207 for males and 111.8 for females. Moreover, 13.3% of all fractures were in the hip, with incidence rates of 24.8 for males and 18.9 for females; while 86.7% were in other sites, with corresponding incidence rates of 182.2 and 92.8, respectively. The age-specific fracture incidence rates in females remained below the corresponding rates of males until ≥50 years of age, after which the female age groups showed successively higher rates. The age-standardized incidence rates for all fractures (hip and other sites) were 247.4 for males, 175.4 for females, and 216.2 for both sexes. The burden of this major public health challenge is set to rise, and such population-based incidence data call for an urgent need for action to reduce the projected human impact and socioeconomic costs of fracture.

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Risk factors of low vitamin D status in adolescent females in Kuwait: implications for high peak bone mass attainment

Abstract: Low vitamin D status is prevalent in Kuwaiti adolescent females, which may have a negative impact on their bone mineralization and accrual. Further investigation is needed to reveal the underlying causes.

Cited by 20 publications

References 40 publications

Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women

Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women

Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population

Fractures in Kuwait: incidence and distribution

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