Risk factors of new symptomatic vertebral compression fractures in osteoporotic patients undergone percutaneous vertebroplasty

Abstract

The incidence of new symptomatic VCFs after PVP was higher in osteoporotic patients with initial multiple-level fractures.

Risk factors for new vertebral compression fractures after vertebroplasty: a meta‐analysis

“…found that the presence of more than two pre‐existing VCFs was the only independent risk factor for new VCFs. Ren et al . confirmed that the number of levels of initial symptomatic fractures was positively correlated with the incidence of new fractures; additionally, the risk of new fractures increased 2.518‐fold with the number of initial VCFs.…”

“…After reviewing the full text of the remaining 26 studies, we excluded nine additional full‐text articles. Finally, 17 unique studies with sufficient data were included and analysed in the meta‐analysis . A flow diagram that shows the literature search process is presented in Figure .…”

“…The descriptive statistics for the studies that were included in our meta‐analysis are summarized in Table . Of the studies, eight were conducted in China, six were conducted in Korea, one was conducted in the Netherlands, one was conducted in Japan and one was conducted in Spain . The results of the quality assessment are summarized as follows: two studies received a score of 9, eight studies received a score of 8, five studies received a score of 7 and two studies received a score of 6.…”

“…The 17 studies included 521 cases and 1774 controls, for a total of 2295 participants. Of the studies, 15 reported the incidence of new VCFs after vertebroplasty. The reported incidence of subsequent VCFs following vertebroplasty ranged from 6.81 to 37.95%.…”

“…To the best of our knowledge, prior studies have investigated many of the risk factors for the development of new VCFs following vertebroplasty, such as low body mass index (BMI), intradiscal cement leakage, high cement volume, low bone mineral density (BMD) and multiple vertebral levels affected . However, these studies were limited by either a small sample size or a limited number of potential risk factors investigated.…”