Risk factors of outcomes in elderly patients with acute ischemic stroke in China

Qi, Weimin; Zou, Chunying; Wu, Chengji; Zhang, Shuping; Huang, Zhi‐Zhen

doi:10.1007/s40520-015-0478-1

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Several studies showed that low-level of cholesterol was significantly associated to the poor outcome after acute ischemic stroke 12–14 . Similarly, a previous study showed that a lower cholesterol level was associated with an increased risk of death among elderly patients with ischemic stroke 15 .…”

Section: Discussionmentioning

confidence: 99%

“…All patients in this study were identified from the stroke registry of the Department of Neurology, Jiamusi University First Hospital, China between January 2008 and December 2016. The inclusion criteria of participants and study design have been described previously 12 . In brief, all consecutive patients with first-ever acute ischemic stroke who were admitted to the Department of Neurology, Jiamusi University First Hospital within 72 hours of stroke onset were recruited for this study.…”

Section: Methodsmentioning

confidence: 99%

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Prognosis and Associated Factors among Elderly Patients with Small Artery Occlusion

Zhao

Yang

Yan

et al. 2019

Sci Rep

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Small artery occlusion (SAO) is the one of the primary subtype of ischemic stroke in China. However, its outcomes among elderly patients are unclear. Consecutive patients with SAO were recruited at Jiamusi University First Hospital, China between January 2008 and December 2016. Stroke subtype, severity, and risk factors were collected; outcomes at 3, 12, and 36 months after stroke onset were assessed. A total of 1464 SAO patients were included in this study. Participants aged ≥75 years had higher dependency rates than Participants aged <75 years with SAO in all three follow-up periods, in addition to a higher recurrence rate at 12 months and a higher mortality rate 36 months after stroke. After adjusting for confounders, elevated triglyceride level was found to be a protective factor against mortality 36 months after stroke. Stroke severity, diabetes mellitus, artery stenosis, gender, obesity, and high-density lipoprotein cholesterol level were independently associated with the risk of dependency; elevated triglyceride level was an independent risk factor for recurrence at 3 months point after stroke onset. These findings suggest that it is vital to manage risk factors that may affect prognosis of stroke among elderly patients with SAO to improve patient prognosis and reduce the burden of stroke in China.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Prognosis and Associated Factors among Elderly Patients with Small Artery Occlusion

Zhao

Yang

Yan

et al. 2019

Sci Rep

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“…This study used data from a stroke registry in the Department of Neurology, Jiamusi University First Hospital, China; the inclusion criteria for stroke patients have been described in a previous study [ 37 ]. Briefly, we prospectively collected data on the clinical characteristics and outcomes for all ischemic stroke patients who were admitted to the department between January 2008 and December 2013.…”

Section: Methodsmentioning

confidence: 99%

Sex differences in outcomes and risk factors among elderly patients with ischemic stroke

et al. 2017

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We aimed to investigate the sex differences in the clinical characteristics and risk factors for adverse outcomes among elderly patients with atherosclerotic stroke. We recruited 942 consecutive patients with atherosclerotic stroke aged 75 years and older between January 2008 and December 2013 from Jiamusi University First Hospital, China. Stroke subtype, severity, risk factors, and outcomes (mortality, dependency, and recurrence) at 3 and 12 months after stroke were recorded and assessed. Mortality at 3 months after stroke was higher in men than in women. Stroke severity was an independent risk factor for mortality, dependency, and recurrence at 3 and 12 months after stroke in both men and women. However, the presence of total anterior circulation infarct and obesity protected against mortality at 3 months after stroke in men, while total anterior circulation infarct was a risk factor for dependency at 3 months after stroke in women. In women, positive associations were found between fasting plasma glucose level and mortality at 3 months after stroke and between hypertension, atrial fibrillation, and recurrence at 12 months after stroke. These findings suggest that it is crucial to control the primary risk factors individually by sex, especially regarding hypertension and atrial fibrillation management, to improve secondary prevention of stroke among the elderly and reduce the burden of stroke in China.

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“…This study used data from a stroke registry in the Department of Neurology, Jiamusi University First Hospital, China; the inclusion criteria for stroke patients have been described in a previous study (Wu et al, 2015 ). Briefly, we prospectively collected data on the clinical characteristics and outcomes for all ischemic stroke patients who were admitted to the Department of Neurology, Jiamusi University First Hospital, China between January 2008 and December 2013.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Outcomes after Stroke in Elderly Patients with Atrial Fibrillation: A Hospital-Based Follow-Up Study in China

Zhao

Zou

Wang

et al. 2016

Front. Aging Neurosci.

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Background: Atrial fibrillation (AF) significantly increases the risk of stroke and disease burden; it is an established predictor of poor outcomes after stroke. However, reported differences in outcomes after stroke among elderly patients between AF and non-AF group are conflicting. We aimed to compare differences in outcomes at 1 year and 3 years after stroke among elderly patients (aged ≥ 75 years old) between AF group and non-AF group.Methods: We recruited 1070 consecutive elderly patients who experienced acute ischemic stroke between January 2008 and December 2013 in Jiamusi University First Hospital, China in this study. Information regarding stroke subtype, severity, risk factors, and outcome (mortality, dependency, and recurrence) at 3 and 12 months after stroke were recorded and assessed between AF group and non-AF group.Results: The prevalence of AF was 16.1% overall, with a similar trend in the prevalence of AF between men and women. The AF group were more likely to experience severe stroke compared to the non-AF group (32.0 vs. 11.9%, respectively; P < 0.001). There were no obvious differences between groups regarding the prevalence of hypertension, dyslipidemia, obesity, current smoking, and alcohol drinking but there was a higher prevalence of diabetes in the non-AF group (20.3 vs. 30.1%, P = 0.010). Mortality and dependency rates were significantly higher in the AF group than in the non-AF group at 1 year after stroke (29.6 vs. 17.8%, P = 0.001 for mortality; and 59.5 vs. 36.1%, P = 0.010 for dependency) and 3 years after stroke (46.1 vs. 33.2%, P = 0.032 for mortality; and 70.7 vs. 49.2%, P = 0.010 for dependency); however, there was no significant between-groups differences in rates of recurrence across the follow-up periods. The results for dependency remained stable after adjustment for sex, stroke severity, and stroke risk factors at 3 years after stroke (OR, 2.26; 95% CI, 1.06–4.81; P = 0.034); however, the relationship between AF and mortality and recurrence disappeared after adjusting for these covariatesConclusion: These findings suggest that it is crucial to highlight the treatment of elderly stroke patients with AF in order to reduce poor outcomes among the elderly and to reduce the burden of AF in China.

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Risk factors of outcomes in elderly patients with acute ischemic stroke in China

Abstract: Stroke subtype and severity were associated with stroke outcomes among elderly patients in northern China. These findings suggest that it is crucial to highlight the affected factors of stroke outcome among elderly patients for reduce the burden of stroke in China.

Cited by 10 publications

References 33 publications

Prognosis and Associated Factors among Elderly Patients with Small Artery Occlusion

Prognosis and Associated Factors among Elderly Patients with Small Artery Occlusion

Sex differences in outcomes and risk factors among elderly patients with ischemic stroke

Long-Term Outcomes after Stroke in Elderly Patients with Atrial Fibrillation: A Hospital-Based Follow-Up Study in China

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