Risk factors of post renal transplant anaemia among Sudanese patients, a study in three renal transplant centres

Abstract

Background: There is a relative lack of recent information about late post kidney transplantation anaemia (PTA), especially in the developing countries; data are scarce about the prevalence and risk factors of PTA. Sudan was a leading country in Africa and Arab world in kidney transplantation. The first kidney transplantation in Sudan was in 1973.Methods: This is a cross-sectional hospital analytic study enrolling all kidney transplanted recipients following in the transplant referral clinics at Ahmed Gassim, Selma and Ibn Sina Hospitals, Khartoum/Sudan, in the period from 1/8/2010 to 1/9/2010, clinical and laboratory data were obtained from 114 patients, anaemia was defined as Hb levels of < 13 g/dl for male patients and < 12 g/dl for female patients, exclusion criteria were pregnancy, below 18 years old patients, multiple organ transplantation, and patients with less than one year from the transplantation.

The Prevalence and Risk Factors of Anemia in Children with Renal Transplant

“…Chronic allograft nephropathy can occur a long time after transplantation and that may lead to the development of PTA (27). In our study, low eGFR was found as a risk factor for PTA, at the 60 months of transplantation.…”

“…An American study reported this ratio as 26% within 5 years after transplant (23). The prevalence of late PTA was 39.5% (27) in another study. Most of these were adult studies.…”

“…So far, studies on the late PTA are not enough (1,7,13,23). Published data is limited on the prevalence of PTA; it varies in different studies (1,10,12,(25)(26)(27).…”

“…Rejection and renal dysfunction are associated with the development of PTA, which is considered as one of the major risk factors (1,3,23,(27)(28)(29)(30)(31)(32)(33). Chronic allograft nephropathy can occur a long time after transplantation and that may lead to the development of PTA (27).…”

Effect of renin‐angiotensin system inhibitors on survival in kidney transplant recipients: A systematic review and meta‐analysis

“…However, there is a lack of consensus on the direct effects of such treatment on patient and graft survival. On the one hand, some studies have confirmed that ACEI/ARB treatment can improve patient and graft survival [14–16], even without increasing the incidence of side effects like anaemia and hyperkalaemia [17,18]. On the other hand, some studies have indicated that ACEI/ARBs do not exert any beneficial effects on patient or graft survival [19,20].…”