Risk Factors of Rejection in Renal Transplant Recipients: A Narrative Review

Oweira, Hani; Ramouz, Ali; Ghamarnejad, Omid; Khajeh, Elias; Ali-Hasan-Al-Saegh, Sadeq; Nikbakhsh, Rajan; Reißfelder, Christoph; Rahbari, Nuh N.; Mehrabi, Arianeb; Sadeghi, Mahmoud

doi:10.3390/jcm11051392

Cited by 39 publications

(26 citation statements)

References 84 publications

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“…Inflammation crucially impacts allograft survival and acceptance. Oweira et al reported that macrophage inflammatory protein 2 and TNF-α are abnormally increased in a study on skin allograft rejection [29]. Zhu et al showed that the IGF-β application accelerates acute hepatic rejection [30].…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Improves the Survival and Angiogenesis of Fat Grafts after Autologous Fat Transplantation

Liu

Cui

et al. 2022

BioMed Research International

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Objective. Currently, autologous fat transplantation (AFT) still has a low graft survival rate. Elevation of the AFT graft survival rate is a challenge. This study investigated the effect of hyperbaric oxygen (HBO) on AFT. Methods. Twelve adult male SD rats were randomly divided into two groups after AFT: the control group ( n = 6 ) and the HBO group ( n = 6 ). The rats were killed at 7, 14, and 28 days after transplantation to take the transplanted adipose tissues. The volume and weight of the tissues were detected. The pathological changes in the adipose tissues were observed after H&E staining. Microvessel density and levels of transforming growth factor- (TGF-) β, tumor necrosis factor- (TNF-) α, and malondialdehyde (MDA) in the transplanted adipose tissues were measured with CD31 immunohistochemical stain, ELISA, and biochemical reagents, respectively. Additionally, the protein expression levels of vascular endothelial growth factor- (VEGF-) A and platelet-derived growth factor- (PDGF) A in the adipose tissues were detected by Western blot. Results. HBO significantly preserved the volume and weight of the transplanted adipose tissue ( p < 0.01 ) and maintained the pathological structure of the transplanted adipose tissue. HBO therapy was effective in reducing inflammatory factor (TGF-β and TNF-α) levels and oxidative stress (MDA) in the transplanted adipose tissue ( p < 0.01 ) and significantly increased the level of CD31 and angiogenesis-related factors including VEGF-A and PDGF-A ( p < 0.01 ) to promote angiogenesis. Conclusion. HBO therapy regulated the immune response of fat grafts, stimulated their angiogenesis, and ultimately promoted their survival after AFT.

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Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Improves the Survival and Angiogenesis of Fat Grafts after Autologous Fat Transplantation

Liu

Cui

et al. 2022

BioMed Research International

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“…A reduced nephron mass in RTRs may also increase their susceptibility to ischemic injury. Furthermore, renal allograft ischemia may exacerbate immune-related mechanisms of allograft injury, as manifested by the effect of cold and warm ischemia times on graft function and rejection ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Predictors and Adverse Outcomes of Acute Kidney Injury in Hospitalized Renal Transplant Recipients

Hod

Oberman²,

Scott

et al. 2023

Transpl Int

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Data about in-hospital AKI in RTRs is lacking. We conducted a retrospective study of 292 RTRs, with 807 hospital admissions, to reveal predictors and outcomes of AKI during admission. In-hospital AKI developed in 149 patients (51%). AKI in a previous admission was associated with a more than twofold increased risk of AKI in subsequent admissions (OR 2.13, p < 0.001). Other major significant predictors for in-hospital AKI included an infection as the major admission diagnosis (OR 2.93, p = 0.015), a medical history of hypertension (OR 1.91, p = 0.027), minimum systolic blood pressure (OR 0.98, p = 0.002), maximum tacrolimus trough level (OR 1.08, p = 0.005), hemoglobin level (OR 0.9, p = 0.016) and albumin level (OR 0.51, p = 0.025) during admission. Compared to admissions with no AKI, admissions with AKI were associated with longer length of stay (median time of 3.83 vs. 7.01 days, p < 0.001). In-hospital AKI was associated with higher rates of mortality during admission, almost doubled odds for rehospitalization within 90 days from discharge and increased the risk of overall mortality in multivariable mixed effect models. In-hospital AKI is common and is associated with poor short- and long-term outcomes. Strategies to prevent AKI during admission in RTRs should be implemented to reduce re-admission rates and improve patient survival.

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“…Ischemia after removal of an organ is a driving force in limiting the feasibility of organ transplantation (Oweira, Ramouz et al 2022). Moskowitzova et al (Moskowitzova, Shin et al 2019) hypothesized that mitochondrial transplantation may help increase the time between chilling an excised organ and having blood flow restored (cold ischemia time).…”

Section: Application Of Mitochondrial Transplantation In Cardiac Isch...mentioning

confidence: 99%

Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges

2022

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Risk Factors of Rejection in Renal Transplant Recipients: A Narrative Review

Cited by 39 publications

References 84 publications

Hyperbaric Oxygen Improves the Survival and Angiogenesis of Fat Grafts after Autologous Fat Transplantation

Hyperbaric Oxygen Improves the Survival and Angiogenesis of Fat Grafts after Autologous Fat Transplantation

Predictors and Adverse Outcomes of Acute Kidney Injury in Hospitalized Renal Transplant Recipients

Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges

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