Risk Factors of Retinopathy Among Diabetic’s Patients in Benin in 2014

Assavedo, C.R.A.

doi:10.24966/ocr-8887/100025

Cited by 5 publications

(8 citation statements)

References 14 publications

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“…In our study, 87.53% of the patients had at least one degenerative complication with retinopathy the most common degenerative disease (36.36%) followed by cardiovascular disease (25.45%). This figure is higher than what Razzouki [15] reported (33.84% retinopathy) and Assavedo (17.5%) in Parakou [16]. This frequency is similar to that reported by Djrolo [5] in Cotonou (36.6%).…”

Section: Discussionsupporting

confidence: 81%

Glycated Haemoglobin Determination in the Biological Follow-Up of Diabetic Subjects Admitted to the Endocrinology Department of the CNHU-HKM of Cotonou

Hodé¹,

Dedjan²,

Aboudou³

2023

JDM

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Introduction: One of the biological markers for monitoring glycaemic control in diabetic patients is glycated protein. The definition of a reference method to improve the accuracy of measurement tools is necessary. The aim of our study was to assess the glycemic control of diabetic patients based on glycated hemoglobin. Patients and Method: This is a descriptive cross-sectional study conducted in April 2021 at the national university hospital center (CNHU-HKM) of Cotonou. All patients who consulted during the period and who gave their consent were included. After collecting the blood samples according to the classical standards of the pre-analytical phase, we measured the blood glucose level and the HbA1c. Results: The mean blood glucose level of the patients was 1.52 ± 0.16 g/L with extremes of 0.80 g/L and 3.5 g/L. The mean HbA1c proportion was 8.39% ± 0.60% with a minimum and maximum value of 5.40% and 16% respectively. We also noted that the mean body mass index (BMI) of the patients was 28.61 ± 1.46 Kg/m 2 with extremes of 17.50 Kg/m 2 and 46.02 Kg/m 2 . Oral anti diabetic and hygienic-dietary measures were used by 44 patients (80%) and hygienic-dietary measures (HDM) only used by 9.09%. A frequency of 87.53% of patients had at least one degenerative complication. Retinopathy was the most observed degenerative disease (36.36%) followed by cardiovascular disease (25.45%). Conclusion: This study showed that there is a poor correlation between fasting blood glucose and glycated haemoglobin levels, which could be due to several biological and clinical reasons. It also showed that despite the respect of hygienic dietary measures and a well conducted treatment, it is difficult to obtain a satisfactory glycemic balance in obese patients. How to cite this paper: Kerekou Hode, A., Dedjan, H. and Aboudou, N. (2023) Glycated Haemoglobin Determination in the Biological Follow-Up of Diabetic Subjects Admitted to the Endocrinology Department of the CNHU-HKM of Cotonou.

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Section: Discussionsupporting

confidence: 81%

Glycated Haemoglobin Determination in the Biological Follow-Up of Diabetic Subjects Admitted to the Endocrinology Department of the CNHU-HKM of Cotonou

Hodé¹,

Dedjan²,

Aboudou³

2023

JDM

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“…In this study, we found strong evidence that both current value of FBS and rates of FBS change were associated with DR. Several earlier studies on type 2 DM patients showed that FBS level is significantly associated with DR 13 , 15 , 23 , 31 . But all these studies could not able to identify the effects of longitudinal FBS trajectory on the risk DR. By using joint modelling approach, we estimate the effects of longitudinal trajectory rate on the risk of DR.…”

Section: Discussionmentioning

confidence: 91%

“…Risk factors for DR among diabetes patients include sex, uncontrolled DM, longer duration of DM, presence of nephropathy and presence of hypertension, which have been documented in different studies 12 – 15 .…”

Section: Introductionmentioning

confidence: 96%

Joint modeling of time to diabetic retinopathy and change in fasting blood sugar among type 2 diabetic patients, Northwest Ethiopia

Kebede

Tessema

Balcha

et al. 2022

Sci Rep

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This study aimed to assess changes in fasting blood sugar (FBS) levels, time to diabetic retinopathy (DR) and its predictors among type 2 diabetes patients in Ethiopia. An institution-based retrospective follow-up study was conducted at the University of Gondar Comprehensive Specialized Hospital. The linear mixed effect model and Cox proportional hazard models were fitted separately, and later, the two models were fitted jointly using R software. Variables with a p value < 0.05 were considered significant predictors in the adjusted analysis. The incidence rate of DR was 2 per 100-person year of observation with a median follow-up time of 90.8 months (IQR 63.4). The current value and rate of change in FBS level were significant predictors of time to DR (AHR = 1.35; 95% CI 1.12–1.63) and (AHR = 1.70; 95% CI 1.21–2.39), respectively. Hypertension (AHR = 2.49; 95% CI 1.32–4.66), taking > 1 antidiabetic oral agent (AHR = 4.90; 95% CI 1.07–20.0) and more than 10 years duration (AHR = 0.17, 95% CI 0.06–0.46) were predictors of time to DR. This study revealed that the current value of FBS and the rate of FBS change were significantly associated with the time to DR.

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“…In this study, we observe strong evidence that both current value of FBS and rates of FBS change were associated with diabetic retinopathy. Several earlier studies on type 2 DM patients showed that fasting blood sugar level is significantly associated with diabetic retinopathy (14,16,26,33). But all these studies could not able to identify the effects of longitudinal FBS trajectory on the risk diabetic retinopathy.…”

Section: Discussionmentioning

confidence: 96%

“…Risk factors for diabetic retinopathy among diabetes patients includes gender, uncontrolled DM, longer duration of DM, presence of nephropathy and presence of hypertension were documented in different studies (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Joint Modeling of Time to Diabetic Retinopathy and Change in Fasting Blood Sugar Among Type 2 Diabetic Patients in University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Kebede

Tessema

Balcha

et al. 2021

Preprint

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Background: Early identification of prognostic factors and close monitoring of the biomarkers is used to monitor the occurrence or progression of diabetic retinopathy. Therefore, this study aimed to assess change in fasting blood sugar level, time to diabetic retinopathy and its predictors among type 2 diabetes patients in Ethiopia.Methods: Institution based retrospective follow-up study was conducted at University of Gondar Comprehensive Specialized Hospital. Linear mixed effect model and cox proportional hazard models were fitted separately and later the two models were fitted jointly using R software. Variables with p-value <0.05 were considered as significant predictors in the adjusted analysis.Result: The incidence rate of diabetic retinopathy was 2 per 100-person year of observation with median follow up time of 90.8 months (IQR: 63.4). The current value and rate of change in fasting blood sugar level were significant predictors of time to diabetic retinopathy (AHR=1.35;95% CI: 1.12-1.63) and (AHR=1.70; 95%CI:1.21-2.39) respectively. Hypertension (AHR=2.49; 95%CI: 1.32-4.66), taking >1 antidiabetic oral agent (AHR=4.90; 95%CI: 1.07-20.0) and more than 10 years duration (AHR=0.17, 95% CI: 0.06-0.46) were predictors of time to diabetic retinopathy.Conclusion: This study revealed that medication, duration, weight, current age, and time have significant association with the progression change of fasting blood sugar. On the other hand, hypertension, medication and duration were significant predictors of time to diabetic retinopathy. The current value of fasting blood sugar and rate of fasting blood sugar change were significantly associated with time to diabetic retinopathy.

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Risk Factors of Retinopathy Among Diabetic’s Patients in Benin in 2014

Cited by 5 publications

References 14 publications

Glycated Haemoglobin Determination in the Biological Follow-Up of Diabetic Subjects Admitted to the Endocrinology Department of the CNHU-HKM of Cotonou

Glycated Haemoglobin Determination in the Biological Follow-Up of Diabetic Subjects Admitted to the Endocrinology Department of the CNHU-HKM of Cotonou

Joint modeling of time to diabetic retinopathy and change in fasting blood sugar among type 2 diabetic patients, Northwest Ethiopia

Joint Modeling of Time to Diabetic Retinopathy and Change in Fasting Blood Sugar Among Type 2 Diabetic Patients in University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

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