2022
DOI: 10.1097/pec.0000000000002758
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Risk Factors of Serious Bacterial Infection in Previously Healthy Children Older Than 90 Days Old With Fever and Neutropenia

Abstract: Background:The main objective was to determine the clinical or analytical factors that independently predict risk of serious bacterial infection (RSBI) in immunocompetent patients older than 90 days given a diagnosis of fever and for whom neutropenia was an incidental finding. The secondary objective was to describe the prevalence of serious bacterial infections (SBIs).Methods: This is a 3-year-long, multicenter, prospective analytical and observational study carried out at 6 pediatric emergency departments. D… Show more

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“…Some of these children are neutropenic. SBI during febrile neutropenia (FN) is a medical emergency associated with significant morbidity and mortality if left untreated [3,4]. One-third of neutropenic episodes in paediatric patients on cancer treatment or during haematopoietic stem cell transplant (HSCT) are associated with fever [5].…”
Section: Introductionmentioning
confidence: 99%
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“…Some of these children are neutropenic. SBI during febrile neutropenia (FN) is a medical emergency associated with significant morbidity and mortality if left untreated [3,4]. One-third of neutropenic episodes in paediatric patients on cancer treatment or during haematopoietic stem cell transplant (HSCT) are associated with fever [5].…”
Section: Introductionmentioning
confidence: 99%
“…Differentiating viral, bacterial, and inflammatory illnesses on admission is challenging in HR patients: clinical syndromes are often non-specific, and at least 36-48 h is needed to culture microorganisms [4,6]. Because the risk of having SBI is significant [4,7], immunocompromised patients with febrile illness are virtually always admitted for intravenous antibiotic treatment, awaiting microbiological results, yet only around 20% will have a microbiologically documented infection [3,[8][9][10]. 41.3-62.3% will have no cause identified [11][12][13][14].…”
Section: Introductionmentioning
confidence: 99%