Risk factors of systematic biliary complications in patients with gallbladder stones

Cao, Zhe; Wei, Jinghua; Zhang, Ning; Liu, Wei; Hong, Tao; He, Xiaodong; Qu, Qiang

doi:10.1007/s11845-019-02161-x

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…Previous large cohort studies have reported that individuals in the general population with asymptomatic gallstones have a lifetime risk of developing complications ranging from 7 to 26%, with serious complications occurring at 1–2% annually 1 – 5 . Multiple stones, gallbladder polyps, large stones of >9 mm, and sludge were associated with an increased risk of developing complicated gallstone disease 29 , 30 . A small cohort study revealed that 15% patients who underwent KT developed gallstone complications requiring surgery 16 .…”

Section: Discussionmentioning

confidence: 95%

Silent gallbladder stone in kidney transplantation recipients: should it be treated? A retrospective cohort study

Lee,

Jang,

Kang

et al. 2024

International Journal of Surgery

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Background: Treatment and follow-up strategies for silent gallbladder stones in patients before kidney transplantation (KT) remain unknown. Therefore, we aimed to elucidate the role of pre-KT cholecystectomy in preventing biliary and surgical complications. Materials and Methods This study retrospectively analyzed 2,295 KT recipients and 3,443 patients waiting for KT at a single tertiary center from January 2005 to July 2022. The primary outcomes were the incidences of biliary and post-cholecystectomy complications in KT recipients. Firth’s logistic regression model was used to assess the risk factors for biliary complications. Results Overall, 543 patients awaiting KT and 230 KT recipients were found to have biliary stones. Among the KT recipients, 16 (7%) underwent cholecystectomy before KT, while others chose to observe their biliary stones. Pre-KT cholecystectomy patients did not experience any biliary complications, and 20 (9.3%) patients who chose to observe their stones experienced complications. Those who underwent cholecystectomy before KT developed fewer post-cholecystectomy complications (6.3%) compared with those who underwent cholecystectomy after KT (38.8%, P=0.042), including reduced occurrences of fatal postoperative complications based on the Clavien–Dindo classification. Multiple stones (odds ratio [OR], 3.09; 95% confidence interval [CI], 1.07–8.90; P=0.036), thickening of the gallbladder wall (OR, 5.39; 95% CI, 1.65–17.63; P=0.005), and gallstones>1 cm in size (OR 5.12, 95% CI: 1.92–13.69, P=0.001) were independent risk factors for biliary complications. Among patients awaiting KT, 23 (4.2%) underwent cholecystectomy during the follow-up, resulting in one post-cholecystectomy complication. Conclusion Gallstone-related biliary complications following KT and subsequent cholecystectomy was associated with more serious complications and worse treatment outcomes. Therefore, when KT candidates had risk factor for biliary complications, preemptive cholecystectomy for asymptomatic cholecystolithiasis could be considered to reduce further surgical risk.

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Section: Discussionmentioning

confidence: 95%

Silent gallbladder stone in kidney transplantation recipients: should it be treated? A retrospective cohort study

Lee,

Jang,

Kang

et al. 2024

International Journal of Surgery

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“…Cao et al [10] analyzed the complications of the patients with gallstones, reporting that 39.1% of the patients had diabetes, while 35.2% had hypertension, and that their cholesterol average was 188.32 ± 38.66 mg/dl. As far as our study is concerned, the underlying comorbid diseases of the subjects were established as diabetes (23.9%) and hypertension (6.5%), and the mean blood cholesterol level was calculated as 141.14 mg/dl (± 31.33).…”

Section: Discussionmentioning

confidence: 99%

Does the Frequency of Acute Cholecystitis Decrease During the Ramadan Month?

Seyit

Yılmaz

et al. 2021

International Journal of Health Services Research and Policy

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The pathophysiological mechanism of acute cholecystitis (AC), which is essentially the inflammation of the gallbladder, is blockage of the cystic duct, and its most common cause is gallstones. On the other hand, fasting held in Ramadan is worship practiced by Muslims within the period from dawn to sunset by avoiding any eating and drinking act. Within this framework, our study ultimately intends to reveal the variation of AC in two different time periods. We retrospectively compared the demographic characteristics, admittance times, biochemical parameters of the subjects diagnosed with AC and hospitalized in the general surgery between 2012 and 2018. We also evaluated diagnosis classification, length of hospitalization, presence of intensive care stay, presence of operation during hospitalization, and the underlying comorbid diseases of the subjects. 225 patients were hospitalized in the general surgery service after being diagnosed with AC in the ED over the course of six years, yet the total number of subjects recruited for the study is 46. Whereas 10 patients (21.7%) were admitted and hospitalized during the Ramadan month, 36 (78.3%) patients in the other group were hospitalized one month before and after Ramadan. 16 (34.8%) of the hospitalized patients underwent emergency surgery, while 30 (65.2%) patients were operated on electively. The comparison of the two cohorts in our study revealed no significant difference in relation to the demographic characteristics, laboratory findings, imaging methods, underlying comorbid diseases, and the length of hospital stay. Nevertheless, clinical investigations seem to have revealed a difference between groups.

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“…Construction of atherosclerosis plaques is boosted in diabetic patients and patients with lower level of HDL in blood. This procedure may be an important role in CVD and GSD [39][40][41].…”

Section: Comorbidities and Risk Factorsmentioning

confidence: 99%

“…Thus, causing stone formation on gallbladder. HDL and LDL-cholesterol level is associated with type 2 diabetes [38,[41][42][43].…”

Section: Comorbidities and Risk Factorsmentioning

confidence: 99%

Diabetes and Cholecystectomy: Is There a Relation?

Olangian-Tehrani

2023

JCSR

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The association between diabetes and cholecystectomy is debatable, as diabetes or cholecystectomy may be risk factors for each other. In this review, we look at the incidence rate, mechanisms, and complications of cholecystectomy in diabetic individuals and healthy ones and we also compare cholecystectomy in both to see whether diabetes is a risk factor for cholecystectomy or diabetes might lead to cholecystectomy, or both are contributed.

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Risk factors of systematic biliary complications in patients with gallbladder stones

Cited by 3 publications

References 22 publications

Silent gallbladder stone in kidney transplantation recipients: should it be treated? A retrospective cohort study

Silent gallbladder stone in kidney transplantation recipients: should it be treated? A retrospective cohort study

Does the Frequency of Acute Cholecystitis Decrease During the Ramadan Month?

Diabetes and Cholecystectomy: Is There a Relation?

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