Risk Factors of Venous Thromboembolism in Sudanese Pregnant Women

Abdalhabib, Ezeldine K; Alfeel, Aymen; Ali, EI; Ibrahim, I. K. A.; Mobarki, AA; Dobie, Gasim; Hamali, HA; Saboor, Muhammed

doi:10.2478/bjmg-2021-0018

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Pregnancy-related venous thromboembolism. We found two studies that examined the impact of contraceptive use on the risk of venous thromboembolism (VTE) during pregnancy compared to non-users [29,30]. The results indicated that there was a 94% higher risk of VTE among contraceptive users (95% CI 1.49, 2.52).…”

Section: Maternal Morbiditymentioning

confidence: 99%

A meta-analysis into the mediatory effects of family planning utilization on complications of pregnancy in women of reproductive age

Jahanfar,

Maurer,

Lapidow

et al. 2024

PLoS ONE

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Background Despite conflicting findings in the current literature regarding the correlation between contraceptives and maternal health consequences, statistical analyses indicate that family planning may decrease the occurrence of such outcomes. Consequently, it is crucial to assess the capability of family planning to mitigate adverse maternal health outcomes. Objectives This review investigates the effects of modern contraceptive use on maternal health. Search methods This systematic review is registered on Prospero (CRD42022332783). We searched numerous databases with an upper date limit of February 2022 and no geographical boundaries. Selection criteria We included observational studies, including cross-sectional, cohort, case-control studies, and non-RCT with a comparison group. We excluded systematic reviews, scoping reviews, narrative reviews, and meta-analyses from the body of this review. Main results The review included nineteen studies, with five studies reporting a reduction in maternal mortality linked to increased access to family planning resources and contraceptive use. Another three studies examined the impact of contraception on the risk of preeclampsia and our analysis found that preeclampsia risk was lower by approximately 6% among contraceptive users (95% CI 0.82–1.13) compared to non-users. Two studies assessed the effect of hormonal contraceptives on postpartum glucose tolerance and found that low-androgen contraception was associated with a reduced risk of gestational diabetes (OR 0.84, 95% CI 0.58–1.22), while DMPA injection was possibly linked to a higher risk of falling glucose status postpartum (OR 1.42, 95% CI 0.85–2.36). Two studies evaluated high-risk pregnancies and births in contraceptive users versus non-users, with the risk ratio being 30% lower among contraceptive users of any form (95% CI 0.61, 0.80). None of these results were statistically significant except the latter. In terms of adverse maternal health outcomes, certain contraceptives were found to be associated with ectopic pregnancy and pregnancy-related venous thromboembolism through additional analysis.

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Section: Maternal Morbiditymentioning

confidence: 99%

A meta-analysis into the mediatory effects of family planning utilization on complications of pregnancy in women of reproductive age

Jahanfar,

Maurer,

Lapidow

et al. 2024

PLoS ONE

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“…Numerous investigations have posited that a reduction in the concentrations of AT, PC, and PS may contribute to an augmented predisposition to DVT [9]. Hence, the assessment of these coagulation inhibitor levels among gravid females employing oral contraceptives can impart valuable perspicacity into the hazard of DVT within this cohort.…”

Section: Introductionmentioning

confidence: 99%

Protein C and protein S deficiencies are associated with increased risk of deep vein thrombosis in pregnant women using oral contraceptives

Elfaki,

Algarni,

Yousif

et al. 2023

Blood Coagulation &Amp; Fibrinolysis

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Background Oral contraceptives are commonly taken by women and are known to increase the risk of venous thromboembolism (VTE). Objective The aim of this study was to investigate the association between oral contraceptive use and natural anticoagulants, that is, protein C (PC), protein S (PS), and antithrombin in pregnant women with deep vein thrombosis (DVT). Materials and methods This case–control study was conducted on 330 pregnant women, that is, cases 165 (who used oral contraceptives) and controls 165 (who did not use oral contraceptives). The levels of PC, PS, and antithrombin were measured and compared between the two groups. The use of different types of oral contraceptives and their association with DVT and PC and PS were also analyzed. Results The study found that women with DVT had significantly lower levels of PC and PS compared with controls (P < 0.001). However, no significant difference was found in the levels of AT. Among the different types of oral contraceptives, first-generation progestin pills including Ethynodiol Diacetate, Norethindrone Acetate, Norethynodrel, and second-generation oral contraceptives (Lynestrenol, Levonorgestrel and Norgestrel) were not found to be associated with lower levels of PC and AT while Desogestrel, Norgestimate, and Gestodene (third-generation) were associated with lower levels of PS. Conclusion This study suggests that the use of contraceptives, particularly those containing Desogestrel, Norgestimate, and Gestodene, may be associated with a higher risk of thrombosis because of the associated lower levels of PS. Monitoring anticoagulant levels is crucial in preventing DVT in this population.

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Epidemiology and prognostic factors for new-onset deep venous thrombosis after unicompartmental knee arthroplasty: a retrospective study

Li,

Zhang,

et al. 2024

BMC Musculoskelet Disord

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Background Patients who underwent knee joint arthroplasty were at risk of venous thromboembolic events (VTEs), however, less studies were conducted to demonstrate the epidemiology and risk factors of deep venous thrombosis (DVT) following unicompartmental knee arthroplasty (UKA). Objective of this study was to explore the incidence and prognostic factors of DVT after UKA. Methods Patients who underwent primary UKA from December 2018 to June 2022 were recruited in this study. Demographic characteristics, operation related variables and laboratory index were extracted and analyzed. Receiver operating characteristic analysis was performed to detect the optimum cut-off value for variables of interest. Univariate and multivariate logistic analysis were performed to identify risk factors of DVT. Results 351 UKAs with a mean age of 65.4 ± 7.1 years were reviewed. After 12.9 ± 11.2 months follow-up, 35 DVTs were confirmed which indicating an incidence of 9.9%. The results showed that occupation (agricultural laborer) (P = 0.008), disease duration > 8.5 years (P = 0.035), operation time > 169 min (P = 0.003), intraoperative blood loss > 102 ml (P < 0.001), BMI > 26.8 kg/m 2 (P = 0.001), preoperative D-dimer > 0.29 mg/L (P = 0.001), prothrombin time < 10.7 s (P = 0.033) and INR < 0.98 (P = 0.032) between DVT and Non-DVT group were significantly different. Multivariate logistic regression analysis showed intraoperative blood loss > 102 ml (OR, 3.707; P, 0.001), BMI > 26.8 kg/m 2 (OR, 4.664; P, 0.004) and D-dimer > 0.29 mg/L (OR, 2.882; P, 0.009) were independent risk factors of DVT after UKA. Conclusion The incidence of DVT in the present study was 9.9%, extensive intraoperative blood loss, advanced BMI and high level of D-dimer would increase the risk of lower extremity thrombosis by 2–4 times.

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Risk Factors of Venous Thromboembolism in Sudanese Pregnant Women

Cited by 3 publications

References 24 publications

A meta-analysis into the mediatory effects of family planning utilization on complications of pregnancy in women of reproductive age

A meta-analysis into the mediatory effects of family planning utilization on complications of pregnancy in women of reproductive age

Protein C and protein S deficiencies are associated with increased risk of deep vein thrombosis in pregnant women using oral contraceptives

Epidemiology and prognostic factors for new-onset deep venous thrombosis after unicompartmental knee arthroplasty: a retrospective study

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