2022
DOI: 10.1007/s40618-022-01769-8
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Risk factors on testicular function in adolescents

Abstract: Purpose Adolescence represents an important window for gonadal development. The aim of this review is to carry out a critical excursus of the most recent literature on endogenous and exogenous risk factors related to testicular function, focusing the research on adolescence period. Methods A comprehensive literature search within PubMed was performed to provide a summary of currently available evidence regarding the impact on adolescence of varicocele, cry… Show more

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Cited by 9 publications
(2 citation statements)
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“…Although the introduction of HAART has reduced the incidence of hypogonadism among HIV-infected men, it is still considered the most common endocrine dysfunction, with a prevalence of up to 30% ( 11 , 92 ). Moreover, this condition is increasingly affecting even adolescents, representing a potential problem for the proper development of testicular function ( 93 ).…”
Section: Hiv/aidsmentioning
confidence: 99%
“…Although the introduction of HAART has reduced the incidence of hypogonadism among HIV-infected men, it is still considered the most common endocrine dysfunction, with a prevalence of up to 30% ( 11 , 92 ). Moreover, this condition is increasingly affecting even adolescents, representing a potential problem for the proper development of testicular function ( 93 ).…”
Section: Hiv/aidsmentioning
confidence: 99%
“…The direct effects of obesity on the reproductive organs are not fully understood, are complex, and may negatively impact male fertility by several mechanisms, which include increased oxidative stress, altered scrotal temperature related to adipose tissue distribution, and imbalance in the testosterone/ estrogen ratio, increased levels of inflammatory mediators, DNA fragmentation, and epigenetic changes in the spermatozoon, which culminate in damage to spermatogenesis, spermiogenesis, and sperm maturation, and therefore sperm quality (Figure 2) (CHAMBERS & ANDERSON, 2015;LEISEGANG et al, 2021;CARGNELUTTI et al, 2022).…”
Section: Obesity and Male Reproductionmentioning
confidence: 99%