Risk factors, patterns and outcomes of late recurrence after liver resection for patients with hepatocellular carcinoma: analysis of a multicenter cohort over 15 years

Abstract

frozen plasma transfusion, and graft implantation time, leading to 0e25 score points with an AUC of 0.7 in the new AKI-Predict-Score (Fig. 1). Three risk classes were identified: low-risk (0e10 points), intermediate-risk (11e20 points) and high-risk with >20 points. In addition, a score of >20 points correlated with impaired long-term graft survival and more postoperative complications assessed with the Comprehensive Complication Index. Conclusion:The AKI-Predict-Score is a new and reliable instrument to identify recipients at risk for severe post-transplant AKI. This score is readily available at end of the transplant procedure. This model offers therefore a great potential to decide which renal protective strategies might be implemented directly after liver transplant.

Care After Liver Resection for Hepatocellular Carcinoma

“…Alain Braillon, MD, PhD Jean-Marc Regimbeau, MD, PhD To the Editor With great interest, we read the article by Xu et al 1 The authors investigated the risk factors, patterns, and predictors of long-term outcomes in 734 patients with and without late hepatocellular carcinoma (HCC) recurrence after curative resection.…”

“…Keita Okubo, MD, PhD Amika Moro, MD Kazunari Sasaki, MD In Reply We thank Braillon and Regimbeau for their interest in our 2018 publication titled "Risk Factors, Patterns, and Outcomes of Late Recurrence After Liver Resection for Hepatocellular Carcinoma: A Multicenter Study From China." 1 As Braillon and Regimbeau highlighted in their letter, smoking may be an important contributing factor for the development of hepatocellular carcinoma (HCC). We agree with this point, but we believe that smoking should not be considered as the main cause for HCC development, which did not contribute much to the occurrence of late recurrence after curative resection for HCC.…”

“…Poorly justified follow-up tests add time burden for patients, anticipatory anxiety while waiting for results, and cost and increase radiation exposure. 1 We read with interest the article by Xu et al, 2 which provides important information for guiding follow-up of patients after resection of hepatocellular carcinoma. This large multicenter study documents a clear shift in recurrence patterns after 2 years of followup.…”

“…In fact, these data would encourage a trial of sonography alone vs much more complex follow-up regimens. 1 Having 90% of recurrences occur in the liver also implies that transplant is a sensible salvage option. The likelihood of additional extrahepatic disease is low.…”

Care After Liver Resection for Hepatocellular Carcinoma

“…Poorly justified follow-up tests add time burden for patients, anticipatory anxiety while waiting for results, and cost and increase radiation exposure. 1 We read with interest the article by Xu et al, 2 which provides important information for guiding follow-up of patients after resection of hepatocellular carcinoma. This large multicenter study documents a clear shift in recurrence patterns after 2 years of followup.…”