Risk factors predicting recurrence of transient global amnesia

Oliveira, Renato; Teodoro, Tomás; Marques, Inês Brás

doi:10.1007/s10072-020-04788-6

Cited by 19 publications

(33 citation statements)

References 13 publications

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“…The recurrence rate of our study is very consistent with the rate of 13.5% ascertained from a recent review from nine different cohort studies involving 1,989 patients (4). An overview of studies on recurrence rates in TGA is displayed in Table 2 (6)(7)(8)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). The recurrence rates varied between these studies, which might be explained by the diagnostic accuracy of the patients investigated.…”

Section: Discussionsupporting

confidence: 87%

“…For example, a disclosure of a TIA as a potential alternative diagnosis was not guaranteed in all cases ( 17 ). Furthermore, the duration of the follow-up period ranged widely from 16.5 months ( 7 ) to 15.0 years ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

“…Oliveira et al reported more punctate hippocampal hyperintensities in patients with recurrent TGA ( n = 5) versus single TGA ( N = 0) in a total of 34 patients with available MRI data ( p = 0.001) ( 7 ). In our study, there was no difference between patients with versus without subsequent recurrence in the presence and number (unilateral vs. bilateral) of hippocampal DWI lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Typically, TGA occurs as a single event, but recurrences are occasionally described with up to 11 TGA episodes anecdotally reported in one patient ( 5 ). A recent systematic review, evaluating nine cohort studies with a total of 1,989 patients, reported an overall recurrence rate of 13.5% ( 4 ), although single studies showed a wide variation (from 5.4 to 27.1%) ( 6 , 7 ). Interestingly, patients with TGA recurrence were found to be younger ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

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Transient Global Amnesia (TGA): Younger Age and Absence of Cerebral Microangiopathy Are Potentially Predisposing Factors for TGA Recurrence

et al. 2021

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Background: Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear etiology for a period of less than 24 h. TGA occurs as a single event in most cases. Prevalence rates of recurrent TGA vary widely from 5.4 to 27.1%. This retrospective study aimed to determine predictors for TGA recurrence.Methods: Cardiovascular risk profile and magnetic resonance imaging (MRI) of 340 hospitalized TGA patients between 2011 and 2020 were retrospectively analyzed. The median follow-up period amounted to 4.5 ± 2.7 years. Comparisons were made between TGA patients with and without subsequent recurrence.Results: TGA patients with subsequent recurrence were significantly younger (recurrent vs. single episode, 63.6 ± 8.6 years vs. 67.3 ± 10.5 years, p = 0.032) and showed a lower degree of cerebral microangiopathy compared to TGA patients without recurrence. The mean latency to recurrence was 3.0 years ± 2.1 years after the first episode. In a subgroup analysis, patients with at least five years of follow-up (N = 160, median follow-up period 7.0 ± 1.4 years) had a recurrence rate of 11.3%. A 24.5% risk of subsequent TGA recurrence in the following five years was determined for TGA patients up to 70 years of age without microangiopathic changes on MRI (Fazekas' score 0).Conclusion: Younger TGA patients without significant microangiopathy do have an increased recurrence risk. In turn, pre-existing cerebrovascular pathology, in the form of chronic hypertension and cerebral microangiopathy, seems to counteract TGA recurrence.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transient Global Amnesia (TGA): Younger Age and Absence of Cerebral Microangiopathy Are Potentially Predisposing Factors for TGA Recurrence

et al. 2021

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“…Additionally, patients with recurrent TGA events had a higher ALPS index than healthy controls. Sev-eral studies have investigated the risk factors for TGA recurrence and suggest that recurrence is associated with female, depression, short duration of amnesia, hippocampal dot lesion on DWI, early age of onset, and history of migraine and head injury [39][40][41]. However, to date, no studies have investigated the association between glymphatic system function and recurrence in patients with TGA.…”

Section: Discussionmentioning

confidence: 99%

Glymphatic System Function in Patients with Transient Global Amnesia

Lee¹,

Park²,

Park³

et al. 2022

J. Integr. Neurosci.

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Background:The purpose of this study was to examine glymphatic system function in patients with transient global amnesia (TGA), as well as to conduct a recurrence analysis. Methods: We enrolled patients with TGA and healthy controls from our hospital retrospectively. The patients and healthy controls were all scanned with the same 3T scanner, which included diffusion tensor imaging (DTI). We investigated the function of the glymphatic system using DTI analysis along the perivascular space (DTI-ALPS). The ALPS index was compared between patients with TGA and healthy controls, as well as between patients who had recurrent TGA events and those who had only a single TGA event. Results: Seventy-two patients with TGA and 53 healthy controls were enrolled. Sixty-five patients with TGA had a single TGA event, while seven patients had recurrent TGA events. The ALPS index did not differ significantly between patients with TGA and healthy controls (1.665 vs. 1.618, p = 0.436). The ALPS index, on the other hand, varied significantly according to recurrence in patients with TGA. The ALPS index was significantly higher in patients with recurrent TGA events compared to those with a single event (1.928 vs. 1.636, p = 0.049). Conclusions: We investigated the glymphatic system function in patients with TGA compared to healthy controls for the first time using the DTI-ALPS method. We discovered that these groups did not differ in terms of glymphatic system function. However, glymphatic system function in patients with TGA may differ according to recurrence. Additional research is required to substantiate these findings.

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Prognosis and Management of TGA

Larner

2022

Transient Global Amnesia

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Risk factors predicting recurrence of transient global amnesia

Cited by 19 publications

References 13 publications

Transient Global Amnesia (TGA): Younger Age and Absence of Cerebral Microangiopathy Are Potentially Predisposing Factors for TGA Recurrence

Transient Global Amnesia (TGA): Younger Age and Absence of Cerebral Microangiopathy Are Potentially Predisposing Factors for TGA Recurrence

Glymphatic System Function in Patients with Transient Global Amnesia

Prognosis and Management of TGA

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