2021
DOI: 10.3389/fendo.2021.672024
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Risk Factors, Prognostic Factors, and Nomograms for Distant Metastasis in Patients With Newly Diagnosed Osteosarcoma: A Population-Based Study

Abstract: BackgroundOsteosarcoma is the most common bone cancer, mainly occurring in children and adolescents, among which distant metastasis (DM) still leads to a poor prognosis. Although nomogram has recently been used in tumor areas, there are no studies focused on diagnostic and prognostic evaluation of DM in primary osteosarcoma patients.MethodsThe data of osteosarcoma patients diagnosed between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multiva… Show more

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Cited by 41 publications
(53 citation statements)
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“…Older persons had a higher proportion of lung metastases in PCLM patients regarding age at diagnosis. This finding was consistent with many studies, which show age as an independent risk factor for distant metastases ( 29 31 ). We suspected that it might be due to various changes that have taken place in the body's metabolism and development with age.…”
Section: Discussionsupporting
confidence: 93%
“…Older persons had a higher proportion of lung metastases in PCLM patients regarding age at diagnosis. This finding was consistent with many studies, which show age as an independent risk factor for distant metastases ( 29 31 ). We suspected that it might be due to various changes that have taken place in the body's metabolism and development with age.…”
Section: Discussionsupporting
confidence: 93%
“…Some attempts have been made to establish a metastasis predictive model; however, most of them merely focused on a single inflammatory factor or clinical feature, which is difficult to represent the disease state of those patients (28,(31)(32)(33). In this study, we also verified that the LIPI had an advantage over predicting the metastasis status over other single inflammation factors and clinical features (Figures 2A, 5).…”
Section: Discussionsupporting
confidence: 69%
“…Nomograms are rarely reported in predicting metastasis in osteosarcoma. Most of the nomograms are established by integrating clinical parameters and genes associated with metastasis (48)(49)(50)(51). However, due to the imprecision of clinical features and the clinical inapplicability of genes, the clinical application of these nomograms was limited.…”
Section: Discussionmentioning
confidence: 99%