Risk Genetic Variants (IL-10) for Osteoporosis in Han Population from Northwest China

Abstract

Background: Osteoporosis (OP) is a common metabolic bone disease characterized by loss of bone mass. IL-10 is considered to be a powerful immune and inflammatory suppressor. This study aimed to assess association between genetic loci in IL-10 and susceptibility to OP. Methods: Association analysis between IL-10 genetic loci and OP risk through SNPStats online software. FPRP analysis (falsepositive report probability) verified whether the positive results were noteworthy findings. Linkage disequilibrium (LD) and haplotype analysis were completed by Haploview 4.2 and SNPStats. Multi-factor dimensionality reduction (MDR) was used to assess interaction of SNP-SNP in susceptibility to OP.

Text Mining and Drug Discovery Analysis: A Comprehensive Approach to Investigate Diabetes-Induced Osteoporosis

“…However, its expression decreases in a high-glucose environment, leading to osteoblast proliferation disorder [16]. IL10, renowned for its potent immune and inflammatory suppression properties, is thought to inhibit bone resorption and reduce bone loss [17], but some studies have proved that IL10 is significantly increasing in DM patients [18,19], which also just goes to show that DOP development and its regulatory mechanisms are quite complex. Moving on to IL17A, a proinflammatory cytokine, it can indirectly stimulate bone resorption by RANKL (receptor activator of NF-κB ligand) [20,21].…”