Risk indicators associated with in-hospital mortality and severity in patients with diabetes mellitus and confirmed or clinically suspected COVID-19

Pazoki, Marzieh; Keykhaei, Mohammad; Kafan, Samira; Montazeri, Mahnaz; Hazaveh, Mojgan Mirabdolhagh; Sotoodehnia, Mehran; Kazemian, Sina; Talebpour, Mohammad; Ashraf, Haleh; Moharari, Reza Shariat; Majidi, Fazeleh; Amlashi, Nazanin Hedayati; Zare, Sara; Fathi, Mojtaba; Azimbeik, Zohre; Ebrahimi, Mehdi

doi:10.1007/s40200-020-00701-2

Cited by 27 publications

(19 citation statements)

References 39 publications

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“…46 So far, several studies have narrowed the path, linking DM with COVID-19 progression. 47,48 The significant association of DM with COVID-19 severity in our study is similar to the results of a pooled analysis, which demonstrated that patients with DM had significantly higher risks of disease severity and mortality. 47 Across sex disparity, Galbadage and colleagues 49 indicated male sex as an essential risk factor for COVID-19 progression.…”

Section: Discussionsupporting

confidence: 88%

Clinical significance of prognostic nutrition index in hospitalized patients with COVID‐19: Results from single‐center experience with systematic review and meta‐analysis

et al. 2021

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Background: We aimed to ascertain risk indicators of in-hospital mortality and severity as well as to provide a comprehensive systematic review and metaanalysis to investigate the prognostic significance of the prognostic nutrition index (PNI) as a predictor of adverse outcomes in hospitalized coronavirus disease 2019 (COVID-19) patients. Methods: In this cross-sectional study, we studied patients with COVID-19 who were referred to our hospital from February 16 to November 1, 2020. Patients with either a real-time reverse-transcriptase polymerase chain reaction test that was positive for COVID-19 or high clinical suspicion based on the World Health Organization (WHO) interim guidance were enrolled. A parallel systematic review/meta-analysis (in PubMed, Embase, and Web of Science) was performed. Results: A total of 504 hospitalized COVID-19 patients were included in this study, among which 101 (20.04%) patients died during hospitalization, and 372

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Section: Discussionsupporting

confidence: 88%

Clinical significance of prognostic nutrition index in hospitalized patients with COVID‐19: Results from single‐center experience with systematic review and meta‐analysis

et al. 2021

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“…After the full text of the articles was read, 119 were excluded due to irrelevance to the current meta-analysis scope, and/or were case reports, reviews, previous meta-analyses, and other disease or lack of the relevant data. Finally, a total of ten publication including 11,755 infected cases with 942 deaths were selected [14,[36][37][38][39][40][41][42][43][44]. The study characteristics of included studies in the present meta-analysis are described in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis

Mirjalili

Dastgheib

Shaker

et al. 2021

J Diabetes Metab Disord

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Background Currently, the number of patients with SARS-COV-2 infection has increased rapidly in Iran, but the risk and mortality of SARS-COV-2 infection in Iranian patients with diabetes mellitus (DM), chronic kidney disease (CKD), hypertension and cardiovascular diseases (CVDs) still not clear. The aim of this meta-analysis was to estimate the proportion and mortality of SARS-COV-2 in these patients. Methods A comprehensive literature search was carried out in PubMed, Web of Sciences, Cochrane Library, EMBASE, CNKI, SciELO, and other databases to identify all relevant studies published up to 10 January, 2020. The proportion and mortality in the patients were assessed by odd ratio (OR) and the corresponding 95 % confidence interval (95 % CI). Results A total of ten case-series including 11,755 cases with SARS-COV-2 infection and 942 deaths were selected. Among them, there were total of 791 DM patients with 186 deaths, 225 CKD patients with 45 deaths, 790 hypertension cases with 86 deaths, and 471 CVDs cases with 60 deaths. Pooled data revealed that the proportion of SARS-COV-2 infection in the patients with hypertension, DM, CVDs and CKD were 21.1 %, 16.3 %, 14.0 % and 5.0 %, respectively. Moreover, the SARS-COV-2 infection were associated with an increased risk of mortality in DM (OR = 0.549, CI 95 % 0.448-0.671, p ≤ 0.001) and CKD (OR = 0.552, 95 % CI 0.367-0.829, p = 0.004) patients, but not hypertension and CVDs. There was no publication bias. Conclusions Our pooled data showed that the proportion of SARS-COV-2 infection was the highest in the Iranian patients with hypertension (21.1 %) followed by DM (16.3 %), CVDs (14.0 %) and CKD (5.0 %). Moreover, DM and CKD in patients with SARS-COV-2 infection were associated with a 0.549 and 0.552-fold increase in mortality, respectively. Clinicians in Iran should be aware of these findings, to identifying patients at higher risk and inform interventions to reduce the risk of death. Moreover, well-designed, large-scale and multicenter studies are needed to improve and validate our findings.

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“…We evaluated electronic reports of 1413 patients admitted to Sina hospital, one of the major teaching hospitals for treating patients with COVID-19 in Tehran, Iran, between February 20 and October 29, 2020 as were partially included and defined in terms of treatment our primary reports [ 17 – 19 ]. The inclusion criteria for study participants were defined as patients with age ≥ 18-year-old who had been hospitalized in Sina hospital with the diagnosis of COVID-19 according to upcoming criteria.…”

Section: Methodsmentioning

confidence: 99%

“…In December 2019, new cases of atypical pneumonia were reported in Wuhan, China [1]. After detecting coronavirus disease-2019 (COVID- 19), which is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the World Health Organization (WHO) announced the pandemic on March 11th, 2020 [2]. It has been reported patients with diabetes mellitus (DM), compared to those without DM, are more likely to have a higher prevalence of hospitalization, severity and mortality of COVID-19, and DM has emerged as an important prognostic factor for severity and mortality in COVID-19 infection [3,4].…”

Section: Introductionmentioning

confidence: 99%

Association of clinical characteristics, antidiabetic and cardiovascular agents with diabetes mellitus and COVID-19: a 7-month follow-up cohort study

Pazoki

Chichagi

Hadadi

et al. 2021

J Diabetes Metab Disord

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Risk indicators associated with in-hospital mortality and severity in patients with diabetes mellitus and confirmed or clinically suspected COVID-19

Cited by 27 publications

References 39 publications

Clinical significance of prognostic nutrition index in hospitalized patients with COVID‐19: Results from single‐center experience with systematic review and meta‐analysis

Clinical significance of prognostic nutrition index in hospitalized patients with COVID‐19: Results from single‐center experience with systematic review and meta‐analysis

Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis

Association of clinical characteristics, antidiabetic and cardiovascular agents with diabetes mellitus and COVID-19: a 7-month follow-up cohort study

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