Risk management among benzene-exposed oil refinery workers

Tompa, Anna; Jakab, Mátyás G.; Major, Jenő

doi:10.1016/j.ijheh.2005.01.029

Cited by 30 publications

(24 citation statements)

References 20 publications

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“…14.2 DNA repair capacity in the exposure groups U V -i n d u c e d D N A r e p a i r c a p a c i t i e s ( U D S ) i n P B L s w e r e d e c r e a s e d , w h i l e C A y i e l d s (including the chromosome type aberrations) were increased in each groups exposed to aromatic hydrocarbons (benzene and PAHs) when compared to the controls in accordance with our earlier observations (Tompa et al 2005). Exposure to benzene, which was present in the ambient air could produce DNA strand breaks and oxidation of the bases in correlation with the level of its metabolite phenylmercapturic acid in urine (Sorensen et al 2003).…”

Section: Gene and Environmental Interactionssupporting

confidence: 90%

“…Studies of cigarette smokers, groups of workers exposed to various chemicals e.g. uranium, butadiene (Au et al, 1996), benzene, and cytostatic drugs (Tompa et al, 1994(Tompa et al, , 2005(Tompa et al, , 2006, suggest that exposed populations can have a mutagen-induced abnormal DNA repair response. Repair mechanisms involved in the development of malignancies suggest an important role of DNA repair studies in cancer risk assessment.…”

Section: The Use Of Uv-induced Dna Repair For Risk Assessmentmentioning

confidence: 99%

“…The measurement of UDS was done according to Bianchi et al(1982), as previously described (Tompa et al, 2005). Briefly, the separation of peripheral blood lymphocytes (PBLs) of citrated blood samples was performed by Ficoll-Hypaque density centrifugation.…”

Section: The Measurement Of Uv Induced Unscheduled Dna Synthesis (Udsmentioning

confidence: 99%

“…Ambient air PAH levels and their diol epoxide metabolites also correlate with DNA base oxidation and strand breaks in the exposed human populations (Ruchirawat et al 2010;Zhong et al 2010). However, several studies demonstrated reduction in DNA repair capacity (measured by different methods) among benzene or PAHs exposed workers (Tompa et al 2005;Keretetse et al 2008;Chanvaivit et al 2007;Ruchirawat et al 2010). Using the Comet assay for the characterization both of the level of primary DNA lesions and repair in PBLs of petrol attendants with occupational exposures longer than 1 year, Keretetse et al (2008) demonstrated that the genotoxic volatile organic compounds such as benzene and certain PAHs can inhibit the repair of single-strand breaks.…”

Section: Gene and Environmental Interactionsmentioning

confidence: 99%

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Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment

Tompa¹,

Major²,

Jakab³

2011

DNA Repair and Human Health

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Section: Gene and Environmental Interactionssupporting

confidence: 90%

Section: The Use Of Uv-induced Dna Repair For Risk Assessmentmentioning

confidence: 99%

Section: The Measurement Of Uv Induced Unscheduled Dna Synthesis (Udsmentioning

confidence: 99%

Section: Gene and Environmental Interactionsmentioning

confidence: 99%

See 2 more Smart Citations

Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment

Tompa¹,

Major²,

Jakab³

2011

DNA Repair and Human Health

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“…Vizsgálataink során olajipari dolgozók követésére volt lehetőség az 1989-2014 közötti 25 éves periódusban [11][12][13]. A vizsgálatok nem csupán a géntoxikológiai, hanem az immunstátusz változásait is követték a klinikai állapot és a laboratóriumi eredmények mellett.…”

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A nem alkoholos zsírmáj befolyásoló hatása olajipari munkások perifériás lymphocytáinak gén- és immuntoxikológai paramétereire

et al. 2016

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Bevezetés: A magyarországi felnőtt lakosság több mint fele túlsúlyos vagy elhízott, amelynek hátrányos következménye a zsírmáj kialakulása lehet. Az esetek 20-30%-ában nem alkoholos eredetű, hanem az elhízással, cukorbajjal vagy metabolikus szindrómával függhet össze. Célkitűzés: Jelen dolgozatban az olajipari munkások körében fellelhető, nem alkoholos zsírmáj eseteit hasonlították össze a kontrollokkal a gén-és immuntoxikológiai károsodások függvé-nyében. Módszer: 107 olajipari munkás adatait hasonlították össze 67 felnőtt férfi kontrollal. Eredmények: Az olaj ipari dolgozóknál az esetek 36%-ában volt jelen zsírmáj. A kontrollok csoportjában sem zsírmáj, sem géntoxikológiai elté-rés nem volt. Az exponáltak körében a citogenetikai paraméterek pozitivitása a kontrollhoz képest szignifikánsan emelkedett, amit a zsírmáj jelenléte tovább fokozott. Az immunológiai paraméterek közül a zsírmájban szenvedő exponáltaknál a CD71-pozitív, vagyis transzferrinreceptort hordozó B-sejtek aránya nőtt. Következtetések: A nem alkoholos zsírmáj az ipari vegyi expozícióval együtt képes a géntoxikus és az immuntoxikus hatások fokozására, amit a munkaalkalmasság megállapításában és a kockázatbecslésben a jövőben figyelembe kell venni. Orv. Hetil., 2016, 157(35), 1394-1402. Kulcsszavak: géntoxikológiai monitor, immuntoxikológia, kromoszóma, DNS-repair, zsírmáj, foglalkozás-egészség-ügy Influence of non-alcoholic fatty liver disease on geno-and immunotoxic alterations of peripheric blood lymphocytes of oil refinery workersIntroduction: More than half of the Hungarian population is overweight or obese, therefore, non-alcoholic fatty liver is a common problem. According to clinical experience, 20-30% of fatty liver cases is not related to alcohol, but can be linked to diabetes, obesity or metabolic syndrome. Aim: The authors studied the correlation between genotoxicity, immuntoxicity and non-alcoholic fatty liver among oil refinery workers. Method: During this genotoxicological monitoring study the data of 107 exposed were compared to 67 controls. Results: 36% of oil refinery workers had non-alcoholic fatty liver, while none of the selected, non-exposed controls had this abnormality. Chromosomal aberrations were elevated from 1.6% to 3.75% in the exposed group, immunotoxicological parameters were also changed, and CD71 positive B-cell ratio increased especially among subjects having non-alcoholic fatty liver. Conclusions: Non-alcoholic fatty liver can negatively influence the genotoxic effects of environmental hazards in workplaces.In the future this condition should be considered during risk assessment.

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Cytogenetic biomonitoring on a group of petroleum refinery workers

Basso

Cevoli

Papacchini³

et al. 2011

Environ and Mol Mutagen

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Workers employed in petroleum refineries are exposed to a wide range of toxic compounds (benzene, polycyclic aromatic hydrocarbons, heavy metals, etc.) with known mutagenic and carcinogenic potential. In this study, we investigated by using the cytokinesis block micronucleus (CBMN) assay on human peripheral blood lymphocytes (PBL) whether general occupational exposure in petroleum refineries resulted in early biological effects, which would be indicative of adverse health effects in the long term. In this study, out of more 500 workers enrolled in the study, 79 male subjects (46 nonsmokers and 33 smokers), employed in two different Italian petroleum refineries, and a total of 50 male control subjects (34 nonsmokers and 16 smokers) were selected by using very strict selection criteria. The comparison of chromosome damage in PBL between exposed and control populations pointed out a significant increase of micronuclei in the exposed group, correlated with the length of employment. Results confirm that smoking is the principal confounding factor for the responses. In conclusion, our results are indicative of a potential genotoxic risk related to the complex occupational exposure in petroleum refineries, despite the measures adopted in the plants, and corroborate the need to increase safety measures to avoid exposure to chemical agents.

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Risk management among benzene-exposed oil refinery workers

Cited by 30 publications

References 20 publications

Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment

Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment

A nem alkoholos zsírmáj befolyásoló hatása olajipari munkások perifériás lymphocytáinak gén- és immuntoxikológai paramétereire

Cytogenetic biomonitoring on a group of petroleum refinery workers

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