Risk Management Strategies for HIV in Blood Transfusion in Developing Countries

Bharucha, Z

doi:10.1111/j.1423-0410.2002.tb05294.x

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…All eligible patients were in good general health (except for condition for which surgery was scheduled), as evidenced by medical history, physical examination, clinical laboratory test and 12-lead electrocardiography. Patients were ineligible if they had a hemoglobin concentration less than 11g/dl, Hct less than 33%,[17] history of hematological disease, seizures or uncontrolled hypertension (i.e. diastolic blood pressure ≥ 100 mm Hg), had blood loss (e.g.…”

Section: Methodsmentioning

confidence: 99%

“…ABO blood group, Rh D phenotype and presence of red cell antibodies was determined in all patients taking part in the predeposit programme on all first units collected. [17] An ELISA performed was used to detect antibodies to rHuEPO in serum. Hemoglobin and Hct values were checked before and after each donation and daily after the operation until discharged.…”

Section: Methodsmentioning

confidence: 99%

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Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy in tertiary care hospitals of Jammu

Sharma¹,

Sharma²,

Pukhta³

et al. 2013

Asian J Transfus Sci

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Introduction:To study whether the administration of recombinant human erythropoietin increases the amount of autologous blood that can be collected before orthopaedic surgery.Materials and Methods:We conducted a randomized controlled trial of recombinant human erythropoietin in 68 adults scheduled for elective orthopedic procedures. The patients received either erythropoietin 600 units/kg of body weight or placebo intravenously every 5th day prior to each phlebotomy for 21 days during which time up to 5 units of blood was collected. Patients were excluded from donation when their hematocrit values were less than 33%. All patients received iron sulphate 325mg orally 3 times daily. The mean number of units collected per patient was 4.33 ± 0.4 for erythropoietin group and 3.05± 0.71 for the placebo group.Results:The mean packed red cell volume donated by patients who received erythropoietin was 32% greater than that donated by patients who received placebo (196.3 vs. 169.4 ml, p<0.05). 68% in the placebo group and 9% of patients treated with erythropoietin were unable to donate ≥4 units. No adverse effects were attributed to erythropoietin. While participating in the study, complications developed in 2 patients one in each group necessitating their removal from the study.Conclusion:We conclude that recombinant human erythropoietin increases the ability of the patients about to undergo elective surgery to donate autologous blood units.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy in tertiary care hospitals of Jammu

Sharma¹,

Sharma²,

Pukhta³

et al. 2013

Asian J Transfus Sci

View full text Add to dashboard Cite

show abstract

“…Of the 191 WHO member states, only 43% test blood for HIV, hepatitis C, and hepatitis B viruses. Transfusion-transmitted HIV infection is thought to account for 80,000-160,000 infections annually, contributing 2-4% of all cases of HIV transmission (Bharucha, et al, 2002). Only 20% of the world's supply of safe blood is available to countries with 80% of the world's population.…”

Section: Hiv Antibody Tests Fail To Identify Hiv-infected Blood Donatmentioning

confidence: 99%