Risk of Abdominal Obesity Associated with Phthalate Exposure of Nurses

Kolena, Branislav; Hlisníková, Henrieta; Kečkéšová, Ľubica; Šidlovská, Miroslava; Trnovec, T.; Petrovičová, Ida

doi:10.3390/toxics10030143

Cited by 7 publications

(3 citation statements)

References 60 publications

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“…Among the main ones, monosodium glutamate [73], carboxymethylcellulose, and polysorbate-80 stand out [74]. Finally, chemical compounds present in plastic packaging may be associated with obesity, for example, phthalates [7,75,76] and bisphenol A [66,[75][76][77][78][79][80][81]. These mechanisms highlight the importance of encouraging individuals on hemodialysis to limit the consumption of UPF in order to improve the nutritional status of abdominal obesity.…”

Section: Discussionmentioning

confidence: 99%

Consumption of Ultra-Processed Foods Is Associated with Abdominal Obesity in Individuals on Hemodialysis

Gering,

Martins,

Marques

et al. 2024

Preprint

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Consumption of ultra-processed foods is associated with abdominal obesity, but this association has not yet been investigated in individuals on hemodialysis. This cross-sectional study, developed with 1014 individuals, aimed to analyze the prevalence of abdominal obesity and its association with the consumption of ultra-processed foods in individuals on hemodialysis. Consumption of ultra-processed foods was measured using a questionnaire, whose list of foods was based on the Surveillance System of Risk and Protective Factors for Chronic Non-Communicable Diseases through Telephone Enquiry. Waist circumference was used to determine the presence of abdominal obesity. The difference in proportions between the independent variables and the outcome was verified using Pearson's chi-square test. Hierarchical logistic regression was used to determine the association between the outcome and the independent variables. The prevalence of abdominal obesity was 77.22%. In the final model, higher consumption of ultra-processed foods, be male and an adult, have between 8 and 11 years of schooling and practice physical activity below the recommended level increased the chances of having abdominal obesity. The research provides a basis for the creation and improvement of public policies that promote improvements in these health determinants.

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Section: Discussionmentioning

confidence: 99%

Consumption of Ultra-Processed Foods Is Associated with Abdominal Obesity in Individuals on Hemodialysis

Gering,

Martins,

Marques

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Females provided first-morning urine samples (2 × 2 mL). The description of qualitative and quantitative analysis of phthalate metabolites is described elsewhere [27]. We used high-performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS) (Infinity 1260 and 6410 triplequad, Agilent, Santa Clara, CA, USA) to analyze the urinary concentration of phthalate metanbolites by previously published on-line methods by HPLC-MS/MS [28,29].…”

Section: Urinary Analyses Of Phthalatesmentioning

confidence: 99%

Endocrine effect of phthalate metabolites and a butterfly effect of prenatal exposure to androgens on qualitative aspects of female sexual response- an initial survey

Kolena,

Hlisníková,

Nagyová

et al. 2024

Int J Impot Res

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There is growing evidence that endocrine disruptive chemicals have deleterious effects on sexual and reproductive function. To examine subjective sexual functions in human females and their relationship to postnatal phthalate exposure and perinatal androgenization, a Sexuality Score (SS) was established from a first-stage survey questionnaire of subjective sexual function filled out by female university students (n = 68; average age 25.23 ± 5.17 years; rural 25.51 ± 6.74 vs. urban 25.85 ± 1.43 years). Seventeen phthalate metabolites in urine samples were analyzed by high‐performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS). Females were also assessed for the 2D:4D digit ratio as an index of perinatal androgenization. The mean age of menarche was 12.82 ± 1.35 years (rural 12.59 ± 1.39 vs. urban 13.18 ± 1.27; p = 0.01). The mean age at first sexual intercourse was 14.88 ± 6.89 years (rural 14.62 ± 7.20 vs. urban 15.24 ± 6.55), and as the age of first sexual intercourse increases, the SS score tends to increase as well, albeit moderately (r = 0.25, p = 0.037). Mono‐iso‐butyl phthalate, mono(2‐ethyl‐5‐carboxypentyl) phthalate, mono(hydroxy‐n‐butyl) phthalate, mono(2‐ethyl‐5‐oxohexyl) phthalate (p ≤ 0.05) and mono(2-carboxymethylhexyl) phthalate (p ≤ 0.01) were negatively associated with SS. A compounding butterfly effect of prenatal exposure to androgens was observed with disruptive effects of mono(2‐ethyl‐5‐oxohexyl) phthalate and mono(2‐ethyl‐5‐carboxypentyl) phthalate on sexual function. Exposure to phthalates in adult females may lead to disruption of subjective sexual function, especially concerning sexual desire and sexual satisfaction, and perinatal androgenization could augment these effects.

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“…Finally, the original paper 'Risk of Abdominal Obesity Associated with Phthalate Exposure of Nurses' by Kolena et al assesses potential phthalate exposure among nurses by high-performance liquid chromatography and tandem mass spectrometry and anthropometric measurements, along with questionnaires. As a result, associations between mono-benzyl phthalate (MBzP) and body mass index (BMI), hip circumference (HC), waist circumference (WC), waist to height ratio (WHtR), and fat mass index (FMI), visceral fat content, BMI risk and hip index risk (HIrisk) were observed, suggesting that occupational exposure to phthalates may induce abdominal obesity and result in obesity-related metabolic disorders [8].…”

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confidence: 99%