2018
DOI: 10.1016/j.leukres.2018.07.016
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Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

Abstract: There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.

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Cited by 52 publications
(36 citation statements)
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“…8a). Future studies will reveal whether mutations induced by melphalan shape the evolution of relapsed disease or development of secondary malignancies, such as acute myeloid leukemia 44 .…”
Section: Discussionmentioning
confidence: 99%
“…8a). Future studies will reveal whether mutations induced by melphalan shape the evolution of relapsed disease or development of secondary malignancies, such as acute myeloid leukemia 44 .…”
Section: Discussionmentioning
confidence: 99%
“…55 years, $3 prior chemotherapy regimens, and TBI or busulfanbased conditioning. 43 These data suggest that, although secondary MDS/AML must be considered, the risk may be lowest in young less heavily pretreated patients conditioned with BEAM. Upfront risks for allo-HCT are generally related to acute GVHD and infectious complications, both of which can have a lifelong impact on quality of life.…”
Section: Novel Approaches To Allo-hctmentioning
confidence: 89%
“…This is not only due to the immediate toxicities of HDM-ASCT, but also the long-term risks such as an approximate 10-fold increase in myelodysplastic syndrome (MDS) and acute myelogenous leukaemia (AML) when compared to non-HDM-ASCT-based therapies. 4 Acknowledging geographical disparities in access to novel drugs, it is also important to note that the available therapeutic regimens for first-line treatment in many countries do not consistently deliver deep and durable treatment responses to the degree achieved by IMiD-PI combinations, and so HDM-ASCT will continue to play an important role in this regard. 5 In the USA, however, both IMiD and PI in the first-line setting are widely available and adopted by treatment guidelines and the Centres for Medicare and Medicaid Services (CMS).…”
Section: The Impact Of Novel Drug Combinationsmentioning
confidence: 99%
“…These observations may provide clues as to the biological underpinnings of the aforementioned data indicating that patients with MM previously treated with HDM-ASCT have a 50-to 100-fold higher risk of developing MDS/AML compared to the general population. 4 Moreover, as novel agents continue to increase in number and improve outcome for patients, it is possible that a higher incidence of secondary leukaemia in those exposed to HDM will be analogous to the current situation in Hodgkin lymphoma (HL), where patient survival over the past half-century has improved dramatically. As cured HL patients are now living for decades after their diagnosis, an increase in the incidence of secondary malignancies, most notably breast cancer from radiation therapy, has come to light, with breast cancer risk increasing by up to eightfold over that of the general population and persisting for 25 years.…”
Section: Hdm-asct Is a Potentially Toxic Therapymentioning
confidence: 99%