Risk of Adverse Cardiovascular Outcomes in Differentiated Thyroid Cancer Survivors: A Systematic Review and Meta-Analysis

Qiang, Judy; Alwithenani, Raad; Uleryk, Elizabeth; Ezzat, Shereen; Lipscombe, Lorraine; Sawka, Anna M.

doi:10.1089/thy.2022.0209

Cited by 7 publications

(4 citation statements)

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“…Our results were not entirely consistent with previous studies. A observational study had shown that there was no significant increase in the risk of HF in TC patients compared to the general population [relative risk = 0.98, 95%CI(0.60–1.59)] ( 12 ). Despite this study revealed that the risk of HF in TC patients is lower.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, studies by Pajamaki et al and Toulis et al did not demonstrate a significant risk of CAD in patients with TC ( 35 , 36 ). Qiang et al found suggested that, following adjustments for cardiovascular risk factors, individuals with TC faced an elevated risk of AF; And however, there was no significant increase in the risk of ischemic heart disease, stroke, or HF ( 12 ). They pointed out significant heterogeneity in the study results, influenced by potential confounding factors in the original research.…”

Section: Discussionmentioning

confidence: 99%

“…Many observational studies have indicated that TC patients are at increased risk of heart failure (HF), atrial fibrillation (AF), coronary artery disease (CAD), venous thromboembolism (VTE), and stroke ( 11 – 15 ). However, a meta-analysis revealed that the risk of HF in TC patients is lower [RR = 0.98, 95% CI (0.60–1.59)]; furthermore, after adjusting for cardiovascular risk factors, TC patients did not have a significant increase in the risk of ischemic heart disease, stroke, or HF ( 12 ). Meanwhile, Another study failed to find a significant association between a high risk of CVDs or AF and patients with TC ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that 21.7% of TC patients' deaths are related to coronary artery diseases (CADs) (9,10). Many observational studies have indicated that TC patients are at increased risk of heart failure (HF), atrial fibrillation (AF), coronary artery disease (CAD), venous thromboembolism (VTE), and stroke (11)(12)(13)(14)(15). However, a meta-analysis revealed that the risk of HF in TC patients is lower [RR = 0.98, 95% CI (0.60-1.59)]; furthermore, after adjusting for cardiovascular risk factors, TC patients did not have a significant increase in the risk of ischemic heart disease, stroke, or HF (12).…”

Section: Introductionmentioning

confidence: 99%

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Thyroid cancer and cardiovascular diseases: a Mendelian randomization study

Gao,

Wang,

et al. 2024

Front. Cardiovasc. Med.

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BackgroundMultiple observational studies have shown associations between thyroid cancer (TC) and cardiovascular diseases (CVDs). However, the results were inconsistent, and the potential causal genetic relationship remains unclear.MethodsThe genetic instruments of TC and CVDs were derived from data obtained through genome-wide association studies (GWAS). We performed the two-sample Mendelian randomization(MR) methods to investigate the causality of TC on CVDs. Summary-level statistics for CVDs, including heart failure (HF), atrial fibrillation (AF), coronary artery disease (CAD), myocardial infarction (MI), ischemic stroke (IS) and venous thromboembolism (VTE). The primary method employed in this MR analysis was the Inverse Variance Weighted (IVW) approach, and four additional algorithms were used: MR-Egger, weighted median, simple mode, and weighted mode. Additionally, we assessed the reliability of the causal relationship through pleiotropy, heterogeneity and leave-one-out sensitivity analysis.ResultsIn this MR analysis, we only detected causality of genetically predicted TC on HF (IVW method, odds ratio (OR) = 1.00134, 95% confidence interval (CI): 1.00023–1.00244, p = 0.017). However, There were no causal associations of TC with CAD, MI, AF, IS, and VTE.ConclusionOur results confirmed the causal association between TC and HF. It is crucial to closely monitor the incidence of HF in TC patients and give comprehensive clinical intervention based on conventional treatment.

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Section: Discussionmentioning

confidence: 99%