Risk of Adverse Outcomes in Pregnant Women Exposed to Solvents

Hewitt, Jeanne Beauchamp; Tellier, Laurie

doi:10.1111/j.1552-6909.1998.tb02618.x

Cited by 18 publications

(19 citation statements)

References 13 publications

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“…However, the number of exposed was not large enough to detect a statistical difference in risk between the exposed and unexposed groups, and adjusting for the included risk factors did not change that finding. Nevertheless, the point estimate of the overall risk had a higher precision in the present study than that reported in previously published cohort studies [6,8,9]. …”

Section: Discussioncontrasting

confidence: 70%

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Congenital anomalies in newborns to women employed in jobs with frequent exposure to organic solvents - a register-based prospective study

Vaktskjold¹,

Talykova²,

Nieboer

2011

BMC Pregnancy Childbirth

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BackgroundThe foetal effects of occupational exposure to organic solvents in pregnancy are still unclear. Our aim was to study the risk of non-chromosomal congenital anomalies at birth in a well-defined population of singletons born to women employed as painters and spoolers in early pregnancy, compared to women in non-hazardous occupations.MethodThe study population for this prospective cohort study was singleton newborns delivered to working mothers in the industrial community of Mončegorsk in the period 1973-2005. Occupational information and characteristics of the women and their newborns was obtained from the local population-based birth register.ResultsThe 597 women employed as painters, painter-plasterers or spoolers had 712 singleton births, whereof 31 (4.4%) were perinatally diagnosed with 37 malformations. Among the 10 561 newborns in the group classified as non-exposed, 397 (3.9%) had one or more malformations. The overall prevalence in the exposed group was 520/10 000 births [95% confidence limits (CL): 476, 564], and 436/10 000 births (95% CL: 396, 476) in the unexposed. Adjusted for young maternal age, smoking during pregnancy, maternal congenital malformation and year of birth, the odds ratio (OR) was 1.24 (95% CL: 0.85, 1.82); for multiple anomalies it was 1.54 (95% CL: 0.66, 3.59).The largest organ-system specific difference in prevalence between the two groups was observed for malformations of the circulatory system: 112/10 000 (95% CL: 35, 190) in the exposed group, and 42/10 000 (95% CL: 29, 54) in the unexposed, with an adjusted OR of 2.03 (95% CL: 0.85, 4.84). The adjusted ORs for malformations of the genital organs and musculoskeletal system were 2.24 (95% CI: 0.95, 5.31) and 1.12 (95% CI: (0.62, 2.02), respectively.ConclusionThere appeared to be a higher risk of malformations of the circulatory system and genital organs at birth among newborns to women in occupations with organic solvent exposure during early pregnancy (predominantly employed as painters). However, the findings were not statistically conclusive. Considering that these two categories of malformations are not readily diagnosed perinatally, the difference in prevalence between the exposed and unexposed may have been underestimated.

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Section: Discussioncontrasting

confidence: 70%

“…Both overall associations [5-7] and their absence [8,10] have been reported. The finding of an overall association with non-chromosomal malformations, primarily reflecting the occurrence of oro-facial clefts and urinary, male genital [7] and musculoskeletal malformations [5], support our results (urinary malformations excluded).…”

Section: Discussionmentioning

confidence: 99%

Congenital anomalies in newborns to women employed in jobs with frequent exposure to organic solvents - a register-based prospective study

Vaktskjold¹,

Talykova²,

Nieboer

2011

BMC Pregnancy Childbirth

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“…Benzene and xylene have been associated with arterial hypertension (7), and solvent exposure with hypertension in pregnancy (10,33). According to the study by Xiao and Levin (31), exposure to solvents can cause neurotoxic and neuropsychiatric symptoms and sleep disturbance.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exposure to Mixed Organic Solvents on Blood Pressure in Non-Smoking Women Working in a Pharmaceutical Company

Mohammadi

Golabadi

Labbafinejad

et al. 2012

Archives of Industrial Hygiene and Toxicology

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Some studies suggest that exposure to industrial solvents can affect blood pressure. The objective of this study was to investigate the effect of a mixture of organic solvents on blood pressure in women working in a pharmaceutical company in Iran. Four hundred and thirty-three women were included in the study. Women working in packing units (group 1) were not exposed to the mixture of organic solvents, women in new laboratory units (group 2) were exposed to the mixture within the permitted range and women working in old laboratory units (group 3) were exposed to the mixture above the permitted limit. We compared systolic and diastolic blood pressures (SBP & DBP) and prevalence of hypertension and prehypertension among groups. The results revealed a signifi cant difference in SBP and pre-hypertension (p<0.001) and hypertension (p<0.05) prevalence between the exposed and the control group, but DBP did not differ signifi cantly. Logistic regression analysis showed a signifi cant association between hypertension and exposure to mixed solvents. Odds ratio for hypertension in the group 2 and group 3 (exposed) workers was 2.36 and 3, respectively, compared to controls. Our results suggest that exposure to a mixture of organic solvents may increase SBP and hypertension and pre-hypertension prevalence in drug manufacture workers. Therefore, more attention should be paid to workers that work in such settings by periodically measuring blood pressure and implementing accurate and comprehensive programs to reduce exposure to organic solvents.

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“…Low birthweight has been associated with maternal race, 33 " 36 smoking, 26 ' 27 solvent exposure, 11 ' 12 electromagnetic radiation exposure, 37 working in electronics assembly 38 or in the chemical industry, 39 strenuous work, 19 noise exposure, 40 and caffeine intake. 41 Preterm delivery or premature birth has been associated with maternal race, 42 marital status, 43 smoking, 26 ' 27 alcohol consumption, 44 noise exposure, ^ occupational physical activity, 5 ' 45 and number of maternal medical conditions, 43 including chorioamnion and genital tract infections.…”

mentioning

confidence: 99%

Occupational and Environmental Exposure Correlates of Adverse Live-Birth Outcomes Among 1032 US Navy Women

Hourani

Hilton

2000

Journal of Occupational and Environmental Medicine

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Risk of Adverse Outcomes in Pregnant Women Exposed to Solvents

Cited by 18 publications

References 13 publications

Congenital anomalies in newborns to women employed in jobs with frequent exposure to organic solvents - a register-based prospective study

Congenital anomalies in newborns to women employed in jobs with frequent exposure to organic solvents - a register-based prospective study

Effects of Exposure to Mixed Organic Solvents on Blood Pressure in Non-Smoking Women Working in a Pharmaceutical Company

Occupational and Environmental Exposure Correlates of Adverse Live-Birth Outcomes Among 1032 US Navy Women

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