Risk of Alloimmunization and Delayed Hemolytic Transfusion Reactions in Patients With Sickle Cell Disease

Red blood cell alloimmunization among sickle cell Kuwaiti Arab patients who received red blood cell transfusion

“…One of the major complications of transfusion is alloimmunization in the recipient to antigens present in the transfused blood. In this study, 43.3% of 233 SCD patients who received transfusion formed clinically significant levels of alloantibodies, a frequency slightly above that reported in the literature, which is between 4 and 40% 4,8,15,17‐21 …”

Delayed Hemolytic Transfusion Reaction in Sickle Cell Disease

“…Marked reticulocytopenia is not always a feature of DHTR,18, 23 although many patients have reticulocyte counts that are lower than their baseline values. As patients with SCD have a shortened RBC survival, suppression of erythropoiesis has a profound effect on hemoglobin concentration compared to patients with normal red cell lifespan.…”

Incompatible blood transfusion in children in Burkina Faso

“…Unfortunately, this typing could be insufficient when repeated transfusions are needed, which is the case for children in whom malaria and sickle cell anaemia are one of the main causes of acute anaemia [2]. If there is likely repeated transfusion, phenotyped A, B, O and the five Rhesus antigens D, C, E, c, e as well as for Kell compatible red cells typing are recommended to minimize alloimmunization [3,4].…”