Risk of anaphylaxis in patients receiving beta-blocker drugs

Toogood, J.H.

doi:10.1016/0091-6749(88)90212-6

Cited by 158 publications

(83 citation statements)

References 45 publications

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“…Lower-osmolarity, non-ionic agents appear to be safer (Katayama et al 1990). Risk of reaction in patients on beta-blockers is higher (Toogood 1988). During anesthesia, common causes of fatal anaphylaxis include muscle relaxants, which may have a synergistic response with opioids to make reactions more severe .…”

Section: Drug/diagnostic Agent/iatrogenic Anaphylaxismentioning

confidence: 99%

“…An estimated 40 -100 Americans die annually due to envenomation and subsequent anaphylaxis from stinging insects of the order hymenoptera (Neugut et al 2001). One quarter of the 20 patients that die from anaphylaxis in the UK annually die from insect venom reactions (Toogood 1988). The patients in the UK registry who died from venom reactions had a peak age of 45 -70, tended to be male, and were often atopic ).…”

Section: Stinging Insect Venom Anaphylaxismentioning

confidence: 99%

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Why Do People Die of Anaphylaxis?—A Clinical Review

Kumar

Teuber

Gershwin

2005

Journal of Immunology Research

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Anaphylaxis is a source of anxiety for patients and healthcare providers. It is a medical emergency that presents with a broad array of symptoms and signs, many of which can be deceptively similar to other diseases such as myocardial infarction, asthma, or panic attacks. In addition to these diagnostic challenges, anaphylaxis presents management difficulties due to rapid onset and progression, lack of appropriate self-treatment education and implementation by patients, severity of the allergic response, exacerbating medications or concurrent disease, and unpredictability. The most common causes of anaphylaxis are food allergies, stinging insects and immunotherapy (allergy shots) but idiopathic anaphylaxis, latex allergy and drug hypersensitive all contribute to the epidemiology. Reactions to IVP and other dyes are coined anaphylactoid reactions but have identical pathophysiology and treatment, once the mast cell has been degranulated. As many antigens can be the trigger for fatal anaphylaxis, it is useful to examine the features of each etiology individually, highlighting factors common to all fatal anaphylaxis and some specific to certain etiologies. Generally what distinguishes a fatal from non fatal reaction is often just the rapidity to apply correct therapy. Prevention is clearly the key and should identify high-risk patients in an attempt to minimize the likely of a severe reaction. Although fatal anaphylaxis is rare, it is likely underreported.

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Section: Drug/diagnostic Agent/iatrogenic Anaphylaxismentioning

confidence: 99%

Section: Stinging Insect Venom Anaphylaxismentioning

confidence: 99%

Why Do People Die of Anaphylaxis?—A Clinical Review

Kumar

Teuber

Gershwin

2005

Journal of Immunology Research

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“…The inhibition of beta-adrenergic signals on effector cells of anaphylaxis, such as mast cells and basophilic granulocytes, by beta-adrenoceptor antagonists leads to inhibition of the cyclic AMP system and consequently to a destabilization of these cells (53). In addition, beta-adrenoceptor antagonists inhibit important blood pressure regulating mechanisms, both facilitating the induction and severity of anaphylaxis.…”

Section: Other Drugs Relevant To Anaphylaxismentioning

confidence: 99%

About the role and underlying mechanisms of cofactors in anaphylaxis

Wölbing

Fischer

Köberle

et al. 2013

Allergy

178

163

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Anaphylaxis is the systemic and most severe presentation of type I allergy. A number of conditions were identified that modulate the onset of anaphylaxis such as co-or augmentation factors, which significantly lower the allergen dose necessary for triggering anaphylaxis. Next to physical exercise or alcohol consumption, co-administration of nonsteroidal anti-inflammatory drugs (NSAID) or concomitant infectious diseases are well-documented cofactors of anaphylaxis. Registries for anaphylaxis document a role for cofactors in about 30% of anaphylactic reactions. Some disease entities such as 'wheat-dependent exercise-induced anaphylaxis' (WDEIA) are explicitly characterized by elicitation of anaphylaxis only in the presence of at least one such cofactor. Using WDEIA as a model disease, studies demonstrated that exercise increases skin prick test reactivity to and bioavailability of the allergen. Additional data indicate that alcohol consumption and NSAID administration display similar effects. Modulation of the cellular activation threshold is another mechanism underlying cofactor-induced anaphylaxis, most likely also functional when infectious diseases orchestrate elicitation of anaphylaxis. Cofactors are increasingly accepted to play a fundamental role in eliciting anaphylaxis. Consequently, to improve patient management modalities, a better understanding of the underlying mechanisms is warranted. This review aims to update clinicians and clinical scientists on recent developments.

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“…Ces derniers avaient été dénoncés dans le cadre des chocs anaphylactiques survenant au cours d'anesthésies, sans exclure la possibilité qu'ils soient aussi impliqués dans l'aggravation d'anaphylaxies alimentaires [17][18][19]. Le rôle de l'aspirine en prises orales dans l'anaphylaxie alimentaire avait été établi par l'étude des effets de l'allergène isolé ou associé à la prise d'aspirine [20,21].…”

Section: Agents Pharmacologiques Potentialisateurs De L'anaphylaxieunclassified

“…Cela prive l'organisme d'une réponse physiologique protectrice liée à la production par la médullo-surrénale de catécholamines dès qu'il y a libération d'histamine. Le collapsus installé est également réfractaire à l'administration d'adrénaline [17][18][19]. L'action principale pourrait se situer au niveau de l'endothélium, porteur de récepteurs bêta : en effet, la bêta-stimulation au niveau de l'endothélium prévient l'hyperperméabilité associée à l'anaphylaxie expérimentale [23].…”

Section: Agents Pharmacologiques Potentialisateurs De L'anaphylaxieunclassified

Facteurs de risque d’anaphylaxie alimentaire sévère

Moneret-Vautrin¹

2010

Med Sci (Paris)

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Risk of anaphylaxis in patients receiving beta-blocker drugs

Cited by 158 publications

References 45 publications

Why Do People Die of Anaphylaxis?—A Clinical Review

Why Do People Die of Anaphylaxis?—A Clinical Review

About the role and underlying mechanisms of cofactors in anaphylaxis

Facteurs de risque d’anaphylaxie alimentaire sévère

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