Risk of arbovirus emergence via bridge vectors: case study of the sylvatic mosquito Aedes malayensis in the Nakai district, Laos

Miot, Elliott F.; Calvez, Elodie; Aubry, Fabien; Dabo, Stéphanie; Grandadam, Marc; Marcombe, Sébastien; Oke, Catherine; Logan, James G.; Brey, Paul T.; Lambrechts, Louis

doi:10.1038/s41598-020-64696-9

Cited by 9 publications

(10 citation statements)

References 32 publications

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“…These observations could emphasize a crucial role of the midgut infection barrier and the salivary gland infection and escape barriers to limit the transmission of this virus for both lineages, whereas no impact was observed for the midgut escape barrier [ 41 , 42 ]. For the infection rate, these results contrasted with previous data obtained for other arboviruses such as DENV-1 and yellow fever virus (YFV; experiments conducted in Institut Pasteur, Paris) in Lao PDR [ 43 , 44 ]. For these flaviviruses, infection rates of Ae.…”

Section: Discussioncontrasting

confidence: 99%

Low Transmission of Chikungunya Virus by Aedes aegypti from Vientiane Capital, Lao PDR

Calvez

Miot

Keosenhom³

et al. 2022

Pathogens

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In 2012–2013, chikungunya virus (CHIKV) was the cause of a major outbreak in the southern part of Lao People’s Democratic Republic (Lao PDR). Since then, only a few imported cases, with isolates belonging to different lineages, were recorded between 2014 and 2020 in Vientiane capital and few autochthonous cases of ECSA-IOL lineage were detected in the south of the country in 2020. The CHIKV epidemiological profile contrasts with the continuous and intensive circulation of dengue virus in the country, especially in Vientiane capital. The study’s aim was to investigate the ability of the local field-derived Aedes aegypti population from Vientiane capital to transmit the Asian and ECSA-IOL lineages of CHIKV. Our results revealed that, for both CHIKV lineages, infection rates were low and dissemination rates were high. The transmission rates and efficiencies evidenced a low vector competence for the CHIKV tested. Although this population of Ae. aegypti showed a relatively modest vector competence for these two CHIKV lineages, several other factors could influence arbovirus emergence such as the longevity and density of female mosquitoes. Due to the active circulation of CHIKV in Southeast Asia, investigations on these factors should be done to prevent the risk of CHIKV emergence and spread in Lao PDR and neighboring countries.

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Section: Discussioncontrasting

confidence: 99%

Low Transmission of Chikungunya Virus by Aedes aegypti from Vientiane Capital, Lao PDR

Calvez

Miot

Keosenhom³

et al. 2022

Pathogens

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“…In the Lao PDR, a vector competence study has previously demonstrated a high transmission rate of DENV-1 by Ae. aegypti (transmission efficiency > 50% at 14 days post-infection) [50]. All these data thus emphasize the risk of DENV-1 epidemic re-emergence in the Lao PDR, especially during and after the rainy season.…”

Section: Discussionmentioning

confidence: 73%

Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR

Calvez¹,

Bounmany²,

Balière

et al. 2021

Microorganisms

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Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People’s Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010–2011. Between 2012 and 2020, major outbreaks due successively to DENV-3, DENV-4 and recently DENV-2 have been recorded. However, DENV-1 still co-circulated in the country over this period. Here, we summarize epidemiological and molecular data of DENV-1 between 2016 and 2020 in the Lao PDR. Our data highlight the continuous circulation of DENV-1 in the country at levels ranging from 16% to 22% among serotyping tests. In addition, the phylogenetic analysis has revealed the circulation of DENV-1 genotype I at least since 2008 with a co-circulation of different clusters. Sequence data support independent DENV-1 introductions in the Lao PDR correlated with an active circulation of this serotype at the regional level in Southeast Asia. The maintenance of DENV-1 circulation over the last ten years supports a low level of immunity against this serotype within the Lao population. Thereby, the risk of a DENV-1 epidemic cannot be ruled out in the future, and this emphasizes the importance of maintaining an integrated surveillance approach to prevent major outbreaks.

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“…Vector competence of Ae. aegypti from Lao PDR was investigated for DENV-1 and showed that 50% of the females orally exposed to the virus could transmit DENV-1 [ 52 ]. These data indicate a high efficiency of transmission of this serotype by Ae.…”

Section: Discussionmentioning

confidence: 99%

Trends of the Dengue Serotype-4 Circulation with Epidemiological, Phylogenetic, and Entomological Insights in Lao PDR between 2015 and 2019

Calvez¹,

Pommelet²,

Somlor³

et al. 2020

Pathogens

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Dengue outbreaks have regularly been recorded in Lao People’s Democratic Republic (PDR) since the first detection of the disease in 1979. In 2012, an integrated arbovirus surveillance network was set up in Lao PDR and an entomological surveillance has been implemented since 2016 in Vientiane Capital. Here, we report a study combining epidemiological, phylogenetic, and entomological analyzes during the largest DENV-4 epidemic ever recorded in Lao PDR (2015–2019). Strikingly, from 2015 to 2019, we reported the DENV-4 emergence and spread at the country level after two large epidemics predominated by DENV-3 and DENV-1, respectively, in 2012–2013 and 2015. Our data revealed a significant difference in the median age of the patient infected by DENV-4 compared to the other serotypes. Phylogenetic analysis demonstrated the circulation of DENV-4 Genotype I at the country level since at least 2013. The entomological surveillance showed a predominance of Aedesaegypti compared to Aedesalbopictus and high abundance of these vectors in dry and rainy seasons between 2016 and 2019, in Vientiane Capital. Overall, these results emphasized the importance of an integrated approach to evaluate factors, which could impact the circulation and the epidemiological profile of dengue viruses, especially in endemic countries like Lao PDR.

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Risk of arbovirus emergence via bridge vectors: case study of the sylvatic mosquito Aedes malayensis in the Nakai district, Laos

Cited by 9 publications

References 32 publications

Low Transmission of Chikungunya Virus by Aedes aegypti from Vientiane Capital, Lao PDR

Low Transmission of Chikungunya Virus by Aedes aegypti from Vientiane Capital, Lao PDR

Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR

Trends of the Dengue Serotype-4 Circulation with Epidemiological, Phylogenetic, and Entomological Insights in Lao PDR between 2015 and 2019

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