Risk of asthma and autoimmune diseases and related conditions in patients hospitalized for obesity

Hemminki, Kari; Li, Xinjun; Sundquist, Jan; Sundquist, Kristina

doi:10.3109/07853890.2010.547515

Cited by 18 publications

(16 citation statements)

References 25 publications

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“…Using the population-based Swedish Hospital Discharge Register, Hemminki et al . 22 observed that among patients hospitalized with a primary diagnosis of obesity, the relative incidence of Crohn’s disease is highest when obesity is diagnosed before 30 years of age (standardized incidence rate (SIR) 1.92, 95% CI 1.17–2.96), and decreases with increasing age at obesity diagnosis (SIR for Crohn’s disease when obesity diagnosed between 40–49 years of age 1.04, 95% CI 0.37–2.28). Additionally, magnitude of weight gain after age 18 years has also been associated with increased risk of Crohn’s disease, but not ulcerative colitis.…”

Section: Epidemiologymentioning

confidence: 99%

Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes

Singh

Dulai

Zarrinpar

et al. 2016

Nat Rev Gastroenterol Hepatol

318

285

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Incidence of IBD is rising in parallel with overweight and obesity. Contrary to conventional belief, about 15–40% of patients with IBD are obese, which might contribute to the development of IBD. Findings from cross-sectional and retrospective cohort studies are conflicting on the effect of obesity on natural history and course of IBD. Most studies are limited by small sample size, low event rates, non-validated assessment of disease activity and lack robust longitudinal follow-up and have incomplete adjustment for confounding factors. The effect of obesity on the efficacy of IBD-related therapy remains to be studied, though data from other autoimmune diseases suggests that obesity results in suboptimal response to therapy, potentially by promoting rapid clearance of biologic agents leading to low trough concentrations. These data provide a rationale for using weight loss interventions as adjunctive therapy in patients with IBD who are obese. Obesity also makes colorectal surgery technically challenging and might increase the risk of perioperative complications. In this Review, we highlight the existing literature on the epidemiology of obesity in IBD, discuss its plausible role in disease pathogenesis and effect on disease course and treatment response, and identify high-priority areas of future research.

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Section: Epidemiologymentioning

confidence: 99%

Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes

Singh

Dulai

Zarrinpar

et al. 2016

Nat Rev Gastroenterol Hepatol

318

285

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“…Using the Swedish Hospital Discharge Register, Hemminge et al [42] defined a cohort of patients hospitalized for obesity since year 1964. The patients were followed for hospitalization for selected autoimmune disease through year 2007.…”

Section: Obesity As a Risk Factor For The Development Of Ibdmentioning

confidence: 99%

“…The possible reason for these conflicting results is fact that the previously mentioned studies included children or young women as opposed to the EPIC study, which included both men and women and a large percentage of older people. It was suggested that the effect of obesity on risk of CD might be age-dependent, with obesity in young age prompting a higher risk of developing CD in older age [37,41,42].…”

Section: Obesity As a Risk Factor For The Development Of Ibdmentioning

confidence: 99%

Role of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases

et al. 2019

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Inflammatory bowel diseases (IBDs) are a group of disorders which include ulcerative colitis and Crohn’s disease. Obesity is becoming increasingly more common among patients with inflammatory bowel disease and plays a role in the development and course of the disease. This is especially true in the case of Crohn’s disease. The recent results indicate a special role of visceral adipose tissue and particularly mesenteric adipose tissue, also known as “creeping fat”, in pathomechanism, leading to intestinal inflammation. The involvement of altered adipocyte function and the deregulated production of adipokines, such as leptin and adiponectin, has been suggested in pathogenesis of IBD. In this review, we discuss the epidemiology and pathophysiology of obesity in IBD, the influence of a Western diet on the course of Crohn’s disease and colitis in IBD patients and animal’s models, and the potential role of adipokines in these disorders. Since altered body composition, decrease of skeletal muscle mass, and development of pathologically changed mesenteric white adipose tissue are well-known features of IBD and especially of Crohn’s disease, we discuss the possible crosstalk between adipokines and myokines released from skeletal muscle during exercise with moderate or forced intensity. The emerging role of microbiota and the antioxidative and anti-inflammatory enzymes such as intestinal alkaline phosphatase is also discussed, in order to open new avenues for the therapy against intestinal perturbations associated with IBD.

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“…Moreover, these data are in line with the predominance of CD over UC in the reported IBD cases occurring after bariatric surgery. Hemminki et al observed, in a population‐based Swedish hospital discharge register, that among hospitalised patients with a primary diagnosis of obesity, the relative incidence of CD was highest when obesity was diagnosed before 30 years of age, and decreased with increasing age (40‐49 years of age) at obesity diagnosis. Also, Mendall et al observed that obesity at diagnosis of IBD was significantly more common in subjects with CD than in UC, concluding that obesity may play a role in the pathogenesis of CD.…”

Section: Development Of De Novo Ibd After Bariatric Surgerymentioning

confidence: 99%

Review article: the relationship between obesity, bariatric surgery, and inflammatory bowel disease

Cañete

Mañosa

Clos

et al. 2018

Aliment Pharmacol Ther

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Risk of asthma and autoimmune diseases and related conditions in patients hospitalized for obesity

Cited by 18 publications

References 25 publications

Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes

Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes

Role of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases

Review article: the relationship between obesity, bariatric surgery, and inflammatory bowel disease

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