An analysis of the stages in the development of scientific research on the use of evidence-based medicine in osteopathy is presented. A search was conducted for scientific publications in the entire Medline database of the US National Center for Biotechnology Information (NCBI), starting in 1984. The main directions aimed at improving the quality and reliability of scientific research in osteopathy are described. As a discussion, it is proposed to use an assessment method that allows you to record three types of body reactions to the treatment — immediate, fast and delayed.