Risk of breast cancer and adipose tissue concentrations of polychlorinated biphenyls and organochlorine pesticides: a hospital-based case-control study in Chinese women

Huang, Wenlong; He, Yuanfang; Xiao, Jiefeng; Huang, Yan-ting; Li, Anna; He, Meirong; Wu, Kusheng

doi:10.1007/s11356-019-06404-3

Cited by 51 publications

(17 citation statements)

References 57 publications

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“…In the initial PubMed searches 165 articles published between 2017 and 2021 were found. After exclusion at various phases as explained above, 63 articles 19,61,64‐124 were included in the final literature sample (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature. While much of the recent evidence suggests causal relationships between pesticide exposure and cancer, the strongest evidence exists for acute myeloid leukemia (AML) and colorectal cancer (CRC), diseases in which the observed associations were consistent across several studies, including high‐quality prospective studies and those using biomarkers for exposure assessment, with some observing dose‐response relationships. Though high‐quality studies have been published since the IARC monograph on organophosphate insecticides in 2017, there are still gaps in the literature on carcinogenic evidence in humans for a large number of pesticides. To further knowledge, we suggest leveraging new techniques and methods to increase sensitivity and precision of exposure assessment, incorporate multi‐omics data, and investigate more thoroughly exposure to chemical mixtures. There is also a strong need for better and larger population‐based cohort studies that include younger and nonoccupationally exposed individuals, particularly during developmental periods of susceptibility. Though the existing evidence has limitations, as always in science, there is sufficient evidence to implement policies and regulatory action that limit pesticide exposure in humans and, hence, further prevent a significant burden of cancers.

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Section: Resultsmentioning

confidence: 99%

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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“…Various kinds of health disorders such as cancer, diabetes problems, respiratory issues, neurological disorders, reproductive syndromes and oxidative stress are produced due to direct or indirect exposure and handling of pesticides or their toxic active ingredients in foodstuffs ( Carles et al, 2017 ; Grewal, 2017 ; Rani et al, 2021 ). Some studies have revealed that due to continuous risk assessment of highly toxic compounds, including pesticides such as lung cancer, breast cancer, leukemia and multiple myeloma have occurred in human beings ( Han et al, 2018 ; Ruiz et al, 2018 ; Huang et al, 2019 ; Jaacks et al, 2019 ). Meng et al (2016) carried out a study to investigate agrochemical exposure in indoor dust and blood samples.…”

Section: Fate Of Pesticides In the Environmentmentioning

confidence: 99%

Contribution of insect gut microbiota and their associated enzymes in insect physiology and biodegradation of pesticides

Jaffar

Ahmad

2022

Front. Microbiol.

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Synthetic pesticides are extensively and injudiciously applied to control agriculture and household pests worldwide. Due to their high use, their toxic residues have enormously increased in the agroecosystem in the past several years. They have caused many severe threats to non-target organisms, including humans. Therefore, the complete removal of toxic compounds is gaining wide attention to protect the ecosystem and the diversity of living organisms. Several methods, such as physical, chemical and biological, are applied to degrade compounds, but as compared to other methods, biological methods are considered more efficient, fast, eco-friendly and less expensive. In particular, employing microbial species and their purified enzymes makes the degradation of toxic pollutants more accessible and converts them into non-toxic products by several metabolic pathways. The digestive tract of insects is usually known as a superior organ that provides a nutrient-rich environment to hundreds of microbial species that perform a pivotal role in various physiological and ecological functions. There is a direct relationship between pesticides and insect pests: pesticides reduce the growth of insect species and alter the phyla located in the gut microbiome. In comparison, the insect gut microbiota tries to degrade toxic compounds by changing their toxicity, increasing the production and regulation of a diverse range of enzymes. These enzymes breakdown into their derivatives, and microbial species utilize them as a sole source of carbon, sulfur and energy. The resistance of pesticides (carbamates, pyrethroids, organophosphates, organochlorines, and neonicotinoids) in insect species is developed by metabolic mechanisms, regulation of enzymes and the expression of various microbial detoxifying genes in insect guts. This review summarizes the toxic effects of agrochemicals on humans, animals, birds and beneficial arthropods. It explores the preferential role of insect gut microbial species in the degradation process and the resistance mechanism of several pesticides in insect species. Additionally, various metabolic pathways have been systematically discussed to better understand the degradation of xenobiotics by insect gut microbial species.

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“…Generally, a lot of original publications by authors from various scientific and research centres as well as literature reviews indicate a relationship between the use of plant protection products and the increased risk of developmental disorders, cancer diseases, etc. (Tayour et al 2019;Huang et al 2019;Han et al 2019;Sabarwal et al 2018;Zeng et al 2017;Narayan et al 2017;Egbuna et al 2020). Many papers also concern the safety of performing chemical plant protection treatments, including operator safety (Matthews 2008;Feola and Binder 2010;Damalas and Abdollahzadeh 2016).…”

Section: Introductionmentioning

confidence: 99%

The use of pesticides in Polish agriculture after integrated pest management (IPM) implementation

Piwowar

2021

Environ Sci Pollut Res

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The aim of the conducted study was to characterize the attitudes and practices of Polish farmers in the area of performing chemical plant protection treatments. A particular attention was paid to identifying the relationship between the direction of changes in the volume of chemical plant protection product consumption and selected attributes of farms. The main time range of the analyses covered the period of 2013–2017. Statistical data and results of representative surveys carried out on a sample of 1101 farms in Poland were used in the research process. Due to the large number of variants of the analysed variables, a multiple correspondence analysis was used, which made it possible to determine the correlation between the examined features (direction of changes in pesticide use relative to the farm area, economic size of the farm and location of the farm). Statistical analysis showed the existence of strong relationships between the physical (1) and economic (2) size of farms and the direction of changes in pesticide consumption ((1) φ2 = 0.0907; (2) φ2 = 0.1141)). According to empirical studies, the reduction of pesticide consumption took place mainly on the smallest farms. The implementation of the integrated plant protection directive has not resulted in significant changes in the form of reduced pesticide use in large-scale field crops. This raises the need to modify the strategy and model of crop protection in large-scale field crops in Poland.

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Risk of breast cancer and adipose tissue concentrations of polychlorinated biphenyls and organochlorine pesticides: a hospital-based case-control study in Chinese women

Cited by 51 publications

References 57 publications

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Contribution of insect gut microbiota and their associated enzymes in insect physiology and biodegradation of pesticides

The use of pesticides in Polish agriculture after integrated pest management (IPM) implementation

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