Risk of Cardiovascular Disease After COVID‐19 Diagnosis Among Adults With and Without Diabetes

Koyama, Alain; Imperatore, Giuseppina; Rolka, Deborah B.; Lundeen, Elizabeth A.; Rutkowski, Rachel E; Jackson, Sandra; He, Siran; Kuklina, Elena V.; Park, Soyoun; Pavkov, Meda E.

doi:10.1161/jaha.123.029696

Cited by 18 publications

(8 citation statements)

References 23 publications

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“…A third of our respondents had CVD relatively young mean age of the people surveyed (~45 years). A significant COVID-19 history-associated increase in CVD morbidity occurred in 40 to 49-year-old group of respondents, which agrees with observations that incident CVD may be a longterm outcome of COVID-19 infection [2,3,[30][31][32][33]. Indeed, non-ischemic myocardial fibrosis, exceeding the prevalence in the normal adult population, was found in every third patient with clinical suspicion of cardiovascular post-acute sequelae of SARS-CoV-2 infection.…”

Section: Discussionsupporting

confidence: 86%

Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study

Anfinogenova,

Maksimova,

Shelkovnikova

et al. 2024

Preprint

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Background: Online survey-based observational cross-sectional study aimed at elucidating experience and attitudes of unstructured population regarding diagnostic imaging. Methods: Invitations to participate were distributed using mixed-mode design to deidentified residents aged 18 years and older. Main outcome measures included morbidity structure and incidence of diagnostic imaging administrations. Results: Respondents (n = 1069) aged 44.3 ± 14.4 years; 32.8% suffered from cardiovascular diseases (CVD); 9.5% had chronic respiratory pathology; 28.9% considered themselves healthy. Respondents with COVID-19 history (49.7%) reported higher rates of computed tomography (CT) (p &lt; .0001), magnetic resonance imaging (MRI) (p &lt; .001), and ultrasound (p &lt; .05). COVID-19 history in CVD respondents shifted imaging administrations towards CT and MRI (p &lt; .05). Every tenth respondent received MRI, CT, and ultrasound on paid basis; 29.0% could not pay for diagnostic procedures; 13.1% reported unavailable MRI. Professional status significantly affected the pattern of diagnostic modalities (p &lt; .05). MRI and CT availability differed between respondents in urban and rural areas (p &lt; .0001). History of technogenic events predisposed responders to overestimate diagnostic value of fluorography (p &lt; .05). Conclusions: Preparedness to future pandemics requires development of community-based outreach programs focusing on people's awareness regarding medical imaging safety and diagnostic value.

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Section: Discussionsupporting

confidence: 86%

Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study

Anfinogenova,

Maksimova,

Shelkovnikova

et al. 2024

Preprint

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“…Cardiovascular illnesses such as myocarditis, arrhythmia, cardiogenic shock, heart failure, and other thromboembolic events are caused by the effect of the infection on the cardiovascular system. In addition to hypertensive individ-uals, the vascular endothelium can activate monocytes, resulting in almost uncontrollable cytokine production that may have a connection to COVID-19 [80].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Epidemiological Factors and SNP rs3804100 of TLR2 for COVID-19 in a Cohort of Professionals Who Worked in the First Pandemic Wave in Belém-PA, Brazil

Silva,

Marinho

et al. 2023

Genes

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COVID-19 is an infectious disease caused by coronavirus 2 of the severe acute syndrome (SARS-CoV-2). Single nucleotide polymorphisms (SNPs) in genes, such as TLR2, responsible for an effective human immune response, can change the course of infection. The objective of this article was to verify associations between epidemiological factors and TLR2 SNP rs3804100 (Thymine [T] > Cytosine [C]) in professionals from Health Institutions (HI) who worked during the first pandemic wave and COVID-19. A case-control study was conducted with Belém-PA HI workers (Northern Brazil), divided into symptomatology groups (Asymptomatic-AS; n = 91; and Symptomatic-SI; n = 123); and severity groups classified by Chest Computerized Tomography data (symptomatic with pulmonary involvement—SCP; n = 35; symptomatic without pulmonary involvement—SSP; n = 8). Genotyping was performed by Sanger sequencing, and Statistical Analysis was conducted through the SPSS program. Bioinformatics servers predicted the biological functions of the TLR2 SNP. There were associations between the presence of comorbidities and poor prognosis of COVID-19 (especially between symptomatology and severity of COVID-19 and overweight and obesity) and between the sickness in family members and kinship (related to blood relatives). The homozygous recessive (C/C) genotype was not found, and the frequency of the mutant allele (C) was less than 10% in the cohort. No significant associations were found for this SNP in this cohort. The presence of SNP was indicated to be benign and causes a decrease in the stability of the TLR2 protein. These data can help the scientific community and medicine find new forms of COVID-19 containment.

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“…Consequently, maintaining ongoing surveillance for the manifestation of cardiovascular conditions beyond the initial 30-day timeframe subsequent to a COVID-19 diagnosis is of paramount importance [86,87]. This phenomenon presents a new avenue for investigating the potential effects of both ADM and MR-proADM in post-acute COVID-19 patients.…”

Section: Knowledge Gap In Mr-proadm Levels and Cardiovascular Risk In...mentioning

confidence: 99%

Mid-Regional Proadrenomedullin in COVID-19—May It Act as a Predictor of Prolonged Cardiovascular Complications?

Pietraszko,

Zorawski,

Bielecka

et al. 2023

IJMS

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The rising prevalence of cardiovascular disease (CVD) and the impact of the SARS-CoV-2 pandemic have both led to increased mortality rates, affecting public health and the global economy. Therefore, it is essential to find accessible, non-invasive prognostic markers capable of identifying patients at high risk. One encouraging avenue of exploration is the potential of mid-regional proadrenomedullin (MR-proADM) as a biomarker in various health conditions, especially in the context of CVD and COVID-19. MR-proADM presents the ability to predict mortality, heart failure, and adverse outcomes in CVD, offering promise for improved risk assessment and treatment strategies. On the other hand, an elevated MR-proADM level is associated with disease severity and cytokine storms in patients with COVID-19, making it a predictive indicator for intensive care unit admissions and mortality rates. Moreover, MR-proADM may have relevance in long COVID, aiding in the risk assessment, triage, and monitoring of individuals at increased risk of developing prolonged cardiac issues. Our review explores the potential of MR-proADM as a predictor of enduring cardiovascular complications following COVID-19 infection.

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Risk of Cardiovascular Disease After COVID‐19 Diagnosis Among Adults With and Without Diabetes

Cited by 18 publications

References 23 publications

Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study

Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study

Analysis of Epidemiological Factors and SNP rs3804100 of TLR2 for COVID-19 in a Cohort of Professionals Who Worked in the First Pandemic Wave in Belém-PA, Brazil

Mid-Regional Proadrenomedullin in COVID-19—May It Act as a Predictor of Prolonged Cardiovascular Complications?

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