Risk of Cerebral Venous Thrombosis in Obese Women

Zuurbier, Susanna M.; Arnold, Marcel; Middeldorp, Saskia; Broeg-Morvay, Anne; Silvis, Suzanne M.; Heldner, Mirjam Rachel; Meisterernst, Julia Anne; Nemeth, Banne; Meulendijks, Eva R.; Stam, Jan; Cannegieter, Suzanne C.; Coutinho, Jonathan M.

doi:10.1001/jamaneurol.2016.0001

Cited by 78 publications

(53 citation statements)

References 41 publications

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“…Oral contraceptive use is by far the most common risk factor, reported in more than 80% of women in various series and associated with a pooled estimate of approximately 6‐fold increased risk of CVST . A recent case–control study showed that overweight and obesity in women using oral contraceptives further increased the risk of CVST up to 30‐fold in a dose‐dependent manner . An increase in risk also occurs with the multiplicative interaction between oral contraceptive use and the presence of thrombophilia abnormalities .…”

Section: Risk Factorsmentioning

confidence: 99%

Cerebral venous sinus thrombosis

Capecchi

Abbattista

Martinelli

2018

Journal of Thrombosis and Haemostasis

173

174

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The cerebral venous system is an unusual site of thrombosis, with a particularly high incidence in young adults. This incidence has increased in past decades because of the improvement of neuroradiological techniques. Risk factors for cerebral venous sinus thrombosis overlap with those of other venous thromboembolism sites; however, some are specific for this particular anatomical district. Prognosis is favorable in most cases if diagnosis is made rapidly and treatment is promptly initiated, even if acute complications or chronic invalidity still occur in a quarter of patients. The mainstay of treatment is anticoagulation, which is necessary in order to block clot propagation and obtain recanalization. Intracranial bleeding does not contraindicate anticoagulation. Endovascular procedures are reserved for patients with a particularly severe presentation or rapidly declining neurological symptoms despite appropriate anticoagulation, although data from clinical trials are lacking. Specifically, this review addresses the epidemiology, clinical presentation and course, risk factors, and treatment of cerebral venous sinus thrombosis, with a special focus on the pediatric population.

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Section: Risk Factorsmentioning

confidence: 99%

Cerebral venous sinus thrombosis

Capecchi

Abbattista

Martinelli

2018

Journal of Thrombosis and Haemostasis

173

174

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“…In a study, it was proposed that obesity was a risk factor of CVT, apparently stronger when accompanied with OCP use (14). However, our study subjects had a normal mean BMI.…”

Section: Discussionmentioning

confidence: 55%

Cerebral Venous Thrombosis in Pregnancy

Ala¹,

Hojjatpanah²,

Vahdati³

et al. 2019

Istanbul Med J

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Amaç: Sık görülen bir hastalık olmasa da, serebral venöz tromboz (SVT) nispeten morbid olarak kabul edilmiştir. İran'da SVT hakkında çok az araştırma vardır, ancak hamilelik ve lohusalıkta daha olasıdır. Bu nedenle gebelikte insidans ve risk faktörlerini belirlemek için bu çalışmayı yaptık. Yöntemler: Yirmi sekiz olgu hastane arşivinden seçildi. Nisan 2015-Mart 2018 tarihleri arasında hastaneye başvuran ve SVT tanısı almış gebelerin dosyaları demografik ve gebelik bilgileri açısından incelendi. İstatistiksel yöntemler ve yazılım kullanıldı. Conclusion: The study reveals some risk factors for CVT, such as immobilization, chronic hypertension, preeclampsia and caesarean section.

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“…Data from one pooled analysis,171 one cohort study172 and eight case-control studies45,164,166,173–179 showed that obese COC users consistently had VTE risk five to eight times that of obese non-users and approximately 10 times that of non-obese non-users. A single study180 of 129 cerebral venous thrombosis (CVT) cases suggested that COC users with BMI ≥25 kg/m 2 were at higher risk for CVT compared with normal-weight non-users (BMI <25 kg/m 2 ), and that increasing BMI was associated with increasing CVT risk, but due to the small sample size, estimates of this association were imprecise.…”

Section: Suitability Of Contraceptive Methods For Women Who Are Ovementioning

confidence: 99%

FSRH Guideline (April 2019) Overweight, Obesity and Contraception

2019

BMJ Sex Reprod Health

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Risk of Cerebral Venous Thrombosis in Obese Women

Cited by 78 publications

References 41 publications

Cerebral venous sinus thrombosis

Cerebral venous sinus thrombosis

Cerebral Venous Thrombosis in Pregnancy

FSRH Guideline (April 2019) Overweight, Obesity and Contraception

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