Risk of Cerebrovascular Accidents and Ischemic Heart Disease in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Singh, Siddharth; Singh, Harkirat; Loftus, Edward V.; Pardi, Darrell S.

doi:10.1016/j.cgh.2013.08.023

Cited by 232 publications

(166 citation statements)

References 51 publications

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“…A meta-analysis of nine studies observed an increase of 18% in the risk of stroke and ischemic heart disease in patients with IBD. The increased risk of stroke and ischemic heart disease was more prominent in females when compared to males, probably because of the inherent differences and non-modifiable risk factors (33) .…”

Section: Nutritional Status and Body Composition Of Patients With Ulcmentioning

confidence: 98%

Body Composition in Patients With Crohn’s Disease and Ulcerative Colitis

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Marcon

Gaino

et al. 2017

Arq. Gastroenterol.

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-Background -The nutritional status of individuals with inflammatory bowel diseases is directly related to the severity of the disease and is associated with poor prognosis and the deterioration of immune competence. Objective -To assess the nutritional status and the body composition of outpatients with inflammatory bowel diseases. Methods -A cross-sectional study was conducted with clinical and nutritional assessment of patients with Crohn's disease and ulcerative colitis. Patients were classified according to the clinical activity through Crohn's Disease Activity Index and Mayo Score. Nutritional assessment consisted of anthropometric measurements of current weight, height, mid-arm circumference, triceps skinfold thickness and thickness of adductor policis muscle, with subsequent calculation of BMI, arm muscle circumference and the mid-arm muscle area (MAMA

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Section: Nutritional Status and Body Composition Of Patients With Ulcmentioning

confidence: 98%

Body Composition in Patients With Crohn’s Disease and Ulcerative Colitis

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Marcon

Gaino

et al. 2017

Arq. Gastroenterol.

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“…[1][2][3] Inflammatory bowel disease (IBD) is characterized by intestinal inflammation and periodical flares with increased disease activity, and along with other chronic inflammatory diseases, IBD has been linked to an increased risk of cardiovascular disease, including myocardial infarction, stroke, and atrial fibrillation. [4][5][6][7][8][9] Research has provided evidence that inflammatory activation plays a role in the development and progression of HF, and the prothrombotic state associated with inflammation has been suggested as a causal link between IBD and atherothrombosis. [10][11][12][13][14][15][16][17] In addition, intestinal inflammation in IBD, especially during flares, may contribute to the development of HF by translocation of bacterial lipopolysaccharides from the bowel to the circulatory system that elicit production of proinflammatory mediators and tissue injury including myocardial damage.…”

mentioning

confidence: 99%

Inflammatory Bowel Disease Is Associated With an Increased Risk of Hospitalization for Heart Failure

Kristensen

Ahlehoff

Lindhardsen

et al. 2014

Circ: Heart Failure

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Background-Inflammatory bowel disease (IBD) has been linked to adverse cardiovascular events, but a relation to heart failure (HF) is uncertain. We investigated the IBD-associated risk of HF in a nationwide setting. Methods and Results-A total of 5 436 647 Danish citizens, with no history of IBD or HF, were included on January 1, 1997, and followed up until first hospitalization for HF, death, or December 31, 2011. Of these subjects, 23 681 developed IBD for which disease activity was determined continuously throughout the study. The risk of hospitalization for HF was estimated with a Poisson regression model adjusting for comorbidity and cardiovascular pharmacotherapy as timedependent covariates. During a mean follow-up of 11.8 years in the reference population and 6.4 years in the IBD group, hospitalization for HF occurred in 553 subjects with IBD and 171 405 in the reference population. Patients with IBD had a 37% increased risk of hospitalization for HF (incidence rate ratio, 1.37; 95% confidence interval, 1.26-1.49) compared with the reference population. IBD activity-specific analyses showed markedly increased risk of HF hospitalization during flares (incidence rate ratio, 2.54; 95% confidence interval, 2.13-3.04) and persistent activity (incidence rate ratio, 2.73; 95% confidence interval, 2.25-3.33) but not in IBD remission (incidence rate ratio, 1.04; 95% confidence interval, 0.94-1.16). Conclusions-In a nationwide cohort, IBD was associated with an increased risk of hospitalization for HF, and this risk was strongly correlated to periods of active disease. The mechanisms underlying this finding warrant further studies.(Circ Heart Fail. 2014;7:717-722.)

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“…Similarly, the existence of an accelerated atherosclerosis in IBD patients, purely due to the chronic inflammation, remains controversial based on data of two meta-analysis (6,7). A more recent meta-analysis, including 16 studies, found that IBD patients had a significantly higher CIMT mean values (standardized mean difference: 0.534 mm; 95% CI: 0.230-0.838; P=0.001) as compared to controls (12).…”

Section: Discussionmentioning

confidence: 99%

“…However, data are still contentious, particularly for IBD patients. Indeed, a meta-analysis of 11 studies showed no role for chronic inflammation in increasing the CV risk in these patients (6), whilst another by including data of nine studies found an increased risk (7). Therefore, further studies are needed to clarify such a field.…”

Section: Introductionmentioning

confidence: 99%

Preclinical atherosclerosis in patients with inflammatory bowel diseases: a case-control study

Bruzzese

Palermo

Lorenzetti

et al. 2017

Annals of Translational Medicine

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Background: An independent role of chronic inflammation in the atherosclerotic process in patients with inflammatory bowel diseases (IBD) has been suggested, but data are still contentious. We assessed preclinical atherosclerosis in the IBD patients without traditional risk factors. Methods:In this case-control study we assessed the early atherosclerotic alterations by carotid artery intima-media thickness (CIMT) measurement in IBD patients and matched controls. The normal CIMT values were ≤0.9 mm; moderate thickness when >0.9 and ≤1.2 mm, and pre-clinical atherosclerosis when >1.2 mm. We selected a homogeneous group of IBD patients, all in ongoing biologic therapy, without any traditional risk factor for atherosclerosis as well as controls. Conclusions: This case-control study found that the atherosclerotic process is not more apparent in IBD patients without traditional risk factors.

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Risk of Cerebrovascular Accidents and Ischemic Heart Disease in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Cited by 232 publications

References 51 publications

Body Composition in Patients With Crohn’s Disease and Ulcerative Colitis

Body Composition in Patients With Crohn’s Disease and Ulcerative Colitis

Inflammatory Bowel Disease Is Associated With an Increased Risk of Hospitalization for Heart Failure

Preclinical atherosclerosis in patients with inflammatory bowel diseases: a case-control study

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