Risk of childhood germ cell tumors in association with parental smoking and drinking

Chen, Zhi; Robison, Leslie L.; Giller, Roger; Krailo, Mark; Davis, Mary M.; Gardner, Kathleen; Davies, Stella M.; Shu, Xiao‐Ou

doi:10.1002/cncr.20894

Cited by 42 publications

(22 citation statements)

References 33 publications

(43 reference statements)

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“…Paternal smoking status and postnatal environmental or chemical hazard exposure experienced, which may also be associated with some childhood tumors, also could not be measured [16,49,57,17,68]. Exposure to household pesticides and increased risk of Wilms tumor have yet to be firmly established [61,69]; however, a review of studies has described that some association exists between pesticides and childhood cancer [63].…”

Section: Discussionmentioning

confidence: 94%

Maternal smoking during pregnancy and childhood cancer in New South Wales: a record linkage investigation

Stavrou

Baker

Bishop

2009

Cancer Causes Control

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Following linkage between the NSW Central Cancer Registry (CCR) and the NSW Midwives Data Collection, an investigation of the association between maternal smoking during pregnancy and the risk of childhood cancer in their offspring was undertaken. Children born in NSW between 1994 and 2005, inclusive of 1,045,966 babies, were matched to 948 cancer cases in the CCR. After adjustment for maternal age, gestational age, baby's gender, birth weight, remoteness index, socioeconomic disadvantage and maternal health factors, no association (OR = 0.96, 95% CI 0.81-1.15, p = 0.68) was found with childhood cancer between mothers who smoked (81/100,000) and those who did not smoke during pregnancy (99/100,000). Maternal smoking was, however, significantly associated with retinoblastoma (OR = 2.20, 95% CI 1.19-4.09, p = 0.01). Association between maternal smoking and preterm birth and low birth weight was significant. Maternal smoking during pregnancy is significantly associated with retinoblastoma and adverse birth outcomes. These results should be highlighted to expectant mothers through antitobacco-smoking campaigns.

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Section: Discussionmentioning

confidence: 94%

Maternal smoking during pregnancy and childhood cancer in New South Wales: a record linkage investigation

Stavrou

Baker

Bishop

2009

Cancer Causes Control

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“…Previous studies have shown that prenatal and early life exposures play a role in germ cell tumor carcinogenesis (Chen et al, 2005; Moller, 1997). Type 1 germ cell tumors consist of teratomas and yolk sac tumors that are found in neonates and children <5 years of age and most often are located in the testes, ovaries, retroperitoneum, in the hypophyseal region of the brain, and in the head and neck regions.…”

Section: Discussionmentioning

confidence: 99%

Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California

Park

Ritz

Ling

et al. 2017

International Journal of Hygiene and Environmental Health

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Background The incidence of childhood cancers has been increasing, and environmental exposure to air toxics has been suggested as a possible risk factor. This study aims to explore ambient exposure to dichloromethane (methylene chloride). Methods We frequency matched by birth year approximately 20 cancer-free controls identified from birth records to all childhood cancers ages 0–5 in the California Cancer Registry diagnosed from 1988–2012; i.e. 13,636 cases and a total of 270,673 controls. Information on industrial releases of dichloromethane within 3km of birth addresses was retrieved from mandatory industry reports to the EPA’s Toxics Release Inventory (TRI). We derived exposure to dichloromethane within close vicinity of birth residences using several modeling techniques including unconditional logistic regression models with multiple buffer distances, inverse distance weighting, and quadratic decay models. Results We observed elevated risks for germ cell tumors [Odds Ratio (OR): 1.52, 95% Confidence Interval (CI) 1.11, 2.08], particularly teratomas (OR: 2.08, 95% CI 1.38–3.13), and possible increased risk for acute myeloid leukemias (AML) (OR: 1.29, 95% CI 0.93, 1.77). Risk estimates were similar in magnitude whether releases occurred in pregnancy or the child’s first year of life. Conclusion Our findings suggest that exposure to industrial dichloromethane releases may be a risk factor for childhood germ cell tumors, teratomas, and possibly AML.

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“…For most pediatric GCTs there are no strong epidemiological associations with environmental factors [ 7 ] and no strong genetic associations reported, although both mediasinal and intracranial GCTs are more frequent in patients with Klinefelter syndrome [ 8 ]. In contrast to adult testicular GCTs which frequently demonstrate isochromosome 12p, there are no characteristic cytogenetic abnormalities in childhood cases, although chromosome 1p deletions leading to loss of heterozygosity (LOH) are reported more frequently in childhood malignant GCTs [ 9 ] and array CGH approaches have demonstrated that whilst infant teratomas show no consistent abnormality, in older children changes similar to adult cases, such as chromosome 12p gains, may be identifi ed [ 10 ].…”

Section: Associations Of Paediatric Germ Cell Tumoursmentioning

confidence: 98%

Germ Cell and Gonadal Tumours

Sebire

McHugh

2014

Pediatric Malignancies: Pathology and Imaging

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Risk of childhood germ cell tumors in association with parental smoking and drinking

Abstract: BACKGROUND. The etiology of childhood germ cell tumors (GCT) is not well

Cited by 42 publications

References 33 publications

Maternal smoking during pregnancy and childhood cancer in New South Wales: a record linkage investigation

Maternal smoking during pregnancy and childhood cancer in New South Wales: a record linkage investigation

Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California

Germ Cell and Gonadal Tumours

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