Risk of childhood overweight or obesity associated with excessive weight gain during pregnancy: a meta-analysis

Tie, Hongtao; Yi-yin, Xia; Zeng, Yong-Sheng; Zhang, Yong; Dai, Chia‐Liang; Guo, Jeff J.; Zhao, Yong

doi:10.1007/s00404-013-3053-z

Cited by 105 publications

(84 citation statements)

References 30 publications

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“…The short-term risks include intrapartal hypoxia, brachial plexus injuries, low Apgar score, asphyxia and hypoglycemia [4]. The long-term risks include childhood obesity, overweight, diabetes, metabolic syndrome and cancer later in life [5][6][7][8]. Moreover, giving birth to macrosomic infants is associated with a higher risk of maternal complications including hemorrhage, infection, preeclampsia, perinatal mortality, prolonged labor, operative deliveries and perineal injuries [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Excessive weight gain during pregnancy and risk of macrosomia: a meta-analysis

Tian

et al. 2015

Arch Gynecol Obstet

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Section: Introductionmentioning

confidence: 99%

Excessive weight gain during pregnancy and risk of macrosomia: a meta-analysis

Tian

et al. 2015

Arch Gynecol Obstet

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“…The effect of exceeding the clinical guidelines only previously has been investigated until age 20. For example, two meta-analyses 14,26 and at least eight other studies investigated pregnancy weight gain according to the IOM guidelines and weight in postnatal life, at birth 27–31 , childhood 32 and in young adulthood until 20 years of age. 33 Six studies showed that exceeding gestational weight guidelines was associated with a near twofold risk in having an overweight child, either by stratifying or controlling for pre-pregnancy BMI.…”

Section: Commentmentioning

confidence: 99%

“…A recent meta-analysis of seven studies found that pregnancy weight gain outside the ranges recommended by IOM 1 led to a higher risk for childhood overweight/obesity between the ages of 2 and 20 [combined adjusted odds ratio (OR) of 1.43 (95 % confidence interval (CI) 1.24–1.65)]. 14 It is currently unknown, however, whether the association between excessive pregnancy weight gain and offspring's risk of being overweight extends to midlife. We hypothesized that exceeding guidelines is associated with daughters’ risk of overweight/obesity independently of shared environmental or behavioral factors between the mother and daughter that may persist into adulthood.…”

Section: Introductionmentioning

confidence: 99%

Maternal weight gain in excess of pregnancy guidelines is related to daughters being overweight 40 years later

Houghton

Ester

Lumey

et al. 2016

American Journal of Obstetrics and Gynecology

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Background Exceeding the Institute of Medicine's guidelines for pregnancy weight gain increases childhood and adolescent obesity. However, it is unknown if these effects extend to mid-life. Objective To determine if exceeding the Institute of Medicine's guidelines for pregnancy weight gain increases risk of obesity in daughters 40 years later. Study Design This cohort study is based on adult offspring in The Child Health and Development Studies and the Collaborative Perinatal Population pregnancy cohorts originally enrolled in the 1960s. In 2005-2008, 1,035 daughters in their 40s were recruited to the Early Determinants of Mammographic Density study. We classified maternal pregnancy weight gain as greater than vs. less than or equal to the 2009 clinical guidelines. We used logistic regression to compare the odds ratios of daughters being overweight/obese (body mass index ≥25) at a mean age of 44 between mothers who did not gain or gained more than pregnancy weight gain guidelines , accounting for maternal pre-pregnant body mass index, and daughter's body size at birth and childhood. We also examined potential family related confounding through a comparison of daughter siblings using generalized estimating equations, clustered on sibling units and adjusted for maternal age and race. Results Mothers who exceeded guidelines for weight gain in pregnancy were more likely to have daughters who were overweight/obese in their 40s (odds ratio [OR], 3.4; 95% confidence interval {CI}, 2.0–5.7). This magnitude of association translates to a relative risk (RR) increase of 50% (RR = 1.5; 95% CI, 1.3-1.6). The association was of the same magnitude when examining only the siblings whose mother exceeded guidelines in 1 pregnancy and did not exceed the guidelines in the other pregnancy. The association was stronger with increasing maternal prepregnancy BMI (P trend < .001). Compared to mothers with BMI <25 who did not exceed guidelines, the relative risks (RR) for having an overweight/obese adult daughter were 1.3 (95% CI, 1.1-1.7), 1.7 (95% CI, 1.4-2.1) and 1.8 (95% CI, 1.5-2.1), respectively, if mothers exceeded guidelines and their prepregnancy BMI was <25, overweight (BMI 25-<30), or obese (BMI >30). This pattern held irrespective of daughters’ weight status at birth, at age 4 years, or at age 20 years. Conclusion Our findings support that obesity prevention before pregnancy and strategies to maintain weight gain during pregnancy within the Institute of Medicine guidelines might reduce the risk of being overweight in midlife for the offspring.

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“…[19] A recent meta-analysis estimated that excessive weight gain during pregnancy (defined somewhat differently across the 12 included studies) was associated with a an odds ratio of 1.3 (95% CI 1.2, 1.5) for obesity in children ranging in age from 2 to 18 years. [20] …”

Section: Gestational Weight Gain (Gwg)mentioning

confidence: 99%

Interrupting Intergenerational Cycles of Maternal Obesity

Gillman¹

2016

Nestlé Nutrition Institute Workshop Series

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Factors operating in the preconception and prenatal periods, such as maternal obesity, excessive gestational weight gain, and gestational diabetes, predict a substantial fraction of childhood obesity as well as lifelong adverse health consequences in the mother. These periods may lend themselves to successful intervention to reduce such risk factors because parents may be especially willing to change behavior if it confers health advantages to their children. If effective interventions started before or during pregnancy can be maintained after birth, they have the potential to lower the risk of both maternal obesity in the next pregnancy and obesity in the growing child, thus helping to interrupt maternal and child inter-generational vicious cycles of obesity, diabetes, and related cardiometabolic health consequences. While this paradigm is appealing, challenges include determining the magnitude, causality, and modifiability of these risk factors, and quantifying any adverse consequences of intervention.

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Risk of childhood overweight or obesity associated with excessive weight gain during pregnancy: a meta-analysis

Abstract: This meta-analysis suggests that the risk of childhood overweight/obesity is significantly associated with excessive gestational weight gain.

Cited by 105 publications

References 30 publications

Excessive weight gain during pregnancy and risk of macrosomia: a meta-analysis

Excessive weight gain during pregnancy and risk of macrosomia: a meta-analysis

Maternal weight gain in excess of pregnancy guidelines is related to daughters being overweight 40 years later

Interrupting Intergenerational Cycles of Maternal Obesity

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