Risk of Chronic Myeloid and Acute Leukemia Mortality after Exposure to Ionizing Radiation among Workers at Four U.S. Nuclear Weapons Facilities and a Nuclear Naval Shipyard

Schubauer‐Berigan, Mary K.; Daniels, Robert D.; Fleming, Donald A.; Markey, Andrea M.; Couch, James R.; Ahrenholz, Steven H.; Burphy, Jenneh S.; Anderson, Jeri L.; Tseng, Chih‐Yu

doi:10.1667/rr0724.1

Cited by 47 publications

(40 citation statements)

References 26 publications

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“…Our ERR/Sv is also higher than the estimated ERR/Sv found in the combined US study31 and in a meta-analysis of the risk of non-CLL leukaemia after chronic occupational or environmental exposure to ionising radiation 32. Despite improvement in the precision of the estimates compared to the previous analyses,6 19 the statistical uncertainties associated with our ERR/Sv estimates remain large.…”

Section: Discussioncontrasting

confidence: 61%

Mortality associated with chronic external radiation exposure in the French combined cohort of nuclear workers

et al. 2013

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Section: Discussioncontrasting

confidence: 61%

Mortality associated with chronic external radiation exposure in the French combined cohort of nuclear workers

et al. 2013

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“…Study no. 5 examined leukaemia mortality among nuclear workers from four US weapons facilities and a naval shipyard 23. Study no.…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of leukaemia risk from protracted exposure to low-dose gamma radiation

Daniels

Schubauer‐Berigan

2010

Occup Environ Med

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ContextMore than 400 000 workers annually receive a measurable radiation dose and may be at increased risk of radiation-induced leukaemia. It is unclear whether leukaemia risk is elevated with protracted, low-dose exposure.ObjectiveWe conducted a meta-analysis examining the relationship between protracted low-dose ionising radiation exposure and leukaemia.Data sourcesReviews by the National Academies and United Nations provided a summary of informative studies published before 2005. PubMed and Embase databases were searched for additional occupational and environmental studies published between 2005 and 2009.Study selectionWe selected 23 studies that: (1) examined the association between protracted exposures to ionising radiation and leukaemia excluding chronic lymphocytic subtype; (2) were a cohort or nested case–control design without major bias; (3) reported quantitative estimates of exposure; and (4) conducted exposure–response analyses using relative or excess RR per unit exposure.MethodsStudies were further screened to reduce information overlap. Random effects models were developed to summarise between-study variance and obtain an aggregate estimate of the excess RR at 100 mGy. Publication bias was assessed by trim and fill and Rosenthal's file drawer methods.ResultsWe found an ERR at 100 mGy of 0.19 (95% CI 0.07 to 0.32) by modelling results from 10 studies and adjusting for publication bias. Between-study variance was not evident (p=0.99).ConclusionsProtracted exposure to low-dose gamma radiation is significantly associated with leukaemia. Our estimate agreed well with the leukaemia risk observed among exposed adults in the Life Span Study (LSS) of atomic bomb survivors, providing increased confidence in the current understanding of leukaemia risk from ionising radiation. However, unlike the estimates obtained from the LSS, our model provides a precise, quantitative summary of the direct estimates of excess risk from studies of protracted radiation exposures.

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“…The risk of cancer was higher, though not statistically significantly higher, in the exposed group (Schubauer-Berigan et al, 2007).…”

Section: Radiation and Carcinogenesismentioning

confidence: 64%

Low-dose environmental radiation, DNA damage, and cancer: The possible contribution of psychological factors

Cwikel

Gidron

Quastel

2010

Psychology, Health & Medicine

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Radiation causes DNA damage, increases risk of cancer, and is associated with psychological stress responses. This article proposes an evidence-based integrative model in which psychological factors could interact with radiation by either augmenting or moderating the adverse effects of radiation on DNA integrity and eventual tumorigenesis. Based on a review of the literature, we demonstrate the following: (1) the effects of low-dose radiation exposures on DNA integrity and on tumorigenesis; (2) the effects of low-dose radiation exposure on psychological distress; (3) the relationship between psychological factors and DNA damage; and (4) the possibility that psychological stress augments and that psychological resource variables moderate radiation-induced DNA damage and risk of cancer. The additional contribution of psychological processes to radiation-DNA damage-cancer relationships needs further study, and if verified, has clinical implications.

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Risk of Chronic Myeloid and Acute Leukemia Mortality after Exposure to Ionizing Radiation among Workers at Four U.S. Nuclear Weapons Facilities and a Nuclear Naval Shipyard

Cited by 47 publications

References 26 publications

Mortality associated with chronic external radiation exposure in the French combined cohort of nuclear workers

Mortality associated with chronic external radiation exposure in the French combined cohort of nuclear workers

A meta-analysis of leukaemia risk from protracted exposure to low-dose gamma radiation

Low-dose environmental radiation, DNA damage, and cancer: The possible contribution of psychological factors

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