Risk of Circulatory Diseases on the Example of Heart Rhythm Disorders in Patients With Serological Markers of Epstein – Barr Infection

Solomay, T. V.; Семененко, Т А; Филатов, Н Н; Khabazov, Robert I.; Dupik, Nikolay V.; Дундуа, Д. П.; Kolyshkina, Nadezhda A.; Konev, A.V.

doi:10.21668/health.risk/2021.3.15.eng

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Установлена достоверная сильная пря мая корреляционная зависимость между по казателями заболеваемости инфекционным мононуклеозом и болезнями системы кровообра щения в Российской Федерации в динамике по годам. Кроме того, пациенты, страдающие нару шениями ритма сердца, имеют достоверно более высокий коэффициент позитивности IgG к капсид ному антигену ВЭБ (IgG VCA), чем лица без данной патологии [30].…”

Section: оригинальные статьи Original Articlesunclassified

Scientific Substantiation of the Creation and Prospects for the Development of an Epidemiological Surveillance System for Infection Caused by the Epstein-Barr Virus

Solomay

Симонова

Semenenko

2022

Epidemiology and Vaccinal Prevention

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Relevance. At the present stage, the Russian Federation does not have a coherent system of supervision and control of infection caused by the Epstein-Barr virus (EBV), while there is an epidemiological problem with this pathology, requiring the development and adoption of a set of adequate management decisions. The goal is to scientifically substantiate the creation of an epidemiological surveillance system (ES) for EBV -infection in Russia. Materials and methods. Based on the results of previous studies, an assessment of the manifestations of the epidemic process of EBV infection and measures aimed at each of its links was carried out. Results. The structure and content of the system of epidemiological surveillance of EBV infection are presented. Conclusion. To implement and improve the effectiveness of EBV-infection control, it is necessary to adjust existing and develop new regulatory and methodological documents that allow introducing: a standard definition of the case of EBV-infection and new approaches to accounting and registration; studies of nasopharyngeal smear material for the presence of EBV genetic material as part of the monitoring of influenza and ARVI pathogens; algorithms for the examination of patients with diagnoses that do not exclude the presence of active EBV-infection, as well as organ, tissue and cell donors with the determination of a complex of nonspecific immunological markers (neopterin, melatonin, C-reactive protein, ALT); standard operating procedures for medical professionals for the identification and isolation of patients with active EBV-infection, clinical and laboratory diagnostics, registration and accounting, the use of personal protective equipment and nonspecific immunoprophylaxis. Also, improving the control of EBVinfection is impossible without continuing scientific research; professional training of medical workers on the clinic, diagnosis, epidemiology and prevention of EBV-infection; development of modern visual methods and means of informing the population about the clinic and prevention of EBV-infection.

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Section: оригинальные статьи Original Articlesunclassified

Scientific Substantiation of the Creation and Prospects for the Development of an Epidemiological Surveillance System for Infection Caused by the Epstein-Barr Virus

Solomay

Симонова

Semenenko

2022

Epidemiology and Vaccinal Prevention

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The role of active herpesvirus infection in the formation of atopic dermatitis and psoriasis

Solomay

Semenenko

Vedunova

et al. 2022

Sibirskij nauchnyj medicinskij zhurnal

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Результаты ранее проведенных исследований позволяют предположить участие вирусов герпеса в развитии атопического дерматита и псориаза, однако убедительные доказательства отсутствуют. Цель настоящей работы -оценить роль активной герпес-вирусной инфекции в обострении атопического дерматита и псориаза. Материал и методы. Проведен анализ заболеваемости инфекционным мононуклеозом, генитальным герпесом, цитомегаловирусной инфекцией, болезнями кожи и подкожной клетчатки, атопическим дерматитом, псориазом в России в 2000-2020 гг. На наличие иммуноглобулинов M и G к вирусам простого герпеса (ВПГ1,2), Эпштейна-Барр (ВЭБ), цитомегаловируса (ЦМВ), герпеса человека 6-го типа (ВГЧ6) обследовано 92 донора крови и 97 пациентов с болезнями кожи и подкожной клетчатки (44 с атопическим дерматитом и 53 с псориазом). Результаты и их обсуждение. Выявлена значимая сильная прямая корреляционная связь между заболеваемостью генитальным герпесом и болезнями кожи и подкожной клетчатки (p = 0,85), атопическим дерматитом (p = 0,85); инфекционным мононуклеозом и псориазом (p = 0,85). Частота выявления IgM к ВПГ1,2, суммарно IgG к ядерному (IgG EBNA) и IgM к капсидному антигену ВЭБ (IgM VCA) в группе пациентов значимо выше, чем у доноров (р < 0,05). У больных атопическим дерматитом достоверно чаще, чем у лиц с псориазом, выявлялись IgM к ВПГ1 и достоверно реже маркеры активной ВЭБ-инфекции (p < 0,05). Наличие IgM к ВПГ1 статистически значимо повышает частоту развития атопического дерматита (относительный риск (ОР) = 2,3, 95%-й доверительный интервал (95 % ДИ) 1,6-3,3)), IgM VCA и IgG EBNA -псориаза (ОР = 2,3 (95 % ДИ 1,5-3,3)). Заключение. Впервые показано, что активная ВПГ1,2-инфекция является триггерным фактором развития обострения атопического дерматита, ВЭБ-инфекция-псориаза.Ключевые слова: вирусы герпеса, активная герпес-вирусная инфекция, атопический дерматит, псориаз, болезни кожи и подкожной клетчатки.Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

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The Economic Burden of Epstein–Barr Virus Infection in the Russian Federation

Solomay,

Voronin,

Semenenko

et al. 2024

PH&LE

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Introduction: Epstein–Barr virus-related diseases are of great medical and social importance, which requires assessment of economic losses due to costs of medical care and sickness absenteeism. Objective: To propose a methodology for assessing economic damage and to use it for quantification of total damages caused by Epstein–Barr virus (EBV) infections in the Russian Federation in 2022. Materials and methods: The economic damage from EBV infections was determined using official statistics on cases of infectious mononucleosis (2022), upper respiratory tract infections, cardiac arrhythmias, atopic dermatitis, dorsopathy, chronic tonsillitis in the acute phase, cerebrovascular disease, psoriasis, and multisystem inflammatory syndrome associated with COVID-19. Results: Based on the methodology for assessing economic damages described in the article, we found that the total financial losses from EBV-associated diseases in the Russian Federation in 2022 amounted to 1,203.0 billion or 1.2 trillion rubles, which is significantly higher than similar values for all other registered infectious diseases with the exception of COVID-19. COVID-19-related multisystem inflammatory syndrome, upper respiratory tract infections, and cerebrovascular disease account for more than 90 % of all losses. The structure of total costs is dominated by indirect economic losses (1,096.75 billion rubles or 91.2 %) due to sickness absence from work. Conclusion: The findings allow us to outline directions of developing measures to reduce the economic damage from EBV-associated diseases.

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Risk of Circulatory Diseases on the Example of Heart Rhythm Disorders in Patients With Serological Markers of Epstein – Barr Infection

Cited by 3 publications

References 24 publications

Scientific Substantiation of the Creation and Prospects for the Development of an Epidemiological Surveillance System for Infection Caused by the Epstein-Barr Virus

Scientific Substantiation of the Creation and Prospects for the Development of an Epidemiological Surveillance System for Infection Caused by the Epstein-Barr Virus

The role of active herpesvirus infection in the formation of atopic dermatitis and psoriasis

The Economic Burden of Epstein–Barr Virus Infection in the Russian Federation

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