Risk of CKD in Australian Indigenous and Nonindigenous Children: A Population-Based Cohort Study

Haysom, Leigh; Williams, Rita; Hodson, Elisabeth M; Lopez‐Vargas, Pamela; Roy, L. P.; Lyle, David; Craig, Jonathan C.

doi:10.1053/j.ajkd.2008.08.004

Cited by 22 publications

(13 citation statements)

References 21 publications

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“…In NSW, at a mean age of 8.9 years, in Indigenous children, the rate of albuminuria was 7.3%, obesity 5.3% and systolic hypertension 7.2%. This was no higher than in non‐Indigenous children 62 . Transient haematuria was more common in Indigenous children, but persistent haematuria was not.…”

Section: Markers Of Early Renal Diseasementioning

confidence: 68%

“…This was no higher than in non-Indigenous children. 62 Transient haematuria was more common in Indigenous children, but persistent haematuria was not. The study suggests that the increased risk of CKD in Aboriginal adults is not yet reflected in early renal markers at this age.…”

Section: Markers Of Early Renal Diseasementioning

confidence: 99%

“…Urinary abnormalities (haematuria and proteinuria) are commonly used as early markers of incipient CKD. Both in a high‐risk population in the Northern Territory (NT) 61 and in the New South Wales (NSW) population, 62 rates of albuminuria were low in childhood, perhaps indicating that more sensitive markers are needed to detect those at risk.…”

Section: Markers Of Early Renal Diseasementioning

confidence: 99%

See 2 more Smart Citations

The burden of kidney disease in Indigenous children of Australia and New Zealand, epidemiology, antecedent factors and progression to chronic kidney disease

White

Wong

Sureshkumur

et al. 2010

J Paediatrics Child Health

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Section: Markers Of Early Renal Diseasementioning

confidence: 68%

Section: Markers Of Early Renal Diseasementioning

confidence: 99%

Section: Markers Of Early Renal Diseasementioning

confidence: 99%

See 1 more Smart Citation

The burden of kidney disease in Indigenous children of Australia and New Zealand, epidemiology, antecedent factors and progression to chronic kidney disease

White

Wong

Sureshkumur

et al. 2010

J Paediatrics Child Health

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“…The prevalence of pre-hypertension is also increasing through childhood, especially among adolescents, as a consequence of weight gain [61]. In a high risk population for ESRD, Aboriginal Australians, Haysom et al [62] showed that only 20% of prepubertal children found to have markers of early CKD had persistent abnormalities (diastolic and systolic hypertension, albuminuria and hematuria) 2 years later, while persistent obesity was frequent, suggesting that adolescence and young adulthood is a more critical time for preventive strategies. In a rural community in Canada, Salvadori et al [63] found a strong relationship between overweight and obesity with both hypertension and pre-hypertension.…”

Section: Obesity-related Renal Injury In Childhoodmentioning

confidence: 99%

Obesity-Related Renal Injury in Childhood

Sereno

Pelliccia²,

Chiarelli³

et al. 2010

Horm Res Paediatr

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A significant increase in the prevalence of end-stage renal disease (ESRD) has been reported over the last three decades, paralleling the increasing prevalence of obesity and insulin resistance, also in the pediatric population. Overweight, obesity and the metabolic syndrome, which frequently coexist, contribute substantially to cardiovascular disease and ESRD. A higher body mass index, the presence of type 2 diabetes, hypertension and, of particular importance, reduced insulin sensitivity (IS), have recently emerged as strong independent risk factors for chronic kidney disease and ESRD. Of particular concern, the long-term cardiovascular impact of obesity, although deferred to adult life, has its origins in childhood. Clustering of cardiovascular risk factors is seen in children and adolescents with the highest degree of reduced IS, suggesting that adult consequences of obesity on target organs, including the kidney, are more likely to develop in these young people. This review will discuss the association between obesity and the risk of kidney disease, focusing on the way in which obesity and its metabolic complications may lead to renal involvement and injury, with particular regard to childhood. It is beyond the scope of this article to examine kidney disease as a component of syndromes that result in obesity in childhood.

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“…The increased risk of CKD in Australian Aboriginal adults is not established in childhood. 50 An interesting finding was the prevalence of proteinuria of ≥100 mg/L of 62.9% in people without DM in the Australian Aboriginal community of Woorabinda. 51 This suggests the dogma that most indigenous renal disease is due to DM is not universally correct.…”

Section: Australia New Zealand and South Pacific Islandsmentioning

confidence: 99%

Ethnicity and Chronic Kidney Disease in Disadvantaged Populations – An International Perspective

Correa‐Rotter

García-García

Iñiguez

et al. 2015

Chronic Renal Disease

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Risk of CKD in Australian Indigenous and Nonindigenous Children: A Population-Based Cohort Study

Cited by 22 publications

References 21 publications

The burden of kidney disease in Indigenous children of Australia and New Zealand, epidemiology, antecedent factors and progression to chronic kidney disease

The burden of kidney disease in Indigenous children of Australia and New Zealand, epidemiology, antecedent factors and progression to chronic kidney disease

Obesity-Related Renal Injury in Childhood

Ethnicity and Chronic Kidney Disease in Disadvantaged Populations – An International Perspective

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