Risk of Colonic Neoplasia After Liver Transplantation for Primary Sclerosing Cholangitis

Hanouneh, Ibrahim A.; Macaron, Carole; López, Rocío; Zein, Nizar N.; Lashner, Bret A.

doi:10.1002/ibd.21692

Cited by 41 publications

(34 citation statements)

References 32 publications

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“…PSC is an indication for liver transplantation, and 60-80% of individuals with PSC also have inflammatory bowel disease, predominantly UC. It is established that patients with UC are at high risk of colorectal cancer (39,40), and findings from a single retrospective study suggest that transplantation may not alter this inherently high risk (41). In our study, an excess risk of colorectal cancer was confined to liver transplant recipients with a history of PSC and UC.…”

Section: Discussionmentioning

confidence: 50%

Comparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients

Grulich

Meagher

et al. 2013

American Journal of Transplantation

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Population-based evidence on the relative risk of de novo cancer in liver and cardiothoracic transplant recipients is limited. A cohort study was conducted in Australia using population-based liver (n = 1926) and cardiothoracic (n = 2718) registries (1984-2006). Standardized incidence ratios (SIRs) were computed by cancer type, transplanted organ and recipient age. Cox regression models were used to compare cancer incidence by transplanted organ. During a median 5-year follow-up, the risk of any cancer in liver and cardiothoracic recipients was significantly elevated compared to the general population (n = 499; SIR = 2.62, 95%CI 2.40-2.86). An excess risk was observed for 16 cancer types, predominantly cancers with a viral etiology. The pattern of risk by cancer type was broadly similar for heart, lung and liver recipients, except for Merkel cell carcinoma (cardiothoracic only). Seventeen cancers (10 non-Hodgkin lymphomas), were observed in 415 pediatric recipients (SIR = 23.8, 95%CI 13.8-38.0). The adjusted hazard ratio for any cancer in all recipients was higher in heart compared to liver (1.29, 95%CI 1.03-1.63) and lung compared to liver (1.65, 95%CI 1.26-2.16). Understanding the factors responsible for the higher cancer incidence in cardiothoracic compared to liver recipients has the potential to lead to targeted cancer prevention strategies in this high-risk population.

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Section: Discussionmentioning

confidence: 50%

Comparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients

Grulich

Meagher

et al. 2013

American Journal of Transplantation

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“…(1-B)22. Seasonal inactivated influenza vaccination should be given for listed patients older than 6 months and their family members, and to family members of infants less than 6 months old.…”

mentioning

confidence: 99%

Evaluation of the Pediatric Patient for Liver Transplantation

Squires

Romero

et al. 2014

J. pediatr. gastroenterol. nutr.

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PREAMBLEC urrent American Association for the Study of Liver Diseases (AASLD) liver transplant evaluation guidelines include both adult and pediatric patients (1). While pediatric liver transplants account for $7.8% of all liver transplants in the United States, sufficient differences between pediatric and adult patients seeking liver transplantation (LT) now require independent, yet complementary documents. This document will focus on pediatric issues at each level of the evaluation process. Disease categories suitable for referral to a pediatric LT program are similar to adults: acute liver failure (ALF), autoimmune, cholestasis, metabolic or genetic, oncologic, vascular, and infectious; however, specific etiologies and outcomes differ widely from adult patients, justifying independent pediatric guidelines. Data supporting our recommendations

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“…Initially early diagnosis was associated with increased risk [16,19], while other work has demonstrated the opposite effect, with those who are elderly at diagnosis at higher risk [62,63]. Male gender also increase the risk Primary sclerosing cholangitis confers a 4-fold increase in risk of CRC development in UC patients [17,[64][65][66], with the increased risk persisting following liver transplantation [67,68].…”

Section: Risk Factorsmentioning

confidence: 99%

Colorectal Adenocarcinoma and Inflammatory Bowel Disease: An Update and Review

Karmali¹

2015

Surgery Curr Res

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Risk of Colonic Neoplasia After Liver Transplantation for Primary Sclerosing Cholangitis

Abstract: IBD/PSC patients remain at an increased risk of colon neoplasia after LT.

Cited by 41 publications

References 32 publications

Comparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients

Comparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients

Evaluation of the Pediatric Patient for Liver Transplantation

Colorectal Adenocarcinoma and Inflammatory Bowel Disease: An Update and Review

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