Risk of comorbid cardiovascular disease in Korean long‐term cancer survivors

Abstract

Background Cardiovascular disease (CVD) is a common cause of death in cancer survivors. We evaluated the risk of comorbid CVD in long‐term cancer survivors according to specific cancer site. Methods Study subjects included 47,171 Koreans aged over 40 years who visited a health promotion centre between 2010 and 2012. Information on CVD and cancer was obtained from self‐report. Comorbid CVD was defined as stroke, myocardial infarction or angina pectoris. The risk of comorbid CVD in survivors was compared with that in non‐cancer subjects using multiple logistic regression analysis. Results Among cancer survivors (n = 3,753), 330 events of CVD were reported. Age‐ and sex‐adjusted analysis showed that odds ratio (OR) for comorbid CVD in survivors was 1.52 (95% confidence interval: 1.34–1.72) compared to non‐cancer subjects (n = 43,418). After adjusting for health‐related behaviour and medical history, only lung cancer survivors had 2.44 (1.01–5.89)‐fold higher OR for CVD. In stratified analysis, significantly higher OR for CVD was evident in lung cancer survivors with hypertension who did not perform regular physical exercise. Conclusions Adult cancer survivors may have an increased risk of comorbid CVD that might be mediated in part by known cardiovascular risk factors depending on the specific cancer site.

Efficacy and Safety of the Cudrania tricuspidata Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study

“…The limitations of this study are the relatively short duration, small sample size, and lack of dose-response data. The enrollment and evaluation of subjects using a self-reported questionnaire might have resulted in biased study findings [26]. Since the diagnostic criteria for FD were various and the treatment of FD is not clear as a single agent, the effect of CTE could not be compared with the existing treatment but was compared with placebo.…”

Associations of a previous diagnosis of cancer and/or cardiovascular disease with current physical activity levels in Korean adults

“…In South Korea, CAN is the most common cause of death (27.0%), whereas heart disease (10.6%) and cerebrovascular disease (7.2%) are the second and fourth leading causes of death, respectively (Statistics Korea, 2020). Furthermore, many CAN patients have an increased risk of CVD death [3][4][5][6] that even exceeds the risk of death from CAN [7].…”