Risk of connective tissue disease and related disorders among women with breast implants: a nation-wide retrospective cohort study in Sweden

Abstract

Objective: To examine the relation between connective tissue disease and related conditions and breast implants. Design: Retrospective cohort study of all women in the Swedish national inpatient registry who underwent breast augmentation surgery with artificial implants during 1964-93, compared with women who underwent breast reduction surgery during the same period. Setting: Sweden.

Very Preterm Birth, Birth Trauma, and the Risk of Anorexia Nervosa Among Girls

“…The diagnoses in the birth and inpatient registers are coded according to the International Classification of Diseases, Eighth Revision (ICD-8), through 1986, and according to the International Classification of Diseases,, from 1987 to the time of this report. The inpatient register provides nationwide coverage from 1986 onward, 17 but as no specific diagnostic code of anorexia nervosa was available before 1987 (ie, using ICD-8 codes), the study was restricted to include subjects with anorexia nervosa from 1987 through 1994.…”

“…More than 99% of all births in Sweden are included in the birth register. 16 The Swedish Inpatient Register provides data on hospital discharges and diagnoses as classified by the treating physician, 17 and computerized information was available through 1994. The diagnoses in the birth and inpatient registers are coded according to the International Classification of Diseases, Eighth Revision (ICD-8), through 1986, and according to the International Classification of Diseases,, from 1987 to the time of this report.…”

A Prospective Study on Silicone Breast Implants and the Silicone-Related Symptom Complex

“…We did not find a relationship between increased SRSC complaints and ANA positivity or MRI changes in the silicone prostheses 1 year after SBI. While awaiting the results of the prospective study with a third measurement of SRSC-related complaints and ANA, we accept the conclusions from large retrospective cohort studies which could not find any risk of connective tissue disease in association with silicone prostheses [10,11,[28][29][30].…”

Breast implant design

“…Concerns regarding auto-immune reaction against silicone implants remain among a small group of the population, despite the numerous studies showing safety of the new implants (22,23,25,27,28,41). Several clinical studies have shown no difference in the incidence of autoimmune diseases in mastectomy patients receiving silicone gel implants compared to patients who had reconstruction with autogenous tissue (45)(46)(47)(48)(49)(50)(51). Even meta-analysis research combining data from over 87,000 women has revealed no association between silicone breast implants and connective tissue diseases (52,53).…”