Risk of death in Klebsiella pneumoniae bloodstream infections is associated with specific phylogenetic lineages

Fostervold, Aasmund; Raffelsberger, Niclas; Hetland, Marit A.K.; Bakksjø, Ragna; Bernhoff, Eva; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Afset, Jan E.; Berntsen, Christopher F.; Bævre-Jensen, Roar; Ebbesen, Marit H.; Gammelsrud, Karianne W.; Guleng, Anja D.; Handal, Nina; Jakovljev, Aleksandra; Johal, Simreen K.; Marvik, Åshild; Natvik, Ane; Sandnes, Rolf-Arne; Tofteland, Ståle; Bjørnholt, Jørgen V.; Löhr, Iren H.

doi:10.1016/j.jinf.2024.106155

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Preprint1

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Is it time to retire the term ‘bloodstream infection’? (Submitted as Letter to the Editor)

Musher,

Elisarraras

2024

Journal of Infection

View full text Add to dashboard Cite

Is it time to retire the term ‘bloodstream infection’? (Submitted as Letter to the Editor)

Musher,

Elisarraras

2024

Journal of Infection

View full text Add to dashboard Cite

‘Bloodstream infection’: A valuable concept we should keep in our toolbox

Danielsen,

Gu,

Fostervold

et al. 2024

Journal of Infection

View full text Add to dashboard Cite

A genome-wide One Health study ofKlebsiella pneumoniaein Norway reveals overlapping populations but few recent transmission events across reservoirs

Hetland,

Winkler,

Kaspersen

et al. 2024

Preprint

View full text Add to dashboard Cite

Members of theKlebsiella pneumoniaespecies complex (KpSC) are opportunistic pathogens that cause severe and difficult-to-treat infections. KpSC are common in non-human niches, but the clinical relevance of these populations is disputed. Utilising 3,255 whole-genome sequenced isolates from human, animal and marine sources collected during 2001-2020 in Norway, we showed the KpSC populations in different niches were distinct but overlapping. Notably, human infection isolates showed greatest connectivity with each other, followed by isolates from human carriage, pigs, and bivalves. Nearly 5% of human infection isolates had close relatives (≤22 substitutions) amongst animal and marine isolates, despite temporally and geographically distant sampling of these sources. Infection prevention measures are essential to limit transmission within human clinical settings and reduce disease burden. However, as colonisation often precedes infection, preventing transmission that leads to colonisation, e.g. transmission between animals and humans in the community, and in the food chain, could also be beneficial.

show abstract

Risk of death in Klebsiella pneumoniae bloodstream infections is associated with specific phylogenetic lineages

Cited by 3 publications

References 31 publications

Is it time to retire the term ‘bloodstream infection’? (Submitted as Letter to the Editor)

Is it time to retire the term ‘bloodstream infection’? (Submitted as Letter to the Editor)

‘Bloodstream infection’: A valuable concept we should keep in our toolbox

A genome-wide One Health study ofKlebsiella pneumoniaein Norway reveals overlapping populations but few recent transmission events across reservoirs

Contact Info

Product

Resources

About