Risk of dementia in patients with atrial fibrillation: Short versus long follow‐up. A systematic review and meta‐analysis

Zuin, Marco; Roncon, Loris; Passaro, Angelina; Bosi, Cristina; Cervellati, Carlo; Zuliani, Giovanni

doi:10.1002/gps.5582

Cited by 29 publications

(14 citation statements)

References 54 publications

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“…Obesity: The subject was considered as obese if they had the BMI values ≥30 kg/m 2 as indicated by the current AHA/ACC/TOS criteria for obesity in adults (Lavie et al, 2014). Positive history for vascular disease (i.e., heart attack, atrial fibrillation, and stroke): These diagnoses were made if the subject exhibited a medical documentation certifying a specific diagnosis after admission (Zuin et al, 2021). Dyslipidemia: For the evaluation of the presence/absence of dyslipidemia; the values of the obtained lipid fractions were dichotomized using the cutoffs for the Metabolic Syndrome recommended by the NCEP-ATPIII (Welty, 2001).…”

Section: Secondary Outcomes (Vascular Disease and Risk Factor Assessment)mentioning

confidence: 99%

Burning Fog: Cognitive Impairment in Burning Mouth Syndrome

Canfora

Calabria

Cuocolo

et al. 2021

Front. Aging Neurosci.

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Background: Due to its common association with chronic pain experience, cognitive impairment (CI) has never been evaluated in patients with burning mouth syndrome (BMS). The purpose of this study is to assess the prevalence of CI in patients with BMS and to evaluate its relationship with potential predictors such as pain, mood disorders, blood biomarkers, and white matter changes (WMCs).Methods: A case-control study was conducted by enrolling 40 patients with BMS and an equal number of healthy controls matched for age, gender, and education. Neurocognitive assessment [Mini Mental State Examination (MMSE), Digit Cancellation Test (DCT), the Forward and Backward Digit Span task (FDS and BDS), Corsi Block-Tapping Test (CB-TT), Rey Auditory Verbal Learning Test (RAVLT), Copying Geometric Drawings (CGD), Frontal Assessment Battery (FAB), and Trail Making A and B (TMT-A and TMT-B)], psychological assessment [Hamilton Rating Scale for Depression and Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and 36-Item Short Form Health Survey (SF-36)], and pain assessment [Visual Analogic Scale (VAS), Total Pain Rating index (T-PRI), Brief Pain Inventory (BPI), and Pain DETECT Questionnaire (PD-Q)] were performed. In addition, blood biomarkers and MRI of the brain were recorded for the detection of Age-Related WMCs (ARWMCs). Descriptive statistics, the Mann-Whitney U-test, the Pearson Chi-Squared test and Spearman's correlation analysis were used.Results: Patients with BMS had impairments in most cognitive domains compared with controls (p < 0.001**) except in RAVLT and CGD. The HAM-D, HAM-A, PSQI, ESS, SF-36, VAS, T-PRI, BPI and PD-Q scores were statistically different between BMS patients and controls (p < 0.001**) the WMCs frequency and ARWMC scores in the right temporal (RT) and left temporal (LT) lobe were higher in patients with BMS (p = 0.023*).Conclusions: Meanwhile, BMS is associated with a higher decline in cognitive functions, particularly attention, working memory, and executive functions, but other functions such as praxis-constructive skills and verbal memory are preserved. The early identification of CI and associated factors may help clinicians to identify patients at risk of developing time-based neurodegenerative disorders, such as Alzheimer's disease (AD) and vascular dementia (VD), for planning the early, comprehensive, and multidisciplinary assessment and treatment.

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Section: Secondary Outcomes (Vascular Disease and Risk Factor Assessment)mentioning

confidence: 99%

Burning Fog: Cognitive Impairment in Burning Mouth Syndrome

Canfora

Calabria

Cuocolo

et al. 2021

Front. Aging Neurosci.

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“…Eight meta-analyses focused on AF (29)(30)(31)(32)(33)(34)(35)(36). This included five studies focused on prospective cohort designs (31)(32)(33)(34)(35), one on longitudinal cohort designs (36), and two focused on both longitudinal cohort and retrospective case-control study designs (29,30). Four studies also included one or two individual studies that utilised secondary data from randomised control trials (30)(31)(32)35).…”

Section: Atrial Fibrillationmentioning

confidence: 99%

Cardiovascular disease, associated risk factors, and risk of dementia: An umbrella review of meta-analyses

et al. 2023

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IntroductionCardiovascular diseases (CVDs) have been associated with an increased risk of dementia; yet the evidence is mixed. This review critically appraises and synthesises current evidence exploring associations between dementia risk and CVD and their risk factors, including coronary heart disease, heart failure, atrial fibrillation, hypertension, hyperlipidaemia, and arterial stiffness.MethodsMEDLINE, Embase, PsycINFO, and the Cochrane Database of Systematic Reviews were searched to identify systematic reviews with meta-analyses investigating the association between at least one of the CVDs of interest and dementia risk. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Systematic Reviews was used to assess methodological quality.ResultsTwenty-five meta-analyses published between 2007 and 2021 were included. Studies largely consisted of cohorts from North America and Europe. Findings were variable, with coronary heart disease, heart failure, and atrial fibrillation consistently associated with increased risk for all-cause dementia, but results were inconsistent for Alzheimer's disease. Hypertension was more frequently associated with dementia during mid-life compared to late life. Findings concerning cholesterol were complex, and while results were inconsistent for low-density lipoprotein cholesterol and total cholesterol, there appeared to be no associations between triglycerides and high-density lipoprotein cholesterol. All meta-analyses investigating hypercholesterolaemia showed significant increases in dementia risk. There was a paucity of research on the association between arterial stiffness and dementia risk.ConclusionTargeted CVD dementia prevention strategies could reduce dementia prevalence. Future research should determine the underpinning mechanisms linking heart and brain health to determine the most effective strategies for dementia risk reduction in CVD populations.

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“…High priority was given to the record of risk factors for dementia. A focus was set on instantly modifiable established risk factors: arterial hypertension [26], diabetes mellitus [27,28], hypoacusis [29], low cognitive style [30], sedentary life style [31] and atrial fibrillation [32]. A number of further potential risk factors were also recorded: deficit of vitamin B12 [33], obstructive sleep apnoea [34][35][36][37][38][39], heart failure [40,41], vascular white matter lesions [42][43][44] and peripheral artery disease/coronary heart disease [45,46].…”

Section: Measurementsmentioning

confidence: 99%

The neurocognitive disorder cohort RIFADE: Aims, methods, first results showing cognitive improvement in a subgroup

Baumann

Lipka

Jänner

et al. 2022

Eur Arch Psychiatry Clin Neurosci

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Background The NCD cohort study RIFADE (RIsk FActors of DEmentia) investigates the interaction of risk factors and neurocognitive disorders (NCDs) due to Alzheimer’s disease (NCD-AD) and NCD of vascular type (NCD-vascular). Retrospective recruitment referred to a period from 2007 to 2018 in a single centre. In addition to the baseline visit, follow-up visits took place at 3, 6, 12 months followed by yearly visits. Visit times varied in part depending on adherence. The study also comprises an EEG bank and a bank with cerebral MRI (c-MRI). Methods Inclusion criteria were broad in order to cover a wide range of patterns of NCD. At baseline, patients underwent a large panel of assessments, e.g. including clinical history, diagnostic evaluation for NCD according to DSM-IV and NINDS AIREN criteria, a cognitive test battery including the DemTect, the clock drawing test and the Instrumental-Activities-of-Daily-Living-scale of Lawton and Brodie, EEG and c-MRI. At each follow-up visit, cognitive tests were repeated, in most cases also EEGs and in some cases c-MRIs. Numerous risk factors (RF) including vascular RF, atrial fibrillation, heart failure, sleep apnoea and lifestyle factors such as sedentary lifestyle, low cognitive style and smoking were evaluated for presence and for correction status at each visit, and modulation of uncorrected RF was initiated. Results Overall, 126 subjects with a clinical diagnosis of NCD were included (52% female, mean age 71 ± 10.6 years (range 35e86)), number of follow-up visits per subject 2.9 ± 2.4, observation time per subject 3.4 ± 2.8 years). Of these, 55/28/17% presented with the clinical stages subjective cognitive decline (SCD)/mild cognitive impairment (MCI)/dementia (major NCD). Clinical diagnoses, retrospectively re-evaluated according to DSM-5, were 5/21/68/6% Alzheimer´s disease (NCD-AD)/vascular NCD (NCD-vascular) / mixed NCD (NCD-AD + NCD-vascular)/unspecified NCD. First longitudinal results revealed a mean DemTect score at baseline 12.6 ± 4.2 vs last visit 12.0 ± 4.8 (p = 0.08) and a clock drawing test score at baseline 1.9 ± 1.3 vs last visit 2.3 ± 1.5 (p < 0.0001). Of all subjects with MCI or major NCD (n = 57), 19 improved in the clinical stage from baseline to last visit (33.3%). Sixteen subjects progressed from SCD or MCI (n = 104) to major NCD (15.4%). Conclusion The German NCD cohort RIFADE comprises patients with all clinical stages of NCD. A considerable subgroup improved in clinical stage. Further analysis is needed to answer the question of whether modulation of multiple risk factors provides a favourable effect on cognitive outcome in NCD.

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Risk of dementia in patients with atrial fibrillation: Short versus long follow‐up. A systematic review and meta‐analysis

Cited by 29 publications

References 54 publications

Burning Fog: Cognitive Impairment in Burning Mouth Syndrome

Burning Fog: Cognitive Impairment in Burning Mouth Syndrome

Cardiovascular disease, associated risk factors, and risk of dementia: An umbrella review of meta-analyses

The neurocognitive disorder cohort RIFADE: Aims, methods, first results showing cognitive improvement in a subgroup

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