Risk of depression following uterine cancer: A nationwide population‐based study

Chen, Chao Yu; Lee, Chuan-Pin; Wang, Ting Yao; Cheng, Bi Hua; Huang, Yin; Chen, Pau‐Chung; Liang, Sophie Hsin Yi; Dewey, Michael; Chen, Vincent Chin Hung

doi:10.1002/pon.4360

Cited by 14 publications

(11 citation statements)

References 30 publications

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“…Both studies, as well as other studies of specific cancer types, suggest that younger cancer patients are at higher risk of depression than older patients. 11,[22][23][24] The risk of MDD was also somewhat higher in women than in men in our study, consistent with the Swedish study. 11 The risk of MDD was elevated across a range of cancer types, with the highest risk seen in patients with multiple cancer sites, pancreatic cancer, brain/central nervous system cancer, and oral cavity/ pharynx cancer.…”

Section: Discussionsupporting

confidence: 91%

“…This difference reflects the employer‐based health insurance database used in the present study. Both studies, as well as other studies of specific cancer types, suggest that younger cancer patients are at higher risk of depression than older patients 11,22‐24 . The risk of MDD was also somewhat higher in women than in men in our study, consistent with the Swedish study 11 …”

Section: Discussionsupporting

confidence: 91%

“…In addition, most patients with cancer at multiple sites had metastatic cancer, which is usually more advanced and associated with worse outcomes. Cancers with better prognoses (eg, thyroid cancer) generally had lower risks of MDD, although patients with breast cancer, which has a 5-year relative survival rate 25 and conditional 5-year relative survival rate 26 22 head and neck, 27 lung, 24 colorectal, 28,29 thyroid, 30 gastric, 31 cervical, 32 and breast cancer, 33 as well as Hodgkin lymphoma. 34 The size of our study allowed us to determine the risk of MDD for many more types of cancer than previously studied.…”

Section: Discussionmentioning

confidence: 99%

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Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

et al. 2020

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Objective: Patients with cancer are at high risk of depression. However, the risk of major depressive disorder (MDD) after cancer diagnosis has not been studied in a population setting in Japan. This cohort study used a Japanese medical claims database to examine time to MDD in cancer patients and the risk of MDD (hazard ratio; HR) compared with matched cancer-free controls. Methods: Primary endpoint was time to MDD (starting 6 months before cancer diagnosis) in adult (18-74 years) cancer patients; secondary endpoint was time to MDD (6 months before to 12 months after cancer diagnosis) in a matched cohort of cancer patients and cancer-free controls. Multivariate analyses were performed to determine HRs for all cancers and for each cancer site. Results: Of 35 008 cancer patients (mean age, 53.3 years), 2201 (6.3%) were diagnosed with MDD within 66 months. Matched cancer patients (n = 30 372) had an elevated risk of MDD compared with cancer-free controls (n = 303 720; HR [95% confidence interval] 2.96 [2.77-3.16]). MDD risk was highest in patients with multiple cancers, pancreatic cancer, and brain cancer. Compared with middle-aged patients, risk was higher in patients <40 years old and lower in patients ≥65 years old; risk tended to be higher in women than in men. Conclusions: Compared with cancer-free individuals, Japanese patients with cancer, mostly <65 years old, had an almost threefold higher risk of developing MDD within 12 months of cancer diagnosis. Physicians should watch for MDD in cancer patients and treat when necessary.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

et al. 2020

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“…Our findings are consistent with those of previous studies. 14–16 In addition, other risk factors have been found to be associated with mental disorders in hospitalized patients including old age, 4 cancer, 5 coronary heart disease, 6,7 and surgery. 7 If the leading doctor considers the risks above, he/she may diagnose psychiatric disorders more accurately and may even be able to implement some intervention measures.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the substantial morbidity of psychiatric disorders, many nonpsychiatric physicians do not recognize these disorders or simply prescribe benzodiazepines, and this situation has become very concerning. Previous studies have shown that sleep disorders, 1 old age, 4 cancer, 5 coronary heart disease, 6,7 and surgery 7 are risk factors of psychiatric disorders, and these factors can thus be used to help detect possible psychiatric conditions. However, there are few studies on the risk factors of psychiatric disorders in which the chief complaint is related to sleep.…”

Section: Introductionmentioning

confidence: 99%

Psychiatric diagnoses and their influencing factors in patients complaining of sleep problems: A study of a psychiatric consultation-liaison service

Chen

Liao

et al. 2018

Int J Psychiatry Med

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Objective This study aimed to identify misdiagnosed or undiagnosed psychiatric disorders and the factors associated with these disorders in patients with sleep problems who are referred to a consultation-liaison service. Method Records of all inpatients receiving a consultation from the Psychiatry Department between January and December 2016 were retrospectively reviewed. Psychiatric diagnoses were analyzed using descriptive statistics, and the factors associated with the risk of these disorders in patients with sleep problems were determined by multiple logistic regression analysis. Results Of the 331 referral patients whose referral reason was simply having trouble in sleeping, only 97 patients were diagnosed with primary sleep disorder after consultation. The recognition rate of psychiatric disorders in inpatients with sleep problems among nonpsychiatric physicians was 29.3%. Anxiety (107, 45.7%) was the most common psychiatric diagnosis in patients with sleep problems followed by organic mental disorder (83, 35.5%), depression (37, 15.8%), and other mental disorders (8, 3.4%). Multiple logistic regression analysis revealed that a course >1 month (OR = 3.656, 95% CI = 2.171-6.156, p = 0.000) and sleep-wake rhythm disturbances (OR = 25.008, 95% CI = 5.826-107.341, p = 0.000) were associated with increased risks of psychiatric disorders. Conclusions The study showed that recognition rate of psychiatric disorders in inpatients with sleep problems was very low. A course >1 month and sleep-wake rhythm disturbances were associated with increased risks of disorders and could be used as indicators by nonpsychiatric physicians to improve diagnoses.

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Risk of Alzheimer's Disease in Obstructive Sleep Apnea Patients With or Without Treatment: Real‐World Evidence

Tsai

Huang

et al. 2020

The Laryngoscope

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ObjectiveTo assess the risk of Alzheimer's disease (AD) in patients with obstructive sleep apnea (OSA) with or without treatment based on real‐world evidence.Study DesignRetrospective cohort study.MethodsPatients newly diagnosed with OSA during 1997–2012 were identified using the National Health Insurance Research Database of Taiwan. Patients without OSA were randomly selected and matched in a 1:4 ratio by age, sex, urbanization level, and income. All patients were followed up until death or the end of 2013. The primary outcome was AD occurrence.ResultsThis study included 3,978 OSA patients and 15,912 non‐OSA patients. OSA was independently and significantly associated with a higher incidence of AD in an adjusted Cox proportional hazard model (adjusted hazard ratio: 2.12; 95% confidence interval [CI], 1.27–3.56). The average period of AD detection from the time of OSA occurrence was 5.44 years (standard deviation: 2.96). Subgroup analyses revealed that the effect of OSA remained significant in patients aged ≥60 years, male subgroups, patients without CPAP or surgical treatment, and patients without pharmacological therapies. Patients with OSA who received treatment (continuous positive airway pressure or surgery) exhibited a significantly reduced risk of AD compared with those without treatment (incidence rate ratio 0.23, 95% CI, 0.06–0.98).ConclusionOSA is independently associated with an increased risk of AD. Treatment for OSA reduces the AD risk in OSA patients. AD irreversibility renders OSA as a potential modifiable target for slowing or preventing the process of AD development.Level of EvidenceIV Laryngoscope, 130:2292–2298, 2020

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Risk of depression following uterine cancer: A nationwide population‐based study

Abstract: An increased risk of depression among younger uterine cancer patients was observed. Our preliminary finding suggests a possible protective factor for developing depression after HRT usage.

Cited by 14 publications

References 30 publications

Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

Psychiatric diagnoses and their influencing factors in patients complaining of sleep problems: A study of a psychiatric consultation-liaison service

Risk of Alzheimer's Disease in Obstructive Sleep Apnea Patients With or Without Treatment: Real‐World Evidence

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