Risk of Depression in Patients With Psoriatic Disease: A Systematic Review and Meta-Analysis

Lukmanji, Aysha; Basmadjian, Robert B.; Vallerand, Isabelle A.; Patten, Scott B.; Tang, Karen

doi:10.1177/1203475420977477

Cited by 21 publications

(12 citation statements)

References 49 publications

(72 reference statements)

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“…Depression, in contrast, is a well-researched and generally accepted comorbidity of psoriasis which has been studied in several systematic reviews and meta-analyses [33,34]. As depression is characterized by the reduced capability to experience positive emotions [35], the finding of low PA in patients with psoriasis could be explained by the higher prevalence of depressive symptoms in this patient group, which raises the question whether exploring affective wellbeing independently of depression does in fact provide new insights on the mental burden of psoriasis.…”

Section: Subjective Well-being and Depression In Psoriasismentioning

confidence: 99%

Happiness and depression in psoriasis: a cross-sectional study in Germany

et al. 2021

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Purpose Prior research on the psychological consequences of skin diseases has focused on assessing mental comorbidities. The aim of this study was to investigate subjective well-being in a large sample of individuals affected by psoriasis, a chronic inflammatory skin disease, and to explore the associations with depression and disease-related parameters such as disease severity. Methods A cross-sectional online survey was conducted from March to June 2019. The link to the questionnaire was shared on websites and Facebook pages of psoriasis patient organizations and campaigns. Participants filled in validated scales measuring subjective well-being—operationalized as positive affect (PA), negative affect (NA) and satisfaction with life (SWL); and depression. Results The data of 722 participants were analyzed. Exploratory factor analysis supported the differentiation of PA, NA, SWL, and depression as four different constructs. The respondents reported lower levels of PA than healthy individuals and judged themselves to be less happy and were less satisfied with their lives than the general population (except age group 65 + years). 40.3% of respondents were screened positive for depression. More severe psoriasis was associated with lower affective well-being and a higher risk for depression. Conclusion The results of this study empirically supported the differentiation of subjective well-being and depression as different constructs in individuals with psoriasis, and underline the large mental burden of the disease which goes beyond a higher risk for depression. Measures of well-being should thus be incorporated in both research and clinical practice in patients with psoriasis in order to achieve a more comprehensive picture of the mental burden of this disease.

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Section: Subjective Well-being and Depression In Psoriasismentioning

confidence: 99%

Happiness and depression in psoriasis: a cross-sectional study in Germany

et al. 2021

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“…Psoriasis is a chronic, inflammatory, multiorgan disease affecting 2% of UK adults, and is characterized by demarcated, salmon‐coloured plaques and extracutaneous manifestations such as arthritis and diabetes 19,20 . Psoriasis has been associated with a substantially increased risk of depression or anxiety disorders 21,22 and neurodevelopmental conditions, notably autism spectrum disorder 23,24 . The correlates of rarer skin conditions such as the inherited ichthyoses, which are characterized by abnormal keratinization, 25 are comparatively less well‐defined, although there is recent evidence that across the ichthyoses, rates of psychological distress are raised while QoL is diminished 26,27 .…”

Section: Introductionmentioning

confidence: 99%

Mood symptoms, neurodevelopmental traits, and their contributory factors in X-linked ichthyosis, ichthyosis vulgaris and psoriasis

Wren

Humby

Thompson

et al. 2022

Clinical and Experimental Dermatology

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Background. High rates of adverse mood/neurodevelopmental traits are seen in multiple dermatological conditions, and can significantly affect patient quality of life. Understanding the sex-specific nature, magnitude, impact and basis of such traits in lesserstudied conditions like ichthyosis, is important for developing effective interventions. Aim. To quantify and compare relevant psychological traits in men with X-linked ichthyosis (XLI, n = 54) or in XLI carrier women (n = 83) and in patients with ichthyosis vulgaris (IV, men n = 23, women n = 59) or psoriasis (men n = 30, women n = 122), and to identify factors self-reported to contribute most towards depressive, anxious and irritable phenotypes. Methods. Participants recruited via relevant charities or social media completed an online survey of established questionnaires. Data were analysed by sex and skin condition, and compared with general population data. Results. Compared with the general population, there was a higher rate of lifetime prevalence of mood disorder diagnoses across all groups and of neurodevelopmental disorder diagnoses in the XLI groups. The groups exhibited similarly significant elevations in recent mood symptoms (Cohen d statistic 0.95-1.28, P < 0.001) and neurodevelopmental traits (d = 0.31-0.91, P < 0.05) compared with general population controls, and self-reported moderate effects on quality of life and stigmatization. There were strong positive associations between neurodevelopmental traits and recent mood symptoms (r > 0.47, P < 0.01), and between feelings of stigmatization and quality of life, particularly in men. Numerous factors were identified as contributing significantly to mood symptoms in a condition or sex-specific, or condition or sex-independent, manner. Conclusion. We found that individuals with XLI, IV or psoriasis show higher levels of mood disorder diagnoses and symptoms than matched general population controls, and that the prevalence and severity of these is similar across conditions. We also identified a number of factors potentially conferring either general or conditionspecific risk of adverse mood symptoms in the three skin conditions, which could be targeted clinically and/or through education programmes. In clinical practice, recognizing mood/neurodevelopmental problems in ichthyosis and psoriasis, and addressing the predisposing factors identified by this study should benefit the mental health of affected individuals.

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“…Treatment failure can lead to psoriasis exacerbation and aggravate disease severity, 14 which increases the risk for depression and anxiety. 7 , 8 , 9 , 10 , 11 , 12 In turn, the patient’s psychological health has been associated with treatment failure in many chronic physical conditions, 30 , 31 including psoriasis. 32 Additionally, sustained depressive symptoms were found to worsen psoriasis clinical outcomes 32 , 33 through decreased sensitivity and poor adherence to treatment.…”

Section: Introductionmentioning

confidence: 99%

“…3 , 4 , 5 , 6 Compared with the general population, patients with moderate-to-severe psoriasis are at increased risk for depression and anxiety. 7 , 8 , 9 , 10 , 11 , 12 The economic burden of psoriasis is significant. The total annual cost was estimated at US$112 billion in the United States in 2013, of which, 56.4% were for direct health care costs.…”

Section: Introductionmentioning

confidence: 99%