“…With the emergence of a super-aging society, degenerative bone metabolic diseases such as osteoporosis and osteoproliferative diseases, including ossification of the posterior longitudinal ligament (OPLL) and diffuse idiopathic skeletal hyperostosis (DISH), have increased in number and garnered more attention [ 1 - 3 ]. While factors such as genetics, aging, sex, endocrinology, metabolism, inflammation, and lifestyle have been implicated in these bone metabolism diseases [ 1 - 3 ], their underlying pathology remains elusive. Gaining insights into the complexities of these conditions is essential not only for relieving the burdens on patients, healthcare providers, and society but also for enabling early diagnosis and intervention.…”